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PTX3 pentraxin 3 [ Homo sapiens (human) ]

Gene ID: 5806, updated on 4-Jan-2025

Summary

Official Symbol
PTX3provided by HGNC
Official Full Name
pentraxin 3provided by HGNC
Primary source
HGNC:HGNC:9692
See related
Ensembl:ENSG00000163661 MIM:602492; AllianceGenome:HGNC:9692
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSG-14; TNFAIP5
Summary
This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]
Expression
Biased expression in bone marrow (RPKM 32.2), appendix (RPKM 24.8) and 6 other tissues See more
Orthologs
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Genomic context

See PTX3 in Genome Data Viewer
Location:
3q25.32
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (157436850..157443633)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (160211418..160218201)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (157154639..157161422)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928236 Neighboring gene uncharacterized LOC105374179 Neighboring gene VISTA enhancer hs2571 Neighboring gene NANOG hESC enhancer GRCh37_chr3:156973526-156974057 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:156992312-156992853 Neighboring gene PCBP2 pseudogene 4 Neighboring gene ventricular zone expressed PH domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:157216797-157217361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:157217362-157217925 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:157220998-157221232 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4666 Neighboring gene solute carrier family 66 member 1 like, pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_65660 Neighboring gene VISTA enhancer hs638 Neighboring gene RN7SK pseudogene 46

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables (1->3)-beta-D-glucan binding  
enables complement component C1q complex binding  
enables complement component C1q complex binding PubMed 
enables identical protein binding PubMed 
enables protein binding PubMed 
enables virion binding PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization  
involved_in inflammatory response PubMed 
involved_in innate immune response  
involved_in innate immune response PubMed 
involved_in negative regulation by host of viral exo-alpha-sialidase activity PubMed 
involved_in negative regulation by host of viral glycoprotein metabolic process PubMed 
involved_in negative regulation by host of viral process  
involved_in negative regulation of exo-alpha-sialidase activity PubMed 
involved_in negative regulation of glycoprotein metabolic process PubMed 
involved_in negative regulation of viral entry into host cell PubMed 
involved_in opsonization  
involved_in ovarian cumulus expansion  
involved_in positive regulation of nitric oxide biosynthetic process  
involved_in positive regulation of phagocytosis  
involved_in response to yeast  
Component Evidence Code Pubs
located_in extracellular matrix  
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in specific granule lumen  
located_in tertiary granule lumen  

General protein information

Preferred Names
pentraxin-related protein PTX3
Names
TNF alpha-induced protein 5
long pentraxin 3
tumor necrosis factor alpha-induced protein 5
tumor necrosis factor-inducible gene 14 protein
tumor necrosis factor-inducible protein TSG-14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051000.1 RefSeqGene

    Range
    5060..11843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002852.4NP_002843.2  pentraxin-related protein PTX3 precursor

    See identical proteins and their annotated locations for NP_002843.2

    Status: REVIEWED

    Source sequence(s)
    AC020630, BC039733, BQ010272, DA716533
    Consensus CDS
    CCDS3180.1
    UniProtKB/Swiss-Prot
    B2R6T6, P26022, Q38M82
    Related
    ENSP00000295927.3, ENST00000295927.4
    Conserved Domains (2) summary
    smart00159
    Location:175381
    PTX; Pentraxin / C-reactive protein / pentaxin family
    cl23844
    Location:81167
    Ble; Predicted trehalose synthase [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    157436850..157443633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    160211418..160218201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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