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Lair1 leukocyte-associated immunoglobulin-like receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 574531, updated on 11-Apr-2024

Summary

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Official Symbol
Lair1provided by RGD
Official Full Name
leukocyte-associated immunoglobulin-like receptor 1provided by RGD
Primary source
RGD:1560048
See related
Ensembl:ENSRNOG00000027733 AllianceGenome:RGD:1560048
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including LAIR1 (leukocyte associated immunoglobulin like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 15.4), Kidney (RPKM 12.8) and 8 other tissues See more
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Genomic context

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Location:
1q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (79140850..79261546)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (70068571..70187851)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (73752192..73870421)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene CDC42 effector protein 5 Neighboring gene leukocyte receptor cluster member 9 Neighboring gene leukocyte receptor cluster member 8 Neighboring gene tweety family member 1 Neighboring gene uncharacterized LOC134482886 Neighboring gene uncharacterized LOC134484886

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of the rat homologue of LAIR-1. Lebbink RJ, et al. Immunogenetics, 2005 Jun. PMID 15902436
  2. Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion. Peng DH, et al. Nat Commun, 2020 Sep 9. PMID 32908154, Free PMC Article
  3. Molecular cloning of LILRC1 and LILRC2 in the mouse and the rat, two novel immunoglobulin-like receptors encoded by the leukocyte receptor gene complex. Hoelsbrekken SE, et al. Immunogenetics, 2005 Aug. PMID 16041585
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion.
    Title: Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leukocyte-associated immunoglobulin-like receptor 1
Names
LAIR-1
leukocyte-associated Ig-like receptor 1
rLAIR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029928.1 → NP_001025099.1  leukocyte-associated immunoglobulin-like receptor 1 precursor

    See identical proteins and their annotated locations for NP_001025099.1

    Status: PROVISIONAL

    Source sequence(s)
    AY863023
    UniProtKB/Swiss-Prot
    P0C1X9
    UniProtKB/TrEMBL
    A6KNI4
    Related
    ENSRNOP00000037815.4, ENSRNOT00000036413.5
    Conserved Domains (1) summary
    cl11960
    Location:30 → 115
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    79140850..79261546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272104.1 → XP_063128174.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X2

  2. XM_017589623.3 → XP_017445112.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P0C1X9
    UniProtKB/TrEMBL
    A6KNI4
    Conserved Domains (1) summary
    cl11960
    Location:30 → 115
    Ig; Immunoglobulin domain

  3. XM_017589620.3 → XP_017445109.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P0C1X9
    UniProtKB/TrEMBL
    A6KNI4
    Conserved Domains (1) summary
    cl11960
    Location:30 → 115
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C1X9.1 GenPept UniProtKB/Swiss-Prot:P0C1X9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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