Miox myo-inositol oxygenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mioxprovided by MGI
Official Full Name: myo-inositol oxygenaseprovided by MGI
Primary source: MGI:MGI:1891725
See related: Ensembl:ENSMUSG00000022613 AllianceGenome:MGI:1891725
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RSOR; Aldrl6; 0610009I10Rik
Summary: Enables aldo-keto reductase (NADP) activity and oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in inositol catabolic process. Located in cytoplasm. Is expressed in cortical renal tubule; metanephros; primitive collecting duct; and renal medulla. Orthologous to human MIOX (myo-inositol oxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward kidney adult (RPKM 2473.5) See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 44.82 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (89218676..89221210)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (89334473..89337007)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes.
Title: Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes.
these findings indicate that ferroptosis, an integral process in the pathogenesis of cisplatin-induced AKI, is modulated by the expression profile of MIOX.
Title: Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule.
MIOX-induced oxidant stress and tunicamycin-induced endoplasmic reticulum stress are interlinked, and both of the events may feed into each other to amplify the tubulointerstitial injury.
Title: Myo-inositol oxygenase accentuates renal tubular injury initiated by endoplasmic reticulum stress.
these findings highlight the epigenetic regulation of MIOX in the pathogenesis of diabetic tubulopathy.
Title: High Glucose-Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase: Implication in the Pathobiology of Diabetic Tubulopathy.
Data suggest that Miox expression/activity is up-regulated in kidneys tubules during oxidative stress (as in obesity and diabetic nephropathy); up-regulation of Miox activity is related to phosphorylation of serine/threonine residues.
Title: Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES.
MIOX expression attenuated tubular damage and improved renal function.
Title: Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney disease.
KSP-positive cells acquired the characteristics of each segment of renal tubular cells through tubular formation when stimulated with Wnt4.
Title: Kidney specific protein-positive cells derived from embryonic stem cells reproduce tubular structures in vitro and differentiate into renal tubular cells.
RSOR/MIOX modulates various downstream pathways affected by high-glucose ambience, and conceivably it plays a role in the pathobiology of tubulointerstitium in diabetic nephropathy.
Title: Pathobiology of renal-specific oxidoreductase/myo-inositol oxygenase in diabetic nephropathy: its implications in tubulointerstitial fibrosis.
These results indicate that MIOX is found at lower levels in extra-renal tissues where diabetic complications, including nephropathy, neuropathy, retinopathy, and cataract, are frequently observed.
Title: Expression of myo-inositol oxygenase in tissues susceptible to diabetic complications.
RSOR activity is modulated by diverse mechanisms, and it is endowed with dual properties to channel glucose intermediaries, characteristic of hepatic aldehyde reductases, and to maintain osmoregulation, in diabetes.
Title: Modulation of renal-specific oxidoreductase/myo-inositol oxygenase by high-glucose ambience.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

RH127192 (e-PCR)
- UniSTS:209130

AW108536 (e-PCR)
- UniSTS:209132

AI314022 (e-PCR)
- UniSTS:160497

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables aldo-keto reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables ferric iron binding	ISO Inferred from Sequence Orthology more info
enables inositol oxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol oxygenase activity	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	TAS Traceable Author Statement more info	PubMed
enables oxidoreductase activity, acting on NAD(P)H	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in inositol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inositol oxygenase

Names: MI oxygenase; aldehyde reductase (aldose reductase)-like 6; aldehyde reductase 6, renal; aldehyde reductase-like 6; renal-specific oxido-reducatse; renal-specific oxidoreductase

NP_064361.2

EC 1.13.99.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.