Gnasas1 GNAS antisense RNA 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gnasas1provided by MGI
Official Full Name: GNAS antisense RNA 1provided by MGI
Primary source: MGI:MGI:1861674
See related: Ensembl:ENSMUSG00000086537 AllianceGenome:MGI:1861674
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nespas; Nespos; Gnas-as
Summary: Acts upstream of or within several processes, including DNA methylation; genetic imprinting; and skin development. Is expressed in several structures, including brain; limb; and somite. Used to study pseudohypoparathyroidism. Human ortholog(s) of this gene implicated in pseudohypoparathyroidism type IB. Orthologous to human GNAS-AS1 (GNAS antisense RNA 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 5.0), testis adult (RPKM 3.2) and 11 other tissues See more
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Genomic context

Location:: 2 H4; 2 97.89 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (174123030..174137229, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (174281237..174295436, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long noncoding RNA Nespas inhibits apoptosis of epileptiform hippocampal neurons by inhibiting the PI3K/Akt/mTOR pathway.
Title: Long noncoding RNA Nespas inhibits apoptosis of epileptiform hippocampal neurons by inhibiting the PI3K/Akt/mTOR pathway.
Nespas gene, encoding a transcript anti-sense to Nesp, is imprinted with exclusive expression from the paternal allele, unlike Nesp, which is maternally expressed.
Title: An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus.
Nespas differentially methylated region is the imprinting control regions at the Gnas cluster and functions bidirectionally as aswitch for modulating expression of the antagonistically acting genes Gnasxl and Gnas
Title: Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

General gene information

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Other Names

neuroendocrine secretory protein antisense
neuroendocrine secretory protein opposite strand

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within genomic imprinting	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.