U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

grm4 glutamate receptor, metabotropic 4 [ Danio rerio (zebrafish) ]

Gene ID: 567181, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
grm4provided by ZNC
Official Full Name
glutamate receptor, metabotropic 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5781
See related
Ensembl:ENSDARG00000040156 AllianceGenome:ZFIN:ZDB-GENE-030131-5781
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi18a01; wu:fi18a01
Summary
Predicted to enable adenylate cyclase inhibiting G protein-coupled glutamate receptor activity. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; cranial ganglion; motor neurons; and retinal neural layer. Orthologous to human GRM4 (glutamate metabotropic receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 6
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (46980595..47386224, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (46980638..47386818, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin like and fibronectin type III domain containing 1, tandem duplicate 3 Neighboring gene immunoglobulin like and fibronectin type III domain containing 1, tandem duplicate 1 Neighboring gene si:ch211-286o17.1 Neighboring gene uncharacterized LOC108190499

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio). Haug MF, et al. J Comp Neurol, 2013 May 1. PMID 23047810
  2. Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system. Huang YY, et al. PLoS One, 2012. PMID 22523578, Free PMC Article
  3. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
metabotropic glutamate receptor 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302241.1 → NP_001289170.1  metabotropic glutamate receptor 4 precursor

    See identical proteins and their annotated locations for NP_001289170.1

    Status: PROVISIONAL

    Source sequence(s)
    KF234086
    UniProtKB/TrEMBL
    U3N863
    Related
    ENSDARP00000130323.2, ENSDART00000162435.2
    Conserved Domains (4) summary
    pfam00003
    Location:598 → 843
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:76 → 478
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:516 → 559
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:46 → 507
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    46980595..47386224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_690474.8 → XP_695566.4  metabotropic glutamate receptor 4 isoform X1

    UniProtKB/TrEMBL
    A0A8N7UTB5
    Conserved Domains (3) summary
    pfam07562
    Location:520 → 569
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15452
    Location:589 → 916
    7tmC_mGluR4; metabotropic glutamate receptor 4 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:50 → 511
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  2. XM_021476905.1 → XP_021332580.1  metabotropic glutamate receptor 4 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QFH1
    Conserved Domains (4) summary
    pfam07562
    Location:520 → 569
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd14964
    Location:590 → 614
    7tm_GPCRs; TM helix 1 [structural motif]
    cl10011
    Location:50 → 511
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl28897
    Location:589 → 901
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_021476904.1 → XP_021332579.1  metabotropic glutamate receptor 4 isoform X1

    UniProtKB/TrEMBL
    A0A8N7UTB5
    Conserved Domains (3) summary
    pfam07562
    Location:520 → 569
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15452
    Location:589 → 916
    7tmC_mGluR4; metabotropic glutamate receptor 4 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:50 → 511
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  4. XM_021476906.1 → XP_021332581.1  metabotropic glutamate receptor 4 isoform X3

    UniProtKB/TrEMBL
    A0A8M9QAF2
    Conserved Domains (3) summary
    pfam07562
    Location:309 → 358
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15452
    Location:378 → 705
    7tmC_mGluR4; metabotropic glutamate receptor 4 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1 → 300
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous