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Rybp RING1 and YY1 binding protein [ Mus musculus (house mouse) ]

Gene ID: 56353, updated on 25-Apr-2024

Summary

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Official Symbol
Rybpprovided by MGI
Official Full Name
RING1 and YY1 binding proteinprovided by MGI
Primary source
MGI:MGI:1929059
See related
Ensembl:ENSMUSG00000072872 AllianceGenome:MGI:1929059
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DEDAF; YEAF1; 2410018J24Rik
Summary
Enables DNA binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Is expressed in several structures, including brain; early embryo; extraembryonic component; genitourinary system; and nose. Orthologous to human RYBP (RING1 and YY1 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 21.3), CNS E18 (RPKM 18.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 D3; 6 46.62 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (100205526..100264319, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (100228565..100287358, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53300 Neighboring gene predicted gene, 33554 Neighboring gene predicted gene, 38867 Neighboring gene STARR-seq mESC enhancer starr_16853 Neighboring gene RNA binding motif protein 17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16856 Neighboring gene STARR-positive B cell enhancer mm9_chr6:100307038-100307339 Neighboring gene STARR-seq mESC enhancer starr_16858 Neighboring gene STARR-seq mESC enhancer starr_16863 Neighboring gene predicted gene, 38868 Neighboring gene predicted gene, 23234

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RYBP is important for cardiac progenitor cell development and sarcomere formation. Henry S, et al. PLoS One, 2020. PMID 32673370, Free PMC Article
  2. Rybp orchestrates spermatogenesis via regulating meiosis and sperm motility in mice. Tian Q, et al. Cell Cycle, 2020 Jun. PMID 32324084, Free PMC Article
  3. Ring 1 and YY1 Binding Protein Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis. He Z, et al. Genes (Basel), 2020 Jan 11. PMID 31940753, Free PMC Article
  4. Lack of Rybp in Mouse Embryonic Stem Cells Impairs Cardiac Differentiation. Ujhelly O, et al. Stem Cells Dev, 2015 Sep 15. PMID 26110923
  5. A novel target of microRNA-29, Ring1 and YY1-binding protein (Rybp), negatively regulates skeletal myogenesis. Zhou L, et al. J Biol Chem, 2012 Jul 20. PMID 22661705, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells.
    Title: Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells.
  2. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.
    Title: USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.
  3. Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells.
    Title: Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells.
  4. RYBP regulates Pax6 during in vitro neural differentiation of mouse embryonic stem cells.
    Title: RYBP regulates Pax6 during in vitro neural differentiation of mouse embryonic stem cells.
  5. RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern.
    Title: RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern.
  6. Rybp orchestrates spermatogenesis via regulating meiosis and sperm motility in mice.
    Title: Rybp orchestrates spermatogenesis via regulating meiosis and sperm motility in mice.
  7. Ring 1 and YY1 Binding Protein Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis.
    Title: Ring 1 and YY1 Binding Protein Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis.
  8. RYBP is important for cardiac progenitor cell development and sarcomere formation.
    Title: RYBP is important for cardiac progenitor cell development and sarcomere formation.
  9. The results suggest that histone H1-dependent chromatin compaction plays a critical role in the stable propagation of H2AK119ub1 by RYBP/YAF2-PRC1 during cell division.
    Title: RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division.
  10. Study reveals a complex pattern of gene regulation by SCL, ETO2 and RYBP. Genome-wide analyses shows locus-specific binding of ETO2 and RYBP on SCL's 778 activated and repressed genes.
    Title: SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC62213

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RING1 and YY1-binding protein
Names
DED-associated factor
Ring1 interactor Rybp
death effector domain-associated factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019743.3 → NP_062717.2  RING1 and YY1-binding protein

    See identical proteins and their annotated locations for NP_062717.2

    Status: PROVISIONAL

    Source sequence(s)
    AC158655
    Consensus CDS
    CCDS39579.1
    UniProtKB/Swiss-Prot
    B2RRB6, Q8CCI5, Q9WVK2
    Related
    ENSMUSP00000098677.3, ENSMUST00000101118.4
    Conserved Domains (3) summary
    sd00029
    Location:25 → 44
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:22 → 45
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam17219
    Location:145 → 176
    YAF2_RYBP; Yaf2/RYBP C-terminal binding motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    100205526..100264319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CCI5.1 GenPept UniProtKB/Swiss-Prot:Q8CCI5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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