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DENND1A DENN domain containing 1A [ Homo sapiens (human) ]

Gene ID: 57706, updated on 3-Apr-2024

Summary

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Official Symbol
DENND1Aprovided by HGNC
Official Full Name
DENN domain containing 1Aprovided by HGNC
Primary source
HGNC:HGNC:29324
See related
Ensembl:ENSG00000119522 MIM:613633; AllianceGenome:HGNC:29324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM31A; KIAA1608
Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in spleen (RPKM 4.6), kidney (RPKM 4.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
9q33.3
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (123379658..123930126, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (135577391..136128012, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (126141937..126692405, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28935 Neighboring gene uncharacterized LOC105376265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126088537-126089038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126089039-126089538 Neighboring gene uncharacterized LOC124902266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28939 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126111505-126112006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126112007-126112506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126116439-126116938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126120157-126120824 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126124971-126125833 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126128307-126128870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126130279-126130928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126138602-126139219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126137983-126138601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126141215-126141716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126141717-126142216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28941 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:126149353-126149548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126160204-126160704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126164885-126165506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126181680-126182180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126182181-126182681 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126185399-126186000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28942 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:126188501-126188713 Neighboring gene crumbs cell polarity complex component 2 Neighboring gene microRNA 601 Neighboring gene Sharpr-MPRA regulatory region 10302 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126244597-126245462 Neighboring gene microRNA 7150 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:126323227-126323788 Neighboring gene uncharacterized LOC105376266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126417147-126417647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28947 Neighboring gene Sharpr-MPRA regulatory region 1336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28950 Neighboring gene VISTA enhancer hs314 Neighboring gene uncharacterized LOC124902336 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:126625148-126625690 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:126625691-126626232 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:126656962-126657562 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class F pseudogene 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:126665592-126666092 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:126666093-126666593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126691277-126691962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126770394-126771104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126769682-126770393 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:126767105-126767862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126763235-126763735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126760357-126761111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28956 Neighboring gene uncharacterized LOC105376267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126755411-126755911 Neighboring gene LHX2 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Multi-center Genome-wide Association Study of Cervical Dystonia. Sun YV, et al. Mov Disord, 2021 Dec. PMID 34320236, Free PMC Article
  2. Association analysis between the tag single nucleotide polymorphisms of DENND1A and the risk of polycystic ovary syndrome in Chinese Han women. Zhu YN, et al. BMC Med Genet, 2020 Jan 15. PMID 31941453, Free PMC Article
  3. Differential association of DENND1A genetic variants with polycystic ovary syndrome in Tunisian but not Bahraini Arab women. Dallel M, et al. Gene, 2018 Mar 20. PMID 29325736
  4. The association of DENND1A gene polymorphisms and polycystic ovary syndrome risk: a systematic review and meta-analysis. Gao J, et al. Arch Gynecol Obstet, 2016 Nov. PMID 27488699
  5. Alternative splicing of DENND1A, a PCOS candidate gene, generates variant 2. Tee MK, et al. Mol Cell Endocrinol, 2016 Oct 15. PMID 27297658, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of FSHR and DENND1A polymorphisms with polycystic ovary syndrome: a meta-analysis.
    Title: Association of FSHR and DENND1A polymorphisms with polycystic ovary syndrome: a meta-analysis.
  2. A Multi-center Genome-wide Association Study of Cervical Dystonia.
    Title: A Multi-center Genome-wide Association Study of Cervical Dystonia.
  3. The tagging SNPs rs2479106 and rs2468819 in the DENND1A gene are associated with polycystic ovary syndrome (PCOS) in the Chinese population, whereas rs2670139, rs2536951 and rs2479102 are not correlated with PCOS in the same population
    Title: Association analysis between the tag single nucleotide polymorphisms of DENND1A and the risk of polycystic ovary syndrome in Chinese Han women.
  4. Genetic variants of PCOS (rs13405728 in LHCGR gene; rs13429458 in THADA gene and rs2479106 in DENND1A gene) may not be involved in the development of preeclampsia in Han Chinese women.
    Title: Association study between variants in LHCGR DENND1A and THADA with preeclampsia risk in Han Chinese populations.
  5. decreased miR-130b-3p expression in PCOS theca cells, which was correlated with increased DENND1A.V2, cytochrome P450 17alpha-hydroxylase (CYP17A1) mRNA and androgen biosynthesis.
    Title: miRNA Profiling Reveals miRNA-130b-3p Mediates DENND1A Variant 2 Expression and Androgen Biosynthesis.
  6. we evaluated the frequencies of CYP19A1 rs2414096 and DENND1A rs10818854 polymorphisms in overweight and normal individuals and didn't find any significant difference between these groups which demonstrates a lack of association between obesity risk and these SNPs
    Title: The role of DENND1A and CYP19A1 gene variants in individual susceptibility to obesity in Turkish population-a preliminary study.
  7. The association of DENND1A rs10818854 and rs10986105 variants with PCOS in Tunisian but not Bahraini women confirms the dependence of this association on the ethnic/racial origin of study subjects.
    Title: Differential association of DENND1A genetic variants with polycystic ovary syndrome in Tunisian but not Bahraini Arab women.
  8. Genome-wide association studies have identified DENND1A as a candidate gene for polycystic ovary syndrome (PCOS). PCOS theca cells are shown to overexpress DENND1A splice variant 2 (V2), but not V1. Also, the genetic variation 330 bp upstream of exon 20A is not associated with VE variant expression.
    Title: Alternative splicing of DENND1A, a PCOS candidate gene, generates variant 2.
  9. DENND1A gene variant is likely to have influence on PCOS risk.
    Title: The association of DENND1A gene polymorphisms and polycystic ovary syndrome risk: a systematic review and meta-analysis.
  10. This meta-analysis suggested that rs2479106 and rs10818854 polymorphisms in the DENND1A gene were associated with increased risk of polycystic ovary syndrome
    Title: Association of DENND1A Gene Polymorphisms with Polycystic Ovary Syndrome: A Meta-Analysis.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
EBI GWAS Catalog
A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.
EBI GWAS Catalog
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
EBI GWAS Catalog
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
EBI GWAS Catalog
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
EBI GWAS Catalog
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
EBI GWAS Catalog
Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38464

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Rab protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 1A
Names
DENN/MADD domain containing 1A
connecdenn 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001352964.2 → NP_001339893.1  DENN domain-containing protein 1A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC006450, AL161790, AL390774, AL445489
    Consensus CDS
    CCDS94479.1
    UniProtKB/TrEMBL
    A0A0A0MS48
    Related
    ENSP00000377763.4, ENST00000394215.7
    Conserved Domains (4) summary
    smart00801
    Location:305 → 371
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:95 → 273
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 91
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cl26464
    Location:705 → 1056
    Atrophin-1; Atrophin-1 family

  2. NM_001352965.2 → NP_001339894.1  DENN domain-containing protein 1A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC006450, AL161790, AL390774, AL445489
    UniProtKB/TrEMBL
    Q9HCG4
    Conserved Domains (4) summary
    smart00801
    Location:273 → 339
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:63 → 241
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:10 → 59
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cl26464
    Location:655 → 1006
    Atrophin-1; Atrophin-1 family

  3. NM_001352966.2 → NP_001339895.1  DENN domain-containing protein 1A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC006450, AL161790, AL390774, AL445489
    Conserved Domains (3) summary
    smart00801
    Location:275 → 341
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:65 → 243
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:14 → 61
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  4. NM_001352967.2 → NP_001339896.1  DENN domain-containing protein 1A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC006450, AL161790, AL390774, AL445489
    Conserved Domains (3) summary
    smart00801
    Location:273 → 339
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:63 → 241
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:26 → 59
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  5. NM_001352968.2 → NP_001339897.1  DENN domain-containing protein 1A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC006450, AL161790, AL390774, AL445489
    Consensus CDS
    CCDS87687.1
    Related
    ENSP00000362720.1, ENST00000373618.1
    Conserved Domains (3) summary
    smart00801
    Location:273 → 339
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:63 → 241
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:26 → 59
    uDENN; uDENN domain

  6. NM_001393654.1 → NP_001380583.1  DENN domain-containing protein 1A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC006450, AL161790, AL390774, AL445489
    UniProtKB/TrEMBL
    Q9HCG4
    Conserved Domains (4) summary
    smart00801
    Location:305 → 371
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:95 → 273
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 91
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:687 → 1038
    PHA03247; large tegument protein UL36; Provisional

  7. NM_001400446.1 → NP_001387375.1  DENN domain-containing protein 1A isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC006450, AL161790, AL390774, AL445489

  8. NM_001400449.1 → NP_001387378.1  DENN domain-containing protein 1A isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC006450, AL161790, AL390774, AL445489

  9. NM_020946.2 → NP_065997.1  DENN domain-containing protein 1A isoform 1

    See identical proteins and their annotated locations for NP_065997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC006450, AL161790, AL390774, AL445489
    Consensus CDS
    CCDS35133.1
    UniProtKB/Swiss-Prot
    A8MZA3, B1AM80, B7Z3C8, B7Z669, D3PFD3, Q05C88, Q5VWF0, Q6PJZ5, Q8IVD6, Q8TEH3, Q9H796
    UniProtKB/TrEMBL
    Q9HCG4
    Related
    ENSP00000362727.2, ENST00000373624.6
    Conserved Domains (3) summary
    smart00801
    Location:305 → 371
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:95 → 273
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 91
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  10. NM_024820.3 → NP_079096.2  DENN domain-containing protein 1A isoform 2

    See identical proteins and their annotated locations for NP_079096.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1, that causes a frameshift. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL445489, BC009616, BC028061, BC039703
    Consensus CDS
    CCDS35134.1
    UniProtKB/Swiss-Prot
    Q8TEH3
    Related
    ENSP00000362722.3, ENST00000373620.7
    Conserved Domains (3) summary
    smart00801
    Location:305 → 371
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:95 → 273
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 91
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

RNA

  1. NR_148208.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006450, AL161790, AL390774, AL445489

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    123379658..123930126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423624.1 → XP_047279580.1  DENN domain-containing protein 1A isoform X18

  2. XM_047423622.1 → XP_047279578.1  DENN domain-containing protein 1A isoform X16

  3. XM_024447622.2 → XP_024303390.1  DENN domain-containing protein 1A isoform X9

    UniProtKB/TrEMBL
    Q9HCG4
    Conserved Domains (4) summary
    smart00801
    Location:275 → 341
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:65 → 243
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:14 → 61
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cl26464
    Location:675 → 1026
    Atrophin-1; Atrophin-1 family

  4. XM_047423625.1 → XP_047279581.1  DENN domain-containing protein 1A isoform X19

  5. XM_047423623.1 → XP_047279579.1  DENN domain-containing protein 1A isoform X17

  6. XM_024447621.2 → XP_024303389.1  DENN domain-containing protein 1A isoform X10

    UniProtKB/TrEMBL
    Q9HCG4
    Conserved Domains (4) summary
    smart00801
    Location:273 → 339
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:63 → 241
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:26 → 59
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cl26464
    Location:673 → 1024
    Atrophin-1; Atrophin-1 family

  7. XM_047423621.1 → XP_047279577.1  DENN domain-containing protein 1A isoform X15

  8. XM_047423618.1 → XP_047279574.1  DENN domain-containing protein 1A isoform X11

  9. XM_011518882.4 → XP_011517184.1  DENN domain-containing protein 1A isoform X2

    Conserved Domains (3) summary
    smart00801
    Location:320 → 386
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:110 → 288
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:24 → 106
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  10. XM_006717195.5 → XP_006717258.1  DENN domain-containing protein 1A isoform X5

    Conserved Domains (3) summary
    smart00801
    Location:320 → 386
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:110 → 288
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:24 → 106
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  11. XM_011518886.4 → XP_011517188.1  DENN domain-containing protein 1A isoform X8

    Conserved Domains (3) summary
    smart00801
    Location:320 → 386
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:110 → 288
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:24 → 106
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  12. XM_005252111.5 → XP_005252168.1  DENN domain-containing protein 1A isoform X13

    Conserved Domains (3) summary
    smart00801
    Location:320 → 386
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:110 → 288
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:24 → 106
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  13. XM_011518885.4 → XP_011517187.1  DENN domain-containing protein 1A isoform X6

    UniProtKB/TrEMBL
    Q9HCG4
    Related
    ENST00000473039.5
    Conserved Domains (3) summary
    smart00801
    Location:284 → 350
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:74 → 252
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 70
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  14. XM_047423615.1 → XP_047279571.1  DENN domain-containing protein 1A isoform X4

  15. XM_047423613.1 → XP_047279569.1  DENN domain-containing protein 1A isoform X1

  16. XM_047423620.1 → XP_047279576.1  DENN domain-containing protein 1A isoform X14

  17. XM_047423614.1 → XP_047279570.1  DENN domain-containing protein 1A isoform X3

  18. XM_047423616.1 → XP_047279572.1  DENN domain-containing protein 1A isoform X7

  19. XM_047423619.1 → XP_047279575.1  DENN domain-containing protein 1A isoform X12

  20. XM_024447623.2 → XP_024303391.1  DENN domain-containing protein 1A isoform X20

    UniProtKB/TrEMBL
    Q9HCG4
    Conserved Domains (3) summary
    smart00801
    Location:109 → 175
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:4 → 77
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl26464
    Location:509 → 860
    Atrophin-1; Atrophin-1 family

  21. XM_047423630.1 → XP_047279586.1  DENN domain-containing protein 1A isoform X26

  22. XM_047423631.1 → XP_047279587.1  DENN domain-containing protein 1A isoform X27

  23. XM_047423627.1 → XP_047279583.1  DENN domain-containing protein 1A isoform X22

  24. XM_005252113.6 → XP_005252170.1  DENN domain-containing protein 1A isoform X24

    Conserved Domains (3) summary
    smart00801
    Location:320 → 386
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:110 → 288
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:24 → 106
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  25. XM_047423626.1 → XP_047279582.1  DENN domain-containing protein 1A isoform X21

  26. XM_047423629.1 → XP_047279585.1  DENN domain-containing protein 1A isoform X25

  27. XM_047423628.1 → XP_047279584.1  DENN domain-containing protein 1A isoform X23

  28. XM_047423633.1 → XP_047279589.1  DENN domain-containing protein 1A isoform X29

  29. XM_047423632.1 → XP_047279588.1  DENN domain-containing protein 1A isoform X28

RNA

  1. XR_007061334.1 RNA Sequence

  2. XR_007061335.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    135577391..136128012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363366.1 → XP_054219341.1  DENN domain-containing protein 1A isoform X18

  2. XM_054363364.1 → XP_054219339.1  DENN domain-containing protein 1A isoform X16

  3. XM_054363357.1 → XP_054219332.1  DENN domain-containing protein 1A isoform X9

  4. XM_054363367.1 → XP_054219342.1  DENN domain-containing protein 1A isoform X19

  5. XM_054363365.1 → XP_054219340.1  DENN domain-containing protein 1A isoform X17

  6. XM_054363358.1 → XP_054219333.1  DENN domain-containing protein 1A isoform X10

  7. XM_054363363.1 → XP_054219338.1  DENN domain-containing protein 1A isoform X15

  8. XM_054363359.1 → XP_054219334.1  DENN domain-containing protein 1A isoform X11

  9. XM_054363350.1 → XP_054219325.1  DENN domain-containing protein 1A isoform X2

  10. XM_054363353.1 → XP_054219328.1  DENN domain-containing protein 1A isoform X5

  11. XM_054363356.1 → XP_054219331.1  DENN domain-containing protein 1A isoform X8

  12. XM_054363361.1 → XP_054219336.1  DENN domain-containing protein 1A isoform X13

  13. XM_054363354.1 → XP_054219329.1  DENN domain-containing protein 1A isoform X6

  14. XM_054363352.1 → XP_054219327.1  DENN domain-containing protein 1A isoform X4

  15. XM_054363349.1 → XP_054219324.1  DENN domain-containing protein 1A isoform X1

  16. XM_054363362.1 → XP_054219337.1  DENN domain-containing protein 1A isoform X14

  17. XM_054363351.1 → XP_054219326.1  DENN domain-containing protein 1A isoform X3

  18. XM_054363355.1 → XP_054219330.1  DENN domain-containing protein 1A isoform X7

  19. XM_054363360.1 → XP_054219335.1  DENN domain-containing protein 1A isoform X12

  20. XM_054363372.1 → XP_054219347.1  DENN domain-containing protein 1A isoform X26

  21. XM_054363373.1 → XP_054219348.1  DENN domain-containing protein 1A isoform X27

  22. XM_054363368.1 → XP_054219343.1  DENN domain-containing protein 1A isoform X22

  23. XM_054363370.1 → XP_054219345.1  DENN domain-containing protein 1A isoform X24

  24. XM_054363371.1 → XP_054219346.1  DENN domain-containing protein 1A isoform X25

  25. XM_054363369.1 → XP_054219344.1  DENN domain-containing protein 1A isoform X23

  26. XM_054363375.1 → XP_054219350.1  DENN domain-containing protein 1A isoform X29

  27. XM_054363374.1 → XP_054219349.1  DENN domain-containing protein 1A isoform X28

RNA

  1. XR_008488053.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TEH3.2 GenPept UniProtKB/Swiss-Prot:Q8TEH3

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