CD177 CD177 molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD177provided by HGNC
Official Full Name: CD177 moleculeprovided by HGNC
Primary source: HGNC:HGNC:30072
See related: Ensembl:ENSG00000204936 MIM:162860; AllianceGenome:HGNC:30072
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP
Summary: This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
Expression: Biased expression in bone marrow (RPKM 83.5), colon (RPKM 72.9) and 1 other tissue See more
Orthologs: all
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Genomic context

Location:: 19q13.31

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (43353686..43366081)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (46174138..46186504)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (43857838..43867324)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The CD177 c.1291A Allele Leads to a Loss of Membrane Expression and Mimics a CD177-Null Phenotype.
Title: The CD177 c.1291A Allele Leads to a Loss of Membrane Expression and Mimics a CD177-Null Phenotype.
Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer.
Title: Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer.
Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation.
Title: Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation.
The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology.
Title: The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
Title: CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
Characterization of CD177-reactive iso- and auto-antibodies.
Title: Characterization of CD177-reactive iso- and auto-antibodies.
Relationship between CD177 and the vasculogenic mimicry, clinicopathological parameters, and prognosis of epithelial ovarian cancer.
Title: Relationship between CD177 and the vasculogenic mimicry, clinicopathological parameters, and prognosis of epithelial ovarian cancer.
The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in periodontitis.
Title: The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in periodontitis.
Cancer cell-intrinsic function of CD177 in attenuating beta-catenin signaling.
Title: Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling.
A novel nonsense mutation found in the CD177 gene of Thai individuals with the HNA-2 null phenotype.
Title: A novel nonsense mutation found in the CD177 gene of Thai individuals with the HNA-2 null phenotype.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell junction maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil degranulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neutrophil degranulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of superoxide anion generation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in plasma membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info
located_in specific granule membrane	TAS Traceable Author Statement more info
located_in tertiary granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in tertiary granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: CD177 antigen

Names: NB1 glycoprotein; cell surface receptor; human neutrophil alloantigen 2a; polycythemia rubra vera protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020406.4 → NP_065139.2 CD177 antigen precursor

See identical proteins and their annotated locations for NP_065139.2

Status: REVIEWED

Source sequence(s)

AK225226, AY358932, BC029167, BU688145, CD514938, DA728784, DB323632

Consensus CDS

CCDS62700.1

UniProtKB/Swiss-Prot

Q711Q2, Q8N6Q3, Q8NCV9, Q96QH1, Q9HDA5

UniProtKB/TrEMBL

A0A087WVM2

Related

ENSP00000479536.1, ENST00000618265.5

Conserved Domains (2) summary

pfam00021
Location:133 → 203

UPAR_LY6; u-PAR/Ly-6 domain

cl10471
Location:325 → 394

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...