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Ralgapa1 Ral GTPase activating protein, alpha subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 56784, updated on 12-May-2024

Summary

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Official Symbol
Ralgapa1provided by MGI
Official Full Name
Ral GTPase activating protein, alpha subunit 1provided by MGI
Primary source
MGI:MGI:1931050
See related
Ensembl:ENSMUSG00000021027 AllianceGenome:MGI:1931050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GRIPE; Garnl1; Tulip1; mKIAA0884; 2310003F20Rik; 4930400K19Rik
Summary
Predicted to enable GTPase activator activity and protein heterodimerization activity. Acts upstream of or within regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in several structures, including 1st branchial arch; brain; and trunk. Orthologous to human RALGAPA1 (Ral GTPase activating protein catalytic subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 10.1), whole brain E14.5 (RPKM 7.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ralgapa1 in Genome Data Viewer
Location:
12 C1; 12 24.06 cM
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55649673..55868522, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55602888..55821574, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32194 Neighboring gene aldolase 1 A, retrogene 2 Neighboring gene insulinoma-associated 2 Neighboring gene STARR-seq mESC enhancer starr_32196 Neighboring gene STARR-seq mESC enhancer starr_32197 Neighboring gene STARR-positive B cell enhancer ABC_E11776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56937027-56937210 Neighboring gene breast cancer metastasis-suppressor 1-like Neighboring gene STARR-seq mESC enhancer starr_32198 Neighboring gene predicted gene, 22296

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The RalGAPα1-RalA signal module protects cardiac function through regulating calcium homeostasis. Zhu S, et al. Nat Commun, 2022 Jul 25. PMID 35879328, Free PMC Article
  2. Targeting RalGAPα1 in skeletal muscle to simultaneously improve postprandial glucose and lipid control. Chen Q, et al. Sci Adv, 2019 Apr. PMID 30989113, Free PMC Article
  3. Cloning, genomic structure, and expression profiles of TULIP1 (GARNL1), a brain-expressed candidate gene for 14q13-linked neurological phenotypes, and its murine homologue. Schwarzbraun T, et al. Genomics, 2004 Sep. PMID 15498464
  4. Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain. Heng JI, et al. J Biol Chem, 2002 Nov 8. PMID 12200424
  5. Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice. Tateno M, et al. Cancer Res, 2001 Feb 1. PMID 11221845

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RalGAPalpha1-RalA signal module protects cardiac function through regulating calcium homeostasis.
    Title: The RalGAPα1-RalA signal module protects cardiac function through regulating calcium homeostasis.
  2. interacts with transcription factor E12 in developing forebrain
    Title: Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables GTPase activator activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_negative_effect negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ral GTPase-activating protein subunit alpha-1
Names
GAP-related interacting partner to E12
GTPase activating RANGAP domain-like 1
GTPase-activating RapGAP domain-like 1
p240
ral GTPase-activating protein alpha subunit 1
tuberin-like protein 1
tulip 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003719.3 → NP_001003719.1  ral GTPase-activating protein subunit alpha-1 isoform 3

    See identical proteins and their annotated locations for NP_001003719.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region and an internal exon in the 3' region which results in an alternate downstream termination codon, compared to variant 4. The resulting isoform (3) lacks an internal segment but has a longer and distinct C-terminus, compared to isoform 4.
    Source sequence(s)
    AC107633, AC158398, AC159624
    UniProtKB/TrEMBL
    B7ZNA3
    Conserved Domains (1) summary
    pfam02145
    Location:1825 → 2001
    Rap_GAP; Rap/ran-GAP

  2. NM_001112714.3 → NP_001106185.1  ral GTPase-activating protein subunit alpha-1 isoform 2

    See identical proteins and their annotated locations for NP_001106185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an in-frame exon in the 5' coding region and a 3 nt exon in the 3' UTR, compared to variant 4. The resulting isoform (2) lacks an internal segment, compared to isoform 4. Variants 1 and 2 encode the same isoform 2.
    Source sequence(s)
    AC107633, AC158398, AC159624
    Consensus CDS
    CCDS36452.1
    UniProtKB/Swiss-Prot
    Q6GYP6, Q6GYP7, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4
    UniProtKB/TrEMBL
    B7ZNA3
    Related
    ENSMUSP00000082503.6, ENSMUST00000085385.7
    Conserved Domains (1) summary
    pfam02145
    Location:1825 → 2001
    Rap_GAP; Rap/ran-GAP

  3. NM_001286263.2 → NP_001273192.1  ral GTPase-activating protein subunit alpha-1 isoform 4

    See identical proteins and their annotated locations for NP_001273192.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes isoform 4.
    Source sequence(s)
    AC107633, AC158398, AC159624
    Consensus CDS
    CCDS88339.1
    UniProtKB/TrEMBL
    A0A1W2P832, B7ZNA3
    Conserved Domains (1) summary
    pfam02145
    Location:1872 → 2048
    Rap_GAP; Rap/ran-GAP

  4. NM_001368814.2 → NP_001355743.1  ral GTPase-activating protein subunit alpha-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107633, AC158398, AC159624
    UniProtKB/TrEMBL
    A0A2I3BRX9
    Conserved Domains (1) summary
    pfam02145
    Location:2328 → 2504
    Rap_GAP; Rap/ran-GAP

  5. NM_019994.6 → NP_064378.4  ral GTPase-activating protein subunit alpha-1 isoform 2

    See identical proteins and their annotated locations for NP_064378.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 4. The resulting isoform (2) lacks an internal segment, compared to isoform 4. Variants 1 and 2 encode the same isoform 2.
    Source sequence(s)
    AC107633, AC158398, AC159624
    Consensus CDS
    CCDS36452.1
    UniProtKB/Swiss-Prot
    Q6GYP6, Q6GYP7, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4
    UniProtKB/TrEMBL
    B7ZNA3
    Conserved Domains (1) summary
    pfam02145
    Location:1825 → 2001
    Rap_GAP; Rap/ran-GAP

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    55649673..55868522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516109.4 → XP_006516172.3  ral GTPase-activating protein subunit alpha-1 isoform X3

    UniProtKB/TrEMBL
    A0A2I3BRX9
    Related
    ENSMUSP00000154749.2, ENSMUST00000226244.2
    Conserved Domains (1) summary
    pfam02145
    Location:2281 → 2457
    Rap_GAP; Rap/ran-GAP

  2. XM_036157540.1 → XP_036013433.1  ral GTPase-activating protein subunit alpha-1 isoform X4

    UniProtKB/TrEMBL
    A0A2I3BRX9
    Conserved Domains (1) summary
    pfam02145
    Location:2281 → 2457
    Rap_GAP; Rap/ran-GAP

  3. XM_006516104.4 → XP_006516167.1  ral GTPase-activating protein subunit alpha-1 isoform X5

    UniProtKB/TrEMBL
    B7ZNA3
    Conserved Domains (1) summary
    pfam02145
    Location:1872 → 2048
    Rap_GAP; Rap/ran-GAP

  4. XM_036157542.1 → XP_036013435.1  ral GTPase-activating protein subunit alpha-1 isoform X7

    UniProtKB/TrEMBL
    A0A1W2P832, B7ZNA3
    Related
    ENSMUSP00000151857.2, ENSMUST00000219432.2
    Conserved Domains (1) summary
    pfam02145
    Location:1872 → 2048
    Rap_GAP; Rap/ran-GAP

  5. XM_030246826.2 → XP_030102686.1  ral GTPase-activating protein subunit alpha-1 isoform X2

    UniProtKB/TrEMBL
    A0A2I3BRX9
    Conserved Domains (1) summary
    pfam02145
    Location:2328 → 2504
    Rap_GAP; Rap/ran-GAP

  6. XM_030246825.2 → XP_030102685.1  ral GTPase-activating protein subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A0A2I3BRX9
    Conserved Domains (1) summary
    pfam02145
    Location:2328 → 2504
    Rap_GAP; Rap/ran-GAP

  7. XM_036157544.1 → XP_036013437.1  ral GTPase-activating protein subunit alpha-1 isoform X10

    Conserved Domains (1) summary
    pfam02145
    Location:1102 → 1278
    Rap_GAP; Rap/ran-GAP

  8. XM_036157545.1 → XP_036013438.1  ral GTPase-activating protein subunit alpha-1 isoform X11

    Conserved Domains (1) summary
    pfam02145
    Location:1096 → 1272
    Rap_GAP; Rap/ran-GAP

  9. XM_006516107.4 → XP_006516170.1  ral GTPase-activating protein subunit alpha-1 isoform X8

    UniProtKB/TrEMBL
    A0A1W2P712, B7ZNA3
    Related
    ENSMUSP00000151498.2, ENSMUST00000220367.2
    Conserved Domains (1) summary
    pfam02145
    Location:1825 → 2001
    Rap_GAP; Rap/ran-GAP

  10. XM_036157541.1 → XP_036013434.1  ral GTPase-activating protein subunit alpha-1 isoform X6

    UniProtKB/TrEMBL
    B7ZNA3
    Conserved Domains (1) summary
    pfam02145
    Location:1872 → 2048
    Rap_GAP; Rap/ran-GAP

  11. XM_036157543.1 → XP_036013436.1  ral GTPase-activating protein subunit alpha-1 isoform X9

RNA

  1. XR_004937530.1 RNA Sequence

  2. XR_004937531.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GYP7.1 GenPept UniProtKB/Swiss-Prot:Q6GYP7

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