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PTGDS prostaglandin D2 synthase [ Homo sapiens (human) ]

Gene ID: 5730, updated on 4-Jan-2025

Summary

Official Symbol
PTGDSprovided by HGNC
Official Full Name
prostaglandin D2 synthaseprovided by HGNC
Primary source
HGNC:HGNC:9592
See related
Ensembl:ENSG00000107317 MIM:176803; AllianceGenome:HGNC:9592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS
Summary
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 1025.8), heart (RPKM 481.7) and 13 other tissues See more
Orthologs
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Genomic context

See PTGDS in Genome Data Viewer
Location:
9q34.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (136977504..136981742)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149211911..149216153)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139871956..139876194)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2692 Neighboring gene uncharacterized LOC124902312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139873016-139873995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139878783-139879340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139879341-139879896 Neighboring gene lipocalin like 1 Neighboring gene Sharpr-MPRA regulatory region 3127 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20564 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20565 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139887067-139887609 Neighboring gene PAXX non-homologous end joining factor

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
EBI GWAS Catalog
Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA increases PTGDS mRNA expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Potential readthrough

Included gene: LCNL1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty acid binding PubMed 
enables prostaglandin-D synthase activity PubMed 
enables prostaglandin-D synthase activity  
enables prostaglandin-D synthase activity  
enables protein binding PubMed 
enables retinoid binding  
Process Evidence Code Pubs
involved_in cyclooxygenase pathway  
involved_in gene expression  
involved_in mast cell degranulation  
involved_in negative regulation of male germ cell proliferation  
involved_in prostaglandin biosynthetic process PubMed 
involved_in prostaglandin biosynthetic process  
involved_in regulation of circadian sleep/wake cycle, sleep  
involved_in response to glucocorticoid  
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in endoplasmic reticulum membrane  
located_in extracellular exosome PubMed 
located_in extracellular region PubMed 
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in nuclear membrane  
located_in perinuclear region of cytoplasm  
located_in rough endoplasmic reticulum PubMed 

General protein information

Preferred Names
prostaglandin-H2 D-isomerase
Names
PGD2 synthase
beta-trace protein
cerebrin-28
glutathione-independent PGD synthase
glutathione-independent PGD synthetase
lipocalin-type prostaglandin D synthase
prostaglandin D synthase
prostaglandin D2 synthase 21kDa (brain)
testis tissue sperm-binding protein Li 63n
NP_000945.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000954.6NP_000945.3  prostaglandin-H2 D-isomerase precursor

    See identical proteins and their annotated locations for NP_000945.3

    Status: REVIEWED

    Source sequence(s)
    AL807752
    Consensus CDS
    CCDS7019.1
    UniProtKB/Swiss-Prot
    B2R727, P41222, Q5SQ10, Q7M4P3, Q9UC22, Q9UCC9, Q9UCD9
    UniProtKB/TrEMBL
    A0A024R8G3, Q5SQ11
    Related
    ENSP00000360687.3, ENST00000371625.8
    Conserved Domains (1) summary
    pfam00061
    Location:40184
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    136977504..136981742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    149211911..149216153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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