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PTK2 protein tyrosine kinase 2 [ Homo sapiens (human) ]

Gene ID: 5747, updated on 11-Apr-2024

Summary

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Official Symbol
PTK2provided by HGNC
Official Full Name
protein tyrosine kinase 2provided by HGNC
Primary source
HGNC:HGNC:9611
See related
Ensembl:ENSG00000169398 MIM:600758; AllianceGenome:HGNC:9611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAK; FADK; FAK1; FRNK; FADK 1; PPP1R71; p125FAK; pp125FAK
Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Expression
Ubiquitous expression in brain (RPKM 21.7), placenta (RPKM 17.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
8q24.3
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (140657900..141002079, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (141777902..142122150, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (141667999..142012178, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene argonaute RISC catalytic component 2 Neighboring gene MAGE-like protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141634221-141635220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141635221-141636221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141640637-141641137 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141643203-141643970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141643971-141644737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19583 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:141655407-141656606 Neighboring gene uncharacterized LOC124902099 Neighboring gene E2F1-regulated inhibitor of cell death Neighboring gene microRNA 151a Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:141901324-141901954 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:141901955-141902583 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:141903275-141903488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141959143-141960131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28038 Neighboring gene RNA, 5S ribosomal pseudogene 278 Neighboring gene Sharpr-MPRA regulatory region 10587 Neighboring gene NANOG hESC enhancer GRCh37_chr8:141986399-141986923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142026737-142027298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142030905-142031616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142032328-142033038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142033039-142033749 Neighboring gene uncharacterized LOC105375783 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:142036197-142037048 and GRCh37_chr8:142037049-142037899 Neighboring gene uncharacterized LOC124902030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142047320-142047944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142047945-142048570

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FAK downregulation suppresses stem-like properties and migration of human colorectal cancer cells. Xu C, et al. PLoS One, 2023. PMID 37083591, Free PMC Article
  2. Dual roles of FAK in tumor angiogenesis: A review focused on pericyte FAK. Zhang J, et al. Eur J Pharmacol, 2023 May 15. PMID 36967077
  3. Oxidative stress-induced FAK activation contributes to uterine serous carcinoma aggressiveness. Lopez-Mejia IC, et al. Mol Oncol, 2023 Jan. PMID 36409196, Free PMC Article
  4. Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy. Murphy KJ, et al. Biochem Soc Trans, 2022 Aug 31. PMID 35929603, Free PMC Article
  5. Decreased FAK activity and focal adhesion dynamics impair proper neurite formation of medium spiny neurons in Huntington's disease. Lee HN, et al. Acta Neuropathol, 2022 Sep. PMID 35857122

See all (1050) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A decrease in integrin alpha5beta1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection.
    Title: A decrease in integrin α5β1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection.
  2. ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.
    Title: ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.
  3. FAK mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation by modulating mitochondrial transcription termination factor 1/cyclin D1.
    Title: FAK mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation by modulating mitochondrial transcription termination factor 1/cyclin D1.
  4. ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.
    Title: ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.
  5. THSD1 Suppresses Autophagy-Mediated Focal Adhesion Turnover by Modulating the FAK-Beclin 1 Pathway.
    Title: THSD1 Suppresses Autophagy-Mediated Focal Adhesion Turnover by Modulating the FAK-Beclin 1 Pathway.
  6. Exploring the therapeutic potential of focal adhesion kinase inhibition in overcoming chemoresistance in pancreatic ductal adenocarcinoma.
    Title: Exploring the therapeutic potential of focal adhesion kinase inhibition in overcoming chemoresistance in pancreatic ductal adenocarcinoma.
  7. DPP-4 exacerbates LPS-induced endothelial cells inflammation via integrin-alpha5beta1/FAK/AKT signaling.
    Title: DPP-4 exacerbates LPS-induced endothelial cells inflammation via integrin-α5β1/FAK/AKT signaling.
  8. ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma.
    Title: ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma.
  9. VPS35 promotes gastric cancer progression through integrin/FAK/SRC signalling-mediated IL-6/STAT3 pathway activation in a YAP-dependent manner.
    Title: VPS35 promotes gastric cancer progression through integrin/FAK/SRC signalling-mediated IL-6/STAT3 pathway activation in a YAP-dependent manner.
  10. High frequency of alternative splicing variants of the oncogene Focal Adhesion Kinase in neuroendocrine tumors of the pancreas and breast.
    Title: High frequency of alternative splicing variants of the oncogene Focal Adhesion Kinase in neuroendocrine tumors of the pancreas and breast.
Submit: New GeneRIF Correction See all GeneRIFs (778)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-stimulated cells overexpressing NHERF1 upregulates FAK phosphorylation PubMed
env Focal adhesion kinase (FAK), CD4, and HIV-1 gp120 co-localize in T cells. The formation of FAK-CD4 complex is induced by gp120 PubMed
Tat tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
tat Focal adhesion kinase (FAK) is tyrosine-phosphorylated by Tat, and inhibition of FAK by the dominant interfering mutant form, FAK-related nonkinase, significantly blocks HBMEC migration and disrupted focal adhesions upon Tat activation PubMed
tat HIV-1 Tat upregulates p125FAK and induces the tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 neuronal cells PubMed
tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables JUN kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables SH2 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular function activator activity EXP
Inferred from Experiment
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
enables protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
  
involved_in angiogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in axon guidance TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell motility TAS
Traceable Author Statement
more info
 PubMed 
involved_in detection of muscle stretch TAS
Traceable Author Statement
more info
 PubMed 
involved_in ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of cell polarity TAS
Traceable Author Statement
more info
 PubMed 
involved_in growth hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heart morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in integrin-mediated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in netrin-activated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in placenta development TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of epithelial cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of fibroblast migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of positive regulation of macrophage chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of positive regulation of macrophage proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of wound healing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of endothelial cell migration TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of epithelial cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of focal adhesion assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of focal adhesion assembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of substrate adhesion-dependent cell spreading IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  
located_in cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
focal adhesion kinase 1
Names
FAK-related non-kinase polypeptide
PTK2 protein tyrosine kinase 2
focal adhesion kinase-related nonkinase
protein phosphatase 1 regulatory subunit 71
NP_001186578.1
NP_001303271.1
NP_001339623.1
NP_001339624.1
NP_001339625.1
NP_001339626.1
NP_001339627.1
NP_001339628.1
NP_001339629.1
NP_001339630.1
NP_001339631.1
NP_001339632.1
NP_001339633.1
NP_001339634.1
NP_001339635.1
NP_001339636.1
NP_001339637.1
NP_001339638.1
NP_001339639.1
NP_001339640.1
NP_001339641.1
NP_001339642.1
NP_001339643.1
NP_001339644.1
NP_001339645.1
NP_001339646.1
NP_001339647.1
NP_001339648.1
NP_001339649.1
NP_001339650.1
NP_001339651.1
NP_001339652.1
NP_001339653.1
NP_001339654.1
NP_001339655.1
NP_001339656.1
NP_001339657.1
NP_001339658.1
NP_001339659.1
NP_001339660.1
NP_001339661.1
NP_001339662.1
NP_001339663.1
NP_001339664.1
NP_001339665.1
NP_001339666.1
NP_001339667.1
NP_001339668.1
NP_001339669.1
NP_001339670.1
NP_001339671.1
NP_001339672.1
NP_001339673.1
NP_001339674.1
NP_001339675.1
NP_001339676.1
NP_001339677.1
NP_001339678.1
NP_001339679.1
NP_001339680.1
NP_001339681.1
NP_001374513.1
NP_001374514.1
NP_001374515.1
NP_001374516.1
NP_001374517.1
NP_001374518.1
NP_001374519.1
NP_001374520.1
NP_001374521.1
NP_001374532.1
NP_001374533.1
NP_001374534.1
NP_001374535.1
NP_001374536.1
NP_001374537.1
NP_001374538.1
NP_001374539.1
NP_001374540.1
NP_001374541.1
NP_001374542.1
NP_001374543.1
NP_001374544.1
NP_001374545.1
NP_001374546.1
NP_001374547.1
NP_001374548.1
NP_001374549.1
NP_001374550.1
NP_001374551.1
NP_001374552.1
NP_001374553.1
NP_001374554.1
NP_001374556.1
NP_001374557.1
NP_001374558.1
NP_001374559.1
NP_001374560.1
NP_001374561.1
NP_001374562.1
NP_001374563.1
NP_001374564.1
NP_001374565.1
NP_001374566.1
NP_001374567.1
NP_001374568.1
NP_001374569.1
NP_001374570.1
NP_001374571.1
NP_001374572.1
NP_001374573.1
NP_001374574.1
NP_001374575.1
NP_001374576.1
NP_001374577.1
NP_001374578.1
NP_001374579.1
NP_001374580.1
NP_001374581.1
NP_001374582.1
NP_001374583.1
NP_001374584.1
NP_001374585.1
NP_001374586.1
NP_001374587.1
NP_001374588.1
NP_001374589.1
NP_001374590.1
NP_001374591.1
NP_005598.3
NP_722560.1
XP_024302970.1
XP_024302971.1
XP_024302975.1
XP_024302976.1
XP_024302977.1
XP_047277972.1
XP_047277973.1
XP_047277974.1
XP_047277975.1
XP_047277976.1
XP_047277977.1
XP_047277978.1
XP_047277979.1
XP_047277980.1
XP_047277981.1
XP_047277982.1
XP_047277983.1
XP_047277984.1
XP_047277985.1
XP_047277986.1
XP_047277987.1
XP_047277988.1
XP_047277989.1
XP_047277990.1
XP_047277991.1
XP_047277992.1
XP_047277993.1
XP_047277994.1
XP_047277995.1
XP_047277996.1
XP_047277997.1
XP_047277999.1
XP_047278000.1
XP_047278001.1
XP_047278002.1
XP_047278003.1
XP_047278004.1
XP_047278005.1
XP_047278006.1
XP_047278008.1
XP_047278009.1
XP_047278010.1
XP_054216858.1
XP_054216859.1
XP_054216860.1
XP_054216861.1
XP_054216862.1
XP_054216863.1
XP_054216864.1
XP_054216865.1
XP_054216866.1
XP_054216867.1
XP_054216868.1
XP_054216869.1
XP_054216870.1
XP_054216871.1
XP_054216872.1
XP_054216873.1
XP_054216874.1
XP_054216875.1
XP_054216876.1
XP_054216877.1
XP_054216878.1
XP_054216879.1
XP_054216880.1
XP_054216881.1
XP_054216882.1
XP_054216883.1
XP_054216884.1
XP_054216885.1
XP_054216886.1
XP_054216887.1
XP_054216888.1
XP_054216889.1
XP_054216890.1
XP_054216891.1
XP_054216892.1
XP_054216893.1
XP_054216894.1
XP_054216895.1
XP_054216896.1
XP_054216897.1
XP_054216898.1
XP_054216899.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029467.2 RefSeqGene

    Range
    5032..348414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199649.2 → NP_001186578.1  focal adhesion kinase 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence, and contains two additional in-frame segments near the 3' end of the coding sequence, compared to variant 2. The resulting isoform (c) is shorter at the N-terminus and contains two additional segments in the C-terminus compared to isoform b.
    Source sequence(s)
    AB209083, AC067931, AK304356, AL832961, BF434494, DA236314, DA994616
    Consensus CDS
    CCDS56557.1
    UniProtKB/TrEMBL
    A0A059VC25
    Related
    ENSP00000341189.3, ENST00000340930.7
    Conserved Domains (6) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:143 → 248
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:929 → 1058
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:422 → 676
    Pkinase_Tyr; Protein tyrosine kinase

  2. NM_001316342.2 → NP_001303271.1  focal adhesion kinase 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons and contains two other alternate in-frame exons compared to variant 2. The resulting isoform (d) differs in the 5' UTR, has a shorter and distinct N-terminus, and contains two alternative segments compared to isoform b. Variants 4 and 7 both encode the same isoform (d).
    Source sequence(s)
    AB209071, AC067931, BF434494, BY800117
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:315 → 584
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:819 → 948
    Focal_AT; Focal adhesion targeting region

  3. NM_001352694.2 → NP_001339623.1  focal adhesion kinase 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 1, encodes isoform a.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:916 → 1045
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  4. NM_001352695.2 → NP_001339624.1  focal adhesion kinase 1 isoform 48

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:449 → 718
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:929 → 1058
    Focal_AT; Focal adhesion targeting region

  5. NM_001352696.2 → NP_001339625.1  focal adhesion kinase 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 4, encodes isoform d.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:315 → 584
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:819 → 948
    Focal_AT; Focal adhesion targeting region

  6. NM_001352697.2 → NP_001339626.1  focal adhesion kinase 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:500 → 769
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:980 → 1109
    Focal_AT; Focal adhesion targeting region

  7. NM_001352698.2 → NP_001339627.1  focal adhesion kinase 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:469 → 738
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:49 → 271
    B41; Band 4.1 homologues
    cd13190
    Location:267 → 377
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:973 → 1102
    Focal_AT; Focal adhesion targeting region

  8. NM_001352699.2 → NP_001339628.1  focal adhesion kinase 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 11-14, encodes isoform g.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS94346.1
    UniProtKB/TrEMBL
    A0A059VC25, A0A8Q3WLM4
    Conserved Domains (4) summary
    cd05056
    Location:456 → 725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:960 → 1089
    Focal_AT; Focal adhesion targeting region

  9. NM_001352700.2 → NP_001339629.1  focal adhesion kinase 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 10 and 12-14, encodes isoform g.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS94346.1
    UniProtKB/TrEMBL
    A0A059VC25, A0A8Q3WLM4
    Conserved Domains (4) summary
    cd05056
    Location:456 → 725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:960 → 1089
    Focal_AT; Focal adhesion targeting region

  10. NM_001352701.2 → NP_001339630.1  focal adhesion kinase 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 10, 11, 13, and 14, encodes isoform g.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS94346.1
    UniProtKB/TrEMBL
    A0A059VC25, A0A8Q3WLM4
    Conserved Domains (4) summary
    cd05056
    Location:456 → 725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:960 → 1089
    Focal_AT; Focal adhesion targeting region

  11. NM_001352702.2 → NP_001339631.1  focal adhesion kinase 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 10-12 and 14, encodes isoform g.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS94346.1
    UniProtKB/TrEMBL
    A0A059VC25, A0A8Q3WLM4
    Related
    ENSP00000512868.1, ENST00000696786.1
    Conserved Domains (4) summary
    cd05056
    Location:456 → 725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:960 → 1089
    Focal_AT; Focal adhesion targeting region

  12. NM_001352703.2 → NP_001339632.1  focal adhesion kinase 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 10-13, encodes isoform g.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS94346.1
    UniProtKB/TrEMBL
    A0A059VC25, A0A8Q3WLM4
    Conserved Domains (4) summary
    cd05056
    Location:456 → 725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:960 → 1089
    Focal_AT; Focal adhesion targeting region

  13. NM_001352704.2 → NP_001339633.1  focal adhesion kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:449 → 718
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:953 → 1082
    Focal_AT; Focal adhesion targeting region

  14. NM_001352705.2 → NP_001339634.1  focal adhesion kinase 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:441 → 710
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:49 → 271
    B41; Band 4.1 homologues
    cd13190
    Location:267 → 377
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:945 → 1074
    Focal_AT; Focal adhesion targeting region

  15. NM_001352706.2 → NP_001339635.1  focal adhesion kinase 1 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 18-21, encodes isoform j.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:428 → 697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:932 → 1061
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  16. NM_001352707.2 → NP_001339636.1  focal adhesion kinase 1 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 17 and 19-21, encodes isoform j.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:428 → 697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:932 → 1061
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  17. NM_001352708.2 → NP_001339637.1  focal adhesion kinase 1 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 17,18, 20, and 21, encodes isoform j.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:428 → 697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:932 → 1061
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  18. NM_001352709.2 → NP_001339638.1  focal adhesion kinase 1 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 17-19 and 21, encodes isoform j.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:428 → 697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:932 → 1061
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  19. NM_001352710.2 → NP_001339639.1  focal adhesion kinase 1 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 17-20, encodes isoform j.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:428 → 697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:932 → 1061
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  20. NM_001352711.2 → NP_001339640.1  focal adhesion kinase 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:427 → 696
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:931 → 1060
    Focal_AT; Focal adhesion targeting region

  21. NM_001352712.2 → NP_001339641.1  focal adhesion kinase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:456 → 725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:957 → 1086
    Focal_AT; Focal adhesion targeting region

  22. NM_001352713.2 → NP_001339642.1  focal adhesion kinase 1 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variant 25, encodes isoform m.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:422 → 691
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:926 → 1055
    Focal_AT; Focal adhesion targeting region

  23. NM_001352714.2 → NP_001339643.1  focal adhesion kinase 1 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variant 24, encodes isoform m.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:422 → 691
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:926 → 1055
    Focal_AT; Focal adhesion targeting region

  24. NM_001352715.2 → NP_001339644.1  focal adhesion kinase 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:421 → 690
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:925 → 1054
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  25. NM_001352716.2 → NP_001339645.1  focal adhesion kinase 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:420 → 689
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:924 → 1053
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  26. NM_001352717.2 → NP_001339646.1  focal adhesion kinase 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:421 → 690
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:922 → 1051
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  27. NM_001352718.2 → NP_001339647.1  focal adhesion kinase 1 isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variants 30 and 31, encodes isoform q.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:919 → 1048
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  28. NM_001352719.2 → NP_001339648.1  focal adhesion kinase 1 isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 29 and 31, encodes isoform q.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:919 → 1048
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  29. NM_001352720.2 → NP_001339649.1  focal adhesion kinase 1 isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variants 29 and 30, encodes isoform q.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:919 → 1048
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  30. NM_001352721.2 → NP_001339650.1  focal adhesion kinase 1 isoform 18

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variants 33 and 34, encodes isoform r.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:428 → 697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:911 → 1040
    Focal_AT; Focal adhesion targeting region

  31. NM_001352722.2 → NP_001339651.1  focal adhesion kinase 1 isoform 18

    Status: REVIEWED

    Description
    Transcript Variant: This variant (33), as well as variants 32 and 34, encodes isoform r.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:428 → 697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:911 → 1040
    Focal_AT; Focal adhesion targeting region

  32. NM_001352723.2 → NP_001339652.1  focal adhesion kinase 1 isoform 18

    Status: REVIEWED

    Description
    Transcript Variant: This variant (34), as well as variants 32 and 33, encodes isoform r.
    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:428 → 697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:911 → 1040
    Focal_AT; Focal adhesion targeting region

  33. NM_001352724.2 → NP_001339653.1  focal adhesion kinase 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:428 → 697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:932 → 1034
    Focal_AT; Focal adhesion targeting region

  34. NM_001352725.2 → NP_001339654.1  focal adhesion kinase 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:898 → 1027
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  35. NM_001352726.2 → NP_001339655.1  focal adhesion kinase 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:392 → 661
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:896 → 1025
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  36. NM_001352727.2 → NP_001339656.1  focal adhesion kinase 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:428 → 697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:911 → 1013
    Focal_AT; Focal adhesion targeting region

  37. NM_001352728.2 → NP_001339657.1  focal adhesion kinase 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:379 → 648
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:880 → 1009
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  38. NM_001352729.2 → NP_001339658.1  focal adhesion kinase 1 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:392 → 661
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:875 → 1004
    Focal_AT; Focal adhesion targeting region

  39. NM_001352730.2 → NP_001339659.1  focal adhesion kinase 1 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GM6
    Conserved Domains (4) summary
    cd05056
    Location:343 → 612
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:847 → 976
    Focal_AT; Focal adhesion targeting region

  40. NM_001352731.2 → NP_001339660.1  focal adhesion kinase 1 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GM6
    Conserved Domains (4) summary
    cd05056
    Location:343 → 612
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:845 → 974
    Focal_AT; Focal adhesion targeting region

  41. NM_001352732.2 → NP_001339661.1  focal adhesion kinase 1 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GM6
    Conserved Domains (4) summary
    cd05056
    Location:343 → 612
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:844 → 973
    Focal_AT; Focal adhesion targeting region

  42. NM_001352733.2 → NP_001339662.1  focal adhesion kinase 1 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GM6
    Conserved Domains (4) summary
    cd05056
    Location:336 → 605
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:840 → 969
    Focal_AT; Focal adhesion targeting region

  43. NM_001352734.2 → NP_001339663.1  focal adhesion kinase 1 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GM6
    Conserved Domains (4) summary
    cd05056
    Location:343 → 612
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:826 → 955
    Focal_AT; Focal adhesion targeting region

  44. NM_001352735.2 → NP_001339664.1  focal adhesion kinase 1 isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GM6
    Conserved Domains (4) summary
    cd05056
    Location:322 → 591
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 124
    B41; Band 4.1 homologues
    cd13190
    Location:120 → 230
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:826 → 955
    Focal_AT; Focal adhesion targeting region

  45. NM_001352736.2 → NP_001339665.1  focal adhesion kinase 1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:320 → 589
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:16 → 157
    B41; Band 4.1 homologues
    cd13190
    Location:153 → 263
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:824 → 953
    Focal_AT; Focal adhesion targeting region

  46. NM_001352737.2 → NP_001339666.1  focal adhesion kinase 1 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GM6
    Conserved Domains (4) summary
    cd05056
    Location:336 → 605
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:837 → 966
    Focal_AT; Focal adhesion targeting region

  47. NM_001352738.2 → NP_001339667.1  focal adhesion kinase 1 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:315 → 584
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:817 → 946
    Focal_AT; Focal adhesion targeting region

  48. NM_001352739.2 → NP_001339668.1  focal adhesion kinase 1 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:309 → 578
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:813 → 942
    Focal_AT; Focal adhesion targeting region

  49. NM_001352740.2 → NP_001339669.1  focal adhesion kinase 1 isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (3) summary
    cd05056
    Location:308 → 577
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

  50. NM_001352741.2 → NP_001339670.1  focal adhesion kinase 1 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:302 → 571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:806 → 935
    Focal_AT; Focal adhesion targeting region

  51. NM_001352742.2 → NP_001339671.1  focal adhesion kinase 1 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:294 → 563
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 124
    B41; Band 4.1 homologues
    cd13190
    Location:120 → 230
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:798 → 927
    Focal_AT; Focal adhesion targeting region

  52. NM_001352743.2 → NP_001339672.1  focal adhesion kinase 1 isoform 47

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:315 → 584
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:798 → 927
    Focal_AT; Focal adhesion targeting region

  53. NM_001352744.2 → NP_001339673.1  focal adhesion kinase 1 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:279 → 548
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 215
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:783 → 912
    Focal_AT; Focal adhesion targeting region

  54. NM_001352745.2 → NP_001339674.1  focal adhesion kinase 1 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:273 → 542
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 215
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:777 → 906
    Focal_AT; Focal adhesion targeting region

  55. NM_001352746.2 → NP_001339675.1  focal adhesion kinase 1 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:258 → 527
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 124
    B41; Band 4.1 homologues
    cd13190
    Location:120 → 194
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:762 → 891
    Focal_AT; Focal adhesion targeting region

  56. NM_001352747.2 → NP_001339676.1  focal adhesion kinase 1 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    E9PEI4
    Conserved Domains (2) summary
    pfam03623
    Location:445 → 574
    Focal_AT; Focal adhesion targeting region
    cl21453
    Location:1 → 210
    PKc_like; Protein Kinases, catalytic domain

  57. NM_001352748.2 → NP_001339677.1  focal adhesion kinase 1 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC100860, AC105009, AC105235
    Conserved Domains (3) summary
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cl21453
    Location:428 → 496
    PKc_like; Protein Kinases, catalytic domain

  58. NM_001352749.2 → NP_001339678.1  focal adhesion kinase 1 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC067931
    Conserved Domains (1) summary
    pfam03623
    Location:229 → 358
    Focal_AT; Focal adhesion targeting region

  59. NM_001352750.2 → NP_001339679.1  focal adhesion kinase 1 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC067931
    Consensus CDS
    CCDS87628.1
    UniProtKB/TrEMBL
    B4DWJ1
    Related
    ENSP00000403416.2, ENST00000430260.6
    Conserved Domains (1) summary
    pfam03623
    Location:226 → 355
    Focal_AT; Focal adhesion targeting region

  60. NM_001352751.2 → NP_001339680.1  focal adhesion kinase 1 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC067931
    Conserved Domains (1) summary
    pfam03623
    Location:208 → 337
    Focal_AT; Focal adhesion targeting region

  61. NM_001352752.2 → NP_001339681.1  focal adhesion kinase 1 isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC067931
    Conserved Domains (1) summary
    pfam03623
    Location:205 → 334
    Focal_AT; Focal adhesion targeting region

  62. NM_001387584.1 → NP_001374513.1  focal adhesion kinase 1 isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:302 → 571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:803 → 932
    Focal_AT; Focal adhesion targeting region

  63. NM_001387585.1 → NP_001374514.1  focal adhesion kinase 1 isoform 59

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:895 → 1024
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  64. NM_001387586.1 → NP_001374515.1  focal adhesion kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
    UniProtKB/TrEMBL
    A0A059VC25
    Related
    ENSP00000429929.1, ENST00000519654.5
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:916 → 1045
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  65. NM_001387587.1 → NP_001374516.1  focal adhesion kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:916 → 1045
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  66. NM_001387588.1 → NP_001374517.1  focal adhesion kinase 1 isoform 69

    Status: REVIEWED

    Source sequence(s)
    AC100860, AC105009
    Consensus CDS
    CCDS94345.1
    UniProtKB/TrEMBL
    E5RFW9, E5RI72
    Related
    ENSP00000430044.1, ENST00000520045.5
    Conserved Domains (1) summary
    pfam18038
    Location:35 → 121
    FERM_N_2; FERM N-terminal domain

  67. NM_001387589.1 → NP_001374518.1  focal adhesion kinase 1 isoform 70

    Status: REVIEWED

    Source sequence(s)
    AC100860, AC105009
    UniProtKB/TrEMBL
    E5RI72
    Conserved Domains (1) summary
    pfam18038
    Location:48 → 134
    FERM_N_2; FERM N-terminal domain

  68. NM_001387590.1 → NP_001374519.1  focal adhesion kinase 1 isoform 53

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:266 → 535
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 215
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:767 → 896
    Focal_AT; Focal adhesion targeting region

  69. NM_001387591.1 → NP_001374520.1  focal adhesion kinase 1 isoform 54

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:302 → 571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:782 → 911
    Focal_AT; Focal adhesion targeting region

  70. NM_001387592.1 → NP_001374521.1  focal adhesion kinase 1 isoform 71

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    H0YB16
    Related
    ENSP00000428492.1, ENST00000523539.5
    Conserved Domains (3) summary
    cd05056
    Location:101 → 370
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:602 → 731
    Focal_AT; Focal adhesion targeting region
    cl17171
    Location:1 → 50
    PH-like; Pleckstrin homology-like domain

  71. NM_001387603.1 → NP_001374532.1  focal adhesion kinase 1 isoform 55

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:302 → 571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:785 → 914
    Focal_AT; Focal adhesion targeting region

  72. NM_001387604.1 → NP_001374533.1  focal adhesion kinase 1 isoform 49

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    H0YB16
    Conserved Domains (3) summary
    cd05056
    Location:101 → 370
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:605 → 734
    Focal_AT; Focal adhesion targeting region
    cl17171
    Location:1 → 50
    PH-like; Pleckstrin homology-like domain

  73. NM_001387605.1 → NP_001374534.1  focal adhesion kinase 1 isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:302 → 571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:803 → 932
    Focal_AT; Focal adhesion targeting region

  74. NM_001387606.1 → NP_001374535.1  focal adhesion kinase 1 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:309 → 578
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:813 → 942
    Focal_AT; Focal adhesion targeting region

  75. NM_001387607.1 → NP_001374536.1  focal adhesion kinase 1 isoform 58

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:315 → 584
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:816 → 945
    Focal_AT; Focal adhesion targeting region

  76. NM_001387608.1 → NP_001374537.1  focal adhesion kinase 1 isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:302 → 571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:803 → 932
    Focal_AT; Focal adhesion targeting region

  77. NM_001387609.1 → NP_001374538.1  focal adhesion kinase 1 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:302 → 571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:806 → 935
    Focal_AT; Focal adhesion targeting region

  78. NM_001387610.1 → NP_001374539.1  focal adhesion kinase 1 isoform 52

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:241 → 510
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:18 → 84
    B41; Band 4.1 homologues
    cd13190
    Location:80 → 190
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:742 → 871
    Focal_AT; Focal adhesion targeting region

  79. NM_001387611.1 → NP_001374540.1  focal adhesion kinase 1 isoform 57

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:308 → 577
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:809 → 938
    Focal_AT; Focal adhesion targeting region

  80. NM_001387612.1 → NP_001374541.1  focal adhesion kinase 1 isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:302 → 571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:803 → 932
    Focal_AT; Focal adhesion targeting region

  81. NM_001387613.1 → NP_001374542.1  focal adhesion kinase 1 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:302 → 571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:806 → 935
    Focal_AT; Focal adhesion targeting region

  82. NM_001387614.1 → NP_001374543.1  focal adhesion kinase 1 isoform 59

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:895 → 1024
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  83. NM_001387615.1 → NP_001374544.1  focal adhesion kinase 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:392 → 661
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:896 → 1025
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  84. NM_001387616.1 → NP_001374545.1  focal adhesion kinase 1 isoform 71

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    H0YB16
    Conserved Domains (3) summary
    cd05056
    Location:101 → 370
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:602 → 731
    Focal_AT; Focal adhesion targeting region
    cl17171
    Location:1 → 50
    PH-like; Pleckstrin homology-like domain

  85. NM_001387617.1 → NP_001374546.1  focal adhesion kinase 1 isoform 71

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    H0YB16
    Conserved Domains (3) summary
    cd05056
    Location:101 → 370
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:602 → 731
    Focal_AT; Focal adhesion targeting region
    cl17171
    Location:1 → 50
    PH-like; Pleckstrin homology-like domain

  86. NM_001387618.1 → NP_001374547.1  focal adhesion kinase 1 isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:302 → 571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:803 → 932
    Focal_AT; Focal adhesion targeting region

  87. NM_001387619.1 → NP_001374548.1  focal adhesion kinase 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:379 → 648
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:880 → 1009
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  88. NM_001387620.1 → NP_001374549.1  focal adhesion kinase 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:315 → 584
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:819 → 948
    Focal_AT; Focal adhesion targeting region

  89. NM_001387621.1 → NP_001374550.1  focal adhesion kinase 1 isoform 71

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    H0YB16
    Conserved Domains (3) summary
    cd05056
    Location:101 → 370
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:602 → 731
    Focal_AT; Focal adhesion targeting region
    cl17171
    Location:1 → 50
    PH-like; Pleckstrin homology-like domain

  90. NM_001387622.1 → NP_001374551.1  focal adhesion kinase 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:421 → 690
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:922 → 1051
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  91. NM_001387623.1 → NP_001374552.1  focal adhesion kinase 1 isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:302 → 571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:803 → 932
    Focal_AT; Focal adhesion targeting region

  92. NM_001387624.1 → NP_001374553.1  focal adhesion kinase 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:420 → 689
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:924 → 1053
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  93. NM_001387625.1 → NP_001374554.1  focal adhesion kinase 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:898 → 1027
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  94. NM_001387627.1 → NP_001374556.1  focal adhesion kinase 1 isoform 60

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:421 → 690
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:901 → 1030
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  95. NM_001387628.1 → NP_001374557.1  focal adhesion kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
    UniProtKB/TrEMBL
    A0A059VC25
    Related
    ENSP00000429474.1, ENST00000521059.5
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:916 → 1045
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  96. NM_001387629.1 → NP_001374558.1  focal adhesion kinase 1 isoform 50

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    H0YB16
    Related
    ENSP00000430603.1, ENST00000521986.5
    Conserved Domains (3) summary
    cd05056
    Location:107 → 376
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    pfam03623
    Location:611 → 740
    Focal_AT; Focal adhesion targeting region
    cl17171
    Location:1 → 50
    PH-like; Pleckstrin homology-like domain

  97. NM_001387630.1 → NP_001374559.1  focal adhesion kinase 1 isoform 52

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:241 → 510
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:18 → 84
    B41; Band 4.1 homologues
    cd13190
    Location:80 → 190
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:742 → 871
    Focal_AT; Focal adhesion targeting region

  98. NM_001387631.1 → NP_001374560.1  focal adhesion kinase 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:420 → 689
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:924 → 1053
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  99. NM_001387632.1 → NP_001374561.1  focal adhesion kinase 1 isoform 59

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:895 → 1024
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  100. NM_001387633.1 → NP_001374562.1  focal adhesion kinase 1 isoform 68

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:422 → 691
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:905 → 1034
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  101. NM_001387634.1 → NP_001374563.1  focal adhesion kinase 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:421 → 690
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:925 → 1054
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  102. NM_001387635.1 → NP_001374564.1  focal adhesion kinase 1 isoform 53

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:266 → 535
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 215
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:767 → 896
    Focal_AT; Focal adhesion targeting region

  103. NM_001387636.1 → NP_001374565.1  focal adhesion kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:916 → 1045
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  104. NM_001387637.1 → NP_001374566.1  focal adhesion kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
    UniProtKB/TrEMBL
    A0A059VC25
    Related
    ENSP00000378644.3, ENST00000395218.3
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:916 → 1045
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  105. NM_001387638.1 → NP_001374567.1  focal adhesion kinase 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:919 → 1048
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  106. NM_001387639.1 → NP_001374568.1  focal adhesion kinase 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:428 → 697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:932 → 1061
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  107. NM_001387640.1 → NP_001374569.1  focal adhesion kinase 1 isoform 64

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:456 → 725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:939 → 1068
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  108. NM_001387641.1 → NP_001374570.1  focal adhesion kinase 1 isoform 72

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:428 → 697
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:49 → 271
    B41; Band 4.1 homologues
    cd13190
    Location:267 → 377
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:929 → 1058
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:48 → 143
    FERM_N_2; FERM N-terminal domain

  109. NM_001387642.1 → NP_001374571.1  focal adhesion kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:916 → 1045
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  110. NM_001387643.1 → NP_001374572.1  focal adhesion kinase 1 isoform 65

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS94347.1
    UniProtKB/TrEMBL
    A0A059VC25, E7ESA6
    Conserved Domains (5) summary
    cd05056
    Location:459 → 728
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:960 → 1089
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:79 → 174
    FERM_N_2; FERM N-terminal domain

  111. NM_001387644.1 → NP_001374573.1  focal adhesion kinase 1 isoform 62

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:462 → 731
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:49 → 271
    B41; Band 4.1 homologues
    cd13190
    Location:267 → 377
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:966 → 1095
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:48 → 143
    FERM_N_2; FERM N-terminal domain

  112. NM_001387645.1 → NP_001374574.1  focal adhesion kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:916 → 1045
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  113. NM_001387646.1 → NP_001374575.1  focal adhesion kinase 1 isoform 65

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS94347.1
    UniProtKB/TrEMBL
    A0A059VC25, E7ESA6
    Conserved Domains (5) summary
    cd05056
    Location:459 → 728
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:960 → 1089
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:79 → 174
    FERM_N_2; FERM N-terminal domain

  114. NM_001387647.1 → NP_001374576.1  focal adhesion kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:916 → 1045
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  115. NM_001387648.1 → NP_001374577.1  focal adhesion kinase 1 isoform 65

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS94347.1
    UniProtKB/TrEMBL
    A0A059VC25, E7ESA6
    Conserved Domains (5) summary
    cd05056
    Location:459 → 728
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:960 → 1089
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:79 → 174
    FERM_N_2; FERM N-terminal domain

  116. NM_001387649.1 → NP_001374578.1  focal adhesion kinase 1 isoform 63

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (3) summary
    cd05056
    Location:472 → 741
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

  117. NM_001387650.1 → NP_001374579.1  focal adhesion kinase 1 isoform 65

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS94347.1
    UniProtKB/TrEMBL
    A0A059VC25, E7ESA6
    Conserved Domains (5) summary
    cd05056
    Location:459 → 728
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:960 → 1089
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:79 → 174
    FERM_N_2; FERM N-terminal domain

  118. NM_001387651.1 → NP_001374580.1  focal adhesion kinase 1 isoform 69

    Status: REVIEWED

    Source sequence(s)
    AC100860, AC105009
    Consensus CDS
    CCDS94345.1
    UniProtKB/TrEMBL
    E5RFW9, E5RI72
    Related
    ENSP00000427904.1, ENST00000520892.5
    Conserved Domains (1) summary
    pfam18038
    Location:35 → 121
    FERM_N_2; FERM N-terminal domain

  119. NM_001387652.1 → NP_001374581.1  focal adhesion kinase 1 isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:302 → 571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:803 → 932
    Focal_AT; Focal adhesion targeting region

  120. NM_001387653.1 → NP_001374582.1  focal adhesion kinase 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:379 → 648
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 328
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:880 → 1009
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  121. NM_001387654.1 → NP_001374583.1  focal adhesion kinase 1 isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    Q59GN8
    Conserved Domains (4) summary
    cd05056
    Location:302 → 571
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:9 → 145
    B41; Band 4.1 homologues
    cd13190
    Location:141 → 251
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:803 → 932
    Focal_AT; Focal adhesion targeting region

  122. NM_001387655.1 → NP_001374584.1  focal adhesion kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:916 → 1045
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  123. NM_001387656.1 → NP_001374585.1  focal adhesion kinase 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:898 → 1027
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  124. NM_001387657.1 → NP_001374586.1  focal adhesion kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:916 → 1045
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  125. NM_001387658.1 → NP_001374587.1  focal adhesion kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:916 → 1045
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  126. NM_001387659.1 → NP_001374588.1  focal adhesion kinase 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:919 → 1048
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

  127. NM_001387660.1 → NP_001374589.1  focal adhesion kinase 1 isoform 65

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS94347.1
    UniProtKB/TrEMBL
    A0A059VC25, E7ESA6
    Related
    ENSP00000429082.1, ENST00000517887.5
    Conserved Domains (5) summary
    cd05056
    Location:459 → 728
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:960 → 1089
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:79 → 174
    FERM_N_2; FERM N-terminal domain

  128. NM_001387661.1 → NP_001374590.1  focal adhesion kinase 1 isoform 65

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Consensus CDS
    CCDS94347.1
    UniProtKB/TrEMBL
    A0A059VC25, E7ESA6
    Conserved Domains (5) summary
    cd05056
    Location:459 → 728
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:960 → 1089
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:79 → 174
    FERM_N_2; FERM N-terminal domain

  129. NM_001387662.1 → NP_001374591.1  focal adhesion kinase 1 isoform 61

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (5) summary
    cd05056
    Location:459 → 728
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:963 → 1092
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:79 → 174
    FERM_N_2; FERM N-terminal domain

  130. NM_005607.5 → NP_005598.3  focal adhesion kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_005598.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes isoform b.
    Source sequence(s)
    AB209083, AC067931, AC100860, AL832961, BF434494, DA236314
    UniProtKB/TrEMBL
    A0A059VC25, Q658W2
    Conserved Domains (6) summary
    cd05056
    Location:437 → 706
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:58 → 280
    B41; Band 4.1 homologues
    cd13190
    Location:276 → 386
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:165 → 270
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:938 → 1067
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:444 → 698
    Pkinase_Tyr; Protein tyrosine kinase

  131. NM_153831.4 → NP_722560.1  focal adhesion kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_722560.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1 and 5 both encode the same isoform (a).
    Source sequence(s)
    AB209083, AC067931, AL832961, BF434494, DA236314, L13616
    Consensus CDS
    CCDS6381.1
    UniProtKB/Swiss-Prot
    B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
    UniProtKB/TrEMBL
    A0A059VC25
    Related
    ENSP00000429911.1, ENST00000522684.5
    Conserved Domains (5) summary
    cd05056
    Location:415 → 684
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:916 → 1045
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:35 → 130
    FERM_N_2; FERM N-terminal domain

RNA

  1. NR_148036.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235

  2. NR_148037.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235

  3. NR_148038.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235

  4. NR_148039.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235

  5. NR_170670.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC100860

  6. NR_170671.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235
    Related
    ENST00000519993.5

  7. NR_170672.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235

  8. NR_170673.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC067931, AC100860, AC105009, AC105235

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    140657900..141002079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422049.1 → XP_047278005.1  focal adhesion kinase 1 isoform X24

    UniProtKB/TrEMBL
    A0A8Q3WLM4

  2. XM_047422021.1 → XP_047277977.1  focal adhesion kinase 1 isoform X4

  3. XM_047422054.1 → XP_047278010.1  focal adhesion kinase 1 isoform X38

  4. XM_047422052.1 → XP_047278008.1  focal adhesion kinase 1 isoform X37

  5. XM_047422050.1 → XP_047278006.1  focal adhesion kinase 1 isoform X36

  6. XM_047422039.1 → XP_047277995.1  focal adhesion kinase 1 isoform X24

    UniProtKB/TrEMBL
    A0A8Q3WLM4

  7. XM_047422045.1 → XP_047278001.1  focal adhesion kinase 1 isoform X32

  8. XM_024447209.2 → XP_024302977.1  focal adhesion kinase 1 isoform X30

    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:437 → 706
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87 → 309
    B41; Band 4.1 homologues
    cd13190
    Location:305 → 379
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:941 → 1070
    Focal_AT; Focal adhesion targeting region

  9. XM_047422046.1 → XP_047278002.1  focal adhesion kinase 1 isoform X33

  10. XM_024447208.2 → XP_024302976.1  focal adhesion kinase 1 isoform X28

    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:443 → 712
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87 → 309
    B41; Band 4.1 homologues
    cd13190
    Location:305 → 379
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:947 → 1076
    Focal_AT; Focal adhesion targeting region

  11. XM_047422032.1 → XP_047277988.1  focal adhesion kinase 1 isoform X15

  12. XM_047422043.1 → XP_047277999.1  focal adhesion kinase 1 isoform X29

  13. XM_024447207.2 → XP_024302975.1  focal adhesion kinase 1 isoform X27

    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:466 → 735
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87 → 309
    B41; Band 4.1 homologues
    cd13190
    Location:305 → 415
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:949 → 1078
    Focal_AT; Focal adhesion targeting region

  14. XM_047422035.1 → XP_047277991.1  focal adhesion kinase 1 isoform X20

  15. XM_047422033.1 → XP_047277989.1  focal adhesion kinase 1 isoform X18

  16. XM_047422040.1 → XP_047277996.1  focal adhesion kinase 1 isoform X25

  17. XM_024447202.2 → XP_024302970.1  focal adhesion kinase 1 isoform X16

    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:473 → 742
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87 → 309
    B41; Band 4.1 homologues
    cd13190
    Location:305 → 415
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:974 → 1103
    Focal_AT; Focal adhesion targeting region

  18. XM_047422029.1 → XP_047277985.1  focal adhesion kinase 1 isoform X12

  19. XM_047422041.1 → XP_047277997.1  focal adhesion kinase 1 isoform X26

  20. XM_024447203.2 → XP_024302971.1  focal adhesion kinase 1 isoform X17

    UniProtKB/TrEMBL
    A0A059VC25
    Conserved Domains (4) summary
    cd05056
    Location:472 → 741
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:87 → 309
    B41; Band 4.1 homologues
    cd13190
    Location:305 → 415
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:973 → 1102
    Focal_AT; Focal adhesion targeting region

  21. XM_047422030.1 → XP_047277986.1  focal adhesion kinase 1 isoform X13

  22. XM_047422038.1 → XP_047277994.1  focal adhesion kinase 1 isoform X23

  23. XM_047422026.1 → XP_047277982.1  focal adhesion kinase 1 isoform X9

  24. XM_047422025.1 → XP_047277981.1  focal adhesion kinase 1 isoform X8

  25. XM_047422027.1 → XP_047277983.1  focal adhesion kinase 1 isoform X10

  26. XM_047422022.1 → XP_047277978.1  focal adhesion kinase 1 isoform X5

  27. XM_047422018.1 → XP_047277974.1  focal adhesion kinase 1 isoform X3

  28. XM_047422024.1 → XP_047277980.1  focal adhesion kinase 1 isoform X7

  29. XM_047422023.1 → XP_047277979.1  focal adhesion kinase 1 isoform X6

  30. XM_047422017.1 → XP_047277973.1  focal adhesion kinase 1 isoform X2

  31. XM_047422016.1 → XP_047277972.1  focal adhesion kinase 1 isoform X1

  32. XM_047422047.1 → XP_047278003.1  focal adhesion kinase 1 isoform X34

  33. XM_047422037.1 → XP_047277993.1  focal adhesion kinase 1 isoform X22

  34. XM_047422036.1 → XP_047277992.1  focal adhesion kinase 1 isoform X21

  35. XM_047422034.1 → XP_047277990.1  focal adhesion kinase 1 isoform X19

  36. XM_047422031.1 → XP_047277987.1  focal adhesion kinase 1 isoform X14

  37. XM_047422028.1 → XP_047277984.1  focal adhesion kinase 1 isoform X11

  38. XM_047422019.1 → XP_047277975.1  focal adhesion kinase 1 isoform X4

  39. XM_047422053.1 → XP_047278009.1  focal adhesion kinase 1 isoform X24

    UniProtKB/TrEMBL
    A0A8Q3WLM4

  40. XM_047422044.1 → XP_047278000.1  focal adhesion kinase 1 isoform X31

  41. XM_047422020.1 → XP_047277976.1  focal adhesion kinase 1 isoform X4

  42. XM_047422048.1 → XP_047278004.1  focal adhesion kinase 1 isoform X35

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    141777902..142122150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360920.1 → XP_054216895.1  focal adhesion kinase 1 isoform X24

    UniProtKB/TrEMBL
    A0A8Q3WLM4

  2. XM_054360924.1 → XP_054216899.1  focal adhesion kinase 1 isoform X38

  3. XM_054360922.1 → XP_054216897.1  focal adhesion kinase 1 isoform X37

  4. XM_054360921.1 → XP_054216896.1  focal adhesion kinase 1 isoform X36

  5. XM_054360908.1 → XP_054216883.1  focal adhesion kinase 1 isoform X24

    UniProtKB/TrEMBL
    A0A8Q3WLM4

  6. XM_054360916.1 → XP_054216891.1  focal adhesion kinase 1 isoform X32

  7. XM_054360914.1 → XP_054216889.1  focal adhesion kinase 1 isoform X30

  8. XM_054360917.1 → XP_054216892.1  focal adhesion kinase 1 isoform X33

  9. XM_054360912.1 → XP_054216887.1  focal adhesion kinase 1 isoform X28

  10. XM_054360898.1 → XP_054216873.1  focal adhesion kinase 1 isoform X15

  11. XM_054360913.1 → XP_054216888.1  focal adhesion kinase 1 isoform X29

  12. XM_054360911.1 → XP_054216886.1  focal adhesion kinase 1 isoform X27

  13. XM_054360903.1 → XP_054216878.1  focal adhesion kinase 1 isoform X20

  14. XM_054360901.1 → XP_054216876.1  focal adhesion kinase 1 isoform X18

  15. XM_054360909.1 → XP_054216884.1  focal adhesion kinase 1 isoform X25

  16. XM_054360899.1 → XP_054216874.1  focal adhesion kinase 1 isoform X16

  17. XM_054360895.1 → XP_054216870.1  focal adhesion kinase 1 isoform X12

  18. XM_054360910.1 → XP_054216885.1  focal adhesion kinase 1 isoform X26

  19. XM_054360900.1 → XP_054216875.1  focal adhesion kinase 1 isoform X17

  20. XM_054360896.1 → XP_054216871.1  focal adhesion kinase 1 isoform X13

  21. XM_054360906.1 → XP_054216881.1  focal adhesion kinase 1 isoform X23

  22. XM_054360892.1 → XP_054216867.1  focal adhesion kinase 1 isoform X9

  23. XM_054360891.1 → XP_054216866.1  focal adhesion kinase 1 isoform X8

  24. XM_054360893.1 → XP_054216868.1  focal adhesion kinase 1 isoform X10

  25. XM_054360888.1 → XP_054216863.1  focal adhesion kinase 1 isoform X5

  26. XM_054360885.1 → XP_054216860.1  focal adhesion kinase 1 isoform X3

  27. XM_054360890.1 → XP_054216865.1  focal adhesion kinase 1 isoform X7

  28. XM_054360889.1 → XP_054216864.1  focal adhesion kinase 1 isoform X6

  29. XM_054360884.1 → XP_054216859.1  focal adhesion kinase 1 isoform X2

  30. XM_054360883.1 → XP_054216858.1  focal adhesion kinase 1 isoform X1

  31. XM_054360918.1 → XP_054216893.1  focal adhesion kinase 1 isoform X34

  32. XM_054360905.1 → XP_054216880.1  focal adhesion kinase 1 isoform X22

  33. XM_054360904.1 → XP_054216879.1  focal adhesion kinase 1 isoform X21

  34. XM_054360902.1 → XP_054216877.1  focal adhesion kinase 1 isoform X19

  35. XM_054360897.1 → XP_054216872.1  focal adhesion kinase 1 isoform X14

  36. XM_054360894.1 → XP_054216869.1  focal adhesion kinase 1 isoform X11

  37. XM_054360886.1 → XP_054216861.1  focal adhesion kinase 1 isoform X4

  38. XM_054360923.1 → XP_054216898.1  focal adhesion kinase 1 isoform X24

    UniProtKB/TrEMBL
    A0A8Q3WLM4

  39. XM_054360915.1 → XP_054216890.1  focal adhesion kinase 1 isoform X31

  40. XM_054360887.1 → XP_054216862.1  focal adhesion kinase 1 isoform X4

  41. XM_054360907.1 → XP_054216882.1  focal adhesion kinase 1 isoform X24

    UniProtKB/TrEMBL
    A0A8Q3WLM4

  42. XM_054360919.1 → XP_054216894.1  focal adhesion kinase 1 isoform X35

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05397.2 GenPept UniProtKB/Swiss-Prot:Q05397

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