plce1 phospholipase C, epsilon 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: plce1provided by ZNC
Official Full Name: phospholipase C, epsilon 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-061212-4
See related: Ensembl:ENSDARG00000087921 AllianceGenome:ZFIN:ZDB-GENE-061212-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and phosphatidylinositol phospholipase C activity. Acts upstream of or within glomerular basement membrane development. Is expressed in several structures, including brain; digestive system; muscle; notochord; and pronephric glomerulus. Human ortholog(s) of this gene implicated in nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3. Orthologous to human PLCE1 (phospholipase C epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (5240466..5399690)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (5205522..5363945)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that zebrafish may be used as a model organism to address the function of PLCepsilon 1 during the development of organs.
Title: Molecular cloning and expression of phospholipase C epsilon 1 in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fi40f08.x1 (e-PCR)
- UniSTS:197473

G45321 (e-PCR)
- UniSTS:106123

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glomerular basement membrane development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glomerulus development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

NP_001155125.1

EC 3.1.4.11

XP_021335822.1

EC 3.1.4.11

XP_021335823.1

EC 3.1.4.11

XP_021335824.1

EC 3.1.4.11

XP_021335825.1

EC 3.1.4.11

XP_021335826.1

EC 3.1.4.11

XP_021335827.1

EC 3.1.4.11

XP_021335828.1

EC 3.1.4.11

XP_021335829.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161653.1 → NP_001155125.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

See identical proteins and their annotated locations for NP_001155125.1

Status: PROVISIONAL

Source sequence(s)

EU919685

UniProtKB/TrEMBL

C5H807

Related

ENSDARP00000112202.2, ENSDART00000124097.3

Conserved Domains (6) summary

cd00275
Location:1831 → 1946

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd01780
Location:2092 → 2191

PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase

cd08596
Location:1359 → 1796

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

PLN02222
Location:1292 → 1933

PLN02222; phosphoinositide phospholipase C 2

pfam00617
Location:483 → 668

RasGEF; RasGEF domain

pfam09279
Location:1292 → 1347

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

5240466..5399690

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480147.1 → XP_021335822.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

UniProtKB/TrEMBL

A0A8M9PWG9

Conserved Domains (5) summary

cd01780
Location:2106 → 2205

PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase

cd08596
Location:1359 → 1810

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

pfam00617
Location:483 → 668

RasGEF; RasGEF domain

cd16203
Location:1166 → 1346

EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)

cl27705
Location:1355 → 1960

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
XM_021480148.1 → XP_021335823.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

UniProtKB/TrEMBL

A0A8M9Q8J1

Conserved Domains (5) summary

cd01780
Location:2105 → 2204

PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase

cd08596
Location:1359 → 1810

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

pfam00617
Location:483 → 668

RasGEF; RasGEF domain

cd16203
Location:1166 → 1346

EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)

cl27705
Location:1355 → 1960

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
XM_021480150.1 → XP_021335825.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

UniProtKB/TrEMBL

A0A8M9QML6

Conserved Domains (5) summary

cd01780
Location:2092 → 2191

PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase

cd08596
Location:1359 → 1796

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

pfam00617
Location:483 → 668

RasGEF; RasGEF domain

cd16203
Location:1166 → 1346

EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)

cl27705
Location:1355 → 1946

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
XM_021480149.1 → XP_021335824.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/TrEMBL

A0A8M9QED9

Conserved Domains (5) summary

cd01780
Location:2097 → 2196

PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase

cd08596
Location:1350 → 1801

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

pfam00617
Location:483 → 668

RasGEF; RasGEF domain

cd16203
Location:1157 → 1337

EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)

cl27705
Location:1346 → 1951

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
XM_021480154.1 → XP_021335829.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X8

UniProtKB/TrEMBL

A0A8M9QEE4

Conserved Domains (5) summary

cd01780
Location:2082 → 2181

PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase

cd08596
Location:1350 → 1787

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

pfam00617
Location:483 → 668

RasGEF; RasGEF domain

cd16203
Location:1157 → 1337

EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)

cl27705
Location:1346 → 1937

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
XM_021480151.1 → XP_021335826.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

UniProtKB/TrEMBL

A0A8M9QIU6

Conserved Domains (5) summary

cd01780
Location:2106 → 2205

PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase

cd08596
Location:1359 → 1810

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

pfam00617
Location:483 → 668

RasGEF; RasGEF domain

cd16203
Location:1166 → 1346

EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)

cl27705
Location:1355 → 1960

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
XM_021480152.1 → XP_021335827.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6

UniProtKB/TrEMBL

A0A8M9PWH5

Conserved Domains (5) summary

cd01780
Location:2092 → 2191

PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase

cd08596
Location:1359 → 1796

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

pfam00617
Location:483 → 668

RasGEF; RasGEF domain

cd16203
Location:1166 → 1346

EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)

cl27705
Location:1355 → 1946

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
XM_021480153.1 → XP_021335828.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X7

UniProtKB/TrEMBL

A0A8M9Q8J6

Conserved Domains (5) summary

cd01780
Location:1695 → 1794

PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase

cd08596
Location:948 → 1399

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

pfam00617
Location:72 → 257

RasGEF; RasGEF domain

cd16203
Location:755 → 935

EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)

cl27705
Location:944 → 1549

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain