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Trip4 thyroid hormone receptor interactor 4 [ Mus musculus (house mouse) ]

Gene ID: 56404, updated on 30-Apr-2024

Summary

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Official Symbol
Trip4provided by MGI
Official Full Name
thyroid hormone receptor interactor 4provided by MGI
Primary source
MGI:MGI:1928469
See related
Ensembl:ENSMUSG00000032386 AllianceGenome:MGI:1928469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asc1; ASC-1; 4930558E03Rik
Summary
Predicted to enable enzyme binding activity; estrogen receptor binding activity; and transcription coactivator activity. Involved in regulation of myoblast differentiation. Acts upstream of or within toxin transport. Predicted to be located in cytoplasm; neuromuscular junction; and nuclear body. Predicted to be part of activating signal cointegrator 1 complex. Predicted to be active in nucleus. Predicted to colocalize with centrosome. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; retina nuclear layer; and skin. Orthologous to human TRIP4 (thyroid hormone receptor interactor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.1), testis adult (RPKM 4.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Trip4 in Genome Data Viewer
Location:
9 C; 9 35.55 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65736208..65816150, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65828926..65908875, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9768 Neighboring gene STARR-seq mESC enhancer starr_24469 Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene zinc finger protein 609 Neighboring gene STARR-seq mESC enhancer starr_24471 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 53535 Neighboring gene STARR-positive B cell enhancer ABC_E6756 Neighboring gene STARR-seq mESC enhancer starr_24473 Neighboring gene predicted gene, 23248 Neighboring gene PCNA clamp associated factor Neighboring gene casein kinase 1, gamma 1 Neighboring gene predicted gene, 22657 Neighboring gene STARR-positive B cell enhancer mm9_chr9:65852147-65852448 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The transcription coactivator ASC-1 is a regulator of skeletal myogenesis, and its deficiency causes a novel form of congenital muscle disease. Davignon L, et al. Hum Mol Genet, 2016 Apr 15. PMID 27008887
  2. Activating signal cointegrator 1 is highly expressed in murine testicular Leydig cells and enhances the ligand-dependent transactivation of androgen receptor. Lee YS, et al. Biol Reprod, 2002 Nov. PMID 12390891
  3. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. Knierim E, et al. Am J Hum Genet, 2016 Mar 3. PMID 26924529, Free PMC Article
  4. Novel transcription coactivator complex containing activating signal cointegrator 1. Jung DJ, et al. Mol Cell Biol, 2002 Jul. PMID 12077347, Free PMC Article
  5. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Slater LH, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716698, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. homozygous and compound-heterozygous nonsense and frameshift TRIP4 and ASCC1 mutations that cosegregated with the Prenatal Spinal Muscular Atrophy and Congenital Bone Fracture phenotype
    Title: Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures.
  2. ASC-1 exists as a steady-state complex associated with three polypeptides, P200, P100, and P50, in HeLa nuclei.
    Title: Novel transcription coactivator complex containing activating signal cointegrator 1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of activating signal cointegrator 1 complex ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
activating signal cointegrator 1
Names
TR-interacting protein 4
TRIP-4
thyroid receptor-interacting protein 4
transcription coactivator Asc1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170907.1 → NP_001164378.1  activating signal cointegrator 1 isoform 2

    See identical proteins and their annotated locations for NP_001164378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC151906, AK039024, AW121332, BB617447
    Consensus CDS
    CCDS52838.1
    UniProtKB/TrEMBL
    Q3UJV0
    Related
    ENSMUSP00000112866.2, ENSMUST00000122410.8
    Conserved Domains (2) summary
    cd06554
    Location:434 → 525
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:168 → 216
    zf-C2HC5; Putative zinc finger motif, C2HC5-type

  2. NM_001357872.1 → NP_001344801.1  activating signal cointegrator 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC151906
    Consensus CDS
    CCDS23298.1
    UniProtKB/Swiss-Prot
    E9QK64, Q8CAD5, Q9QXN3
    UniProtKB/TrEMBL
    Q3UJV0
    Related
    ENSMUSP00000113949.2, ENSMUST00000117083.2
    Conserved Domains (2) summary
    cd06554
    Location:434 → 547
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:168 → 216
    zf-C2HC5; Putative zinc finger motif, C2HC5-type

  3. NM_019797.4 → NP_062771.2  activating signal cointegrator 1 isoform 1

    See identical proteins and their annotated locations for NP_062771.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also referred to as the testis specific form) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC151906, AW121332
    Consensus CDS
    CCDS23298.1
    UniProtKB/Swiss-Prot
    E9QK64, Q8CAD5, Q9QXN3
    UniProtKB/TrEMBL
    Q3UJV0
    Related
    ENSMUSP00000112385.2, ENSMUST00000119245.8
    Conserved Domains (2) summary
    cd06554
    Location:434 → 547
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:168 → 216
    zf-C2HC5; Putative zinc finger motif, C2HC5-type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    65736208..65816150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155144.1 → XP_036011037.1  activating signal cointegrator 1 isoform X2

    UniProtKB/TrEMBL
    Q3UJV0
    Related
    ENSMUSP00000137304.2, ENSMUST00000179395.8
    Conserved Domains (2) summary
    cd06554
    Location:434 → 525
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:168 → 216
    zf-C2HC5; Putative zinc finger motif, C2HC5-type

  2. XM_006511298.5 → XP_006511361.1  activating signal cointegrator 1 isoform X1

    See identical proteins and their annotated locations for XP_006511361.1

    UniProtKB/Swiss-Prot
    E9QK64, Q8CAD5, Q9QXN3
    UniProtKB/TrEMBL
    Q3UJV0
    Conserved Domains (2) summary
    cd06554
    Location:434 → 547
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:168 → 216
    zf-C2HC5; Putative zinc finger motif, C2HC5-type

  3. XM_030244463.2 → XP_030100323.1  activating signal cointegrator 1 isoform X1

    UniProtKB/Swiss-Prot
    E9QK64, Q8CAD5, Q9QXN3
    UniProtKB/TrEMBL
    Q3UJV0
    Conserved Domains (2) summary
    cd06554
    Location:434 → 547
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:168 → 216
    zf-C2HC5; Putative zinc finger motif, C2HC5-type

  4. XM_036155143.1 → XP_036011036.1  activating signal cointegrator 1 isoform X2

    UniProtKB/TrEMBL
    Q3UJV0
    Conserved Domains (2) summary
    cd06554
    Location:434 → 525
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:168 → 216
    zf-C2HC5; Putative zinc finger motif, C2HC5-type

  5. XM_036155146.1 → XP_036011039.1  activating signal cointegrator 1 isoform X3

    UniProtKB/TrEMBL
    Q3UBZ2
    Conserved Domains (1) summary
    pfam06221
    Location:168 → 216
    zf-C2HC5; Putative zinc finger motif, C2HC5-type

RNA

  1. XR_004935492.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXN3.2 GenPept UniProtKB/Swiss-Prot:Q9QXN3

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