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PTK6 protein tyrosine kinase 6 [ Homo sapiens (human) ]

Gene ID: 5753, updated on 4-Jan-2025

Summary

Official Symbol
PTK6provided by HGNC
Official Full Name
protein tyrosine kinase 6provided by HGNC
Primary source
HGNC:HGNC:9617
See related
Ensembl:ENSG00000101213 MIM:602004; AllianceGenome:HGNC:9617
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRK
Summary
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression
Biased expression in esophagus (RPKM 27.3), skin (RPKM 21.0) and 9 other tissues See more
Orthologs
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Genomic context

See PTK6 in Genome Data Viewer
Location:
20q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (63528001..63537376, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65340691..65349973, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62159354..62168729, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62149497-62150374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62150375-62151251 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62151252-62152128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13157 Neighboring gene pancreatic progenitor cell differentiation and proliferation factor Neighboring gene Sharpr-MPRA regulatory region 4884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13159 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13160 Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18227 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62175449-62176002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62178175-62178816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18228 Neighboring gene Sharpr-MPRA regulatory region 13995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13164 Neighboring gene fibronectin type III domain containing 11

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ42088

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding  
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables identical protein binding PubMed 
enables non-membrane spanning protein tyrosine kinase activity  
enables non-membrane spanning protein tyrosine kinase activity PubMed 
enables protein binding PubMed 
enables protein tyrosine kinase activity PubMed 
enables protein tyrosine kinase activity  
enables signaling receptor binding  
Process Evidence Code Pubs
involved_in ERBB2 signaling pathway  
involved_in cell differentiation  
involved_in cell migration PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
involved_in cellular response to retinoic acid PubMed 
involved_in chromatin remodeling  
involved_in intestinal epithelial cell differentiation  
involved_in negative regulation of growth  
involved_in negative regulation of protein tyrosine kinase activity PubMed 
involved_in positive regulation of DNA replication  
involved_in positive regulation of cell cycle  
involved_in positive regulation of epidermal growth factor receptor signaling pathway  
involved_in positive regulation of neuron projection development PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT  
involved_in protein autophosphorylation PubMed 
involved_in protein phosphorylation PubMed 
involved_in tyrosine phosphorylation of STAT protein PubMed 
Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
located_in nuclear body  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus PubMed 
is_active_in plasma membrane  
located_in plasma membrane  
located_in ruffle PubMed 

General protein information

Preferred Names
protein-tyrosine kinase 6
Names
PTK6 protein tyrosine kinase 6
breast tumor kinase
protein-tyrosine kinase BRK
tyrosine-protein kinase BRK
NP_001243287.1
NP_005966.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256358.2NP_001243287.1  protein-tyrosine kinase 6 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region which results in a frameshift and early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1. This variant is also known as lambdaM5 and Alt-PTK6.
    Source sequence(s)
    AK301364, AL121829, X78549
    Consensus CDS
    CCDS74750.1
    UniProtKB/Swiss-Prot
    Q13882
    Related
    ENSP00000217185.3, ENST00000217185.3
    Conserved Domains (1) summary
    cd11847
    Location:1269
    SH3_Brk; Src homology 3 domain of Brk (Breast tumor kinase) Protein Tyrosine Kinase (PTK), also called PTK6
  2. NM_005975.4NP_005966.1  protein-tyrosine kinase 6 isoform 1

    See identical proteins and their annotated locations for NP_005966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AL121829, BC035843, DA762278, X78549
    Consensus CDS
    CCDS13524.1
    UniProtKB/Swiss-Prot
    B2RCR3, B4DW46, Q13882, Q58F01
    Related
    ENSP00000442460.2, ENST00000542869.3
    Conserved Domains (4) summary
    cd05148
    Location:184444
    PTKc_Srm_Brk; Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (Srm) and Breast tumor kinase (Brk)
    cd10358
    Location:75174
    SH2_PTK6_Brk; Src homology 2 domain found in protein-tyrosine kinase-6 (PTK6) which is also known as breast tumor kinase (Brk)
    cd11847
    Location:1269
    SH3_Brk; Src homology 3 domain of Brk (Breast tumor kinase) Protein Tyrosine Kinase (PTK), also called PTK6
    smart00221
    Location:192441
    STYKc; Protein kinase; unclassified specificity

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    63528001..63537376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    65340691..65349973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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