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Serinc4 serine incorporator 4 [ Mus musculus (house mouse) ]

Gene ID: 574418, updated on 11-Apr-2024

Summary

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Official Symbol
Serinc4provided by MGI
Official Full Name
serine incorporator 4provided by MGI
Primary source
MGI:MGI:2441842
See related
Ensembl:ENSMUSG00000046110 AllianceGenome:MGI:2441842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930015D22Rik
Summary
Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human SERINC4 (serine incorporator 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 75.9), large intestine adult (RPKM 55.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Serinc4 in Genome Data Viewer
Location:
2 E5; 2 60.39 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121281658..121287245, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121451177..121456764, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cation channel, sperm associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E9202 Neighboring gene protein disulfide isomerase associated 3 Neighboring gene STARR-positive B cell enhancer ABC_E3397 Neighboring gene elongation factor RNA polymerase II-like 3 Neighboring gene STARR-positive B cell enhancer ABC_E3398 Neighboring gene small EDRK-rich factor 2 Neighboring gene huntingtin interacting protein K Neighboring gene microfibrillar-associated protein 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis. Inuzuka M, et al. J Biol Chem, 2005 Oct 21. PMID 16120614
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine incorporator 4
Names
ortholog of serine incorporator 4 SERINC4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025371.2 → NP_001020542.1  serine incorporator 4 isoform 1

    See identical proteins and their annotated locations for NP_001020542.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC083132
    Consensus CDS
    CCDS16646.1
    UniProtKB/Swiss-Prot
    Q5XK03, Q8C8U1
    Related
    ENSMUSP00000051261.4, ENSMUST00000056312.10
    Conserved Domains (1) summary
    pfam03348
    Location:36 → 471
    Serinc; Serine incorporator (Serinc)

  2. NM_001363097.1 → NP_001350026.1  serine incorporator 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL845466, BC026459
    Consensus CDS
    CCDS89545.1
    UniProtKB/TrEMBL
    A2ARQ6
    Related
    ENSMUSP00000106243.3, ENSMUST00000110613.9
    Conserved Domains (1) summary
    pfam03348
    Location:35 → 276
    Serinc; Serine incorporator (Serinc)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121281658..121287245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319149.3 → XP_017174638.1  serine incorporator 4 isoform X1

    Conserved Domains (1) summary
    pfam03348
    Location:32 → 232
    Serinc; Serine incorporator (Serinc)

RNA

  1. XR_001783158.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XK03.1 GenPept UniProtKB/Swiss-Prot:Q5XK03

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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