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Nkain4 Na+/K+ transporting ATPase interacting 4 [ Mus musculus (house mouse) ]

Gene ID: 58237, updated on 30-Apr-2024

Summary

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Official Symbol
Nkain4provided by MGI
Official Full Name
Na+/K+ transporting ATPase interacting 4provided by MGI
Primary source
MGI:MGI:1915372
See related
Ensembl:ENSMUSG00000027574 AllianceGenome:MGI:1915372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C030019F02Rik
Summary
Predicted to be involved in regulation of sodium ion transport. Located in membrane. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; respiratory system; and skeleton. Orthologous to human NKAIN4 (sodium/potassium transporting ATPase interacting 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 20.5), bladder adult (RPKM 14.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Nkain4 in Genome Data Viewer
Location:
2 H4; 2 103.53 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180576559..180596730, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180934766..180954937, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06743 Neighboring gene YTH N6-methyladenosine RNA binding protein 1 Neighboring gene baculoviral IAP repeat-containing 7 Neighboring gene STARR-seq mESC enhancer starr_06745 Neighboring gene ADP-ribosylation factor GTPase activating protein 1 Neighboring gene collagen, type XX, alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput trapping of secretory pathway genes in mouse embryonic stem cells. De-Zolt S, et al. Nucleic Acids Res, 2006 Feb 13. PMID 16478711, Free PMC Article
  2. Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold. Yang Y, et al. Hum Mol Genet, 2003 May 1. PMID 12700166
  3. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
  4. Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Inoue S, et al. Biochem Biophys Res Commun, 2000 Feb 16. PMID 10679242
  5. Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Heng X, et al. Elife, 2017 May 10. PMID 28489004, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC102050

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
Names
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001141933.1 → NP_001135405.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001135405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1, and encodes a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC061107, CK625327, EF058056
    Consensus CDS
    CCDS50841.1
    UniProtKB/Swiss-Prot
    Q9JMG4
    Related
    ENSMUSP00000104501.3, ENSMUST00000108873.9
    Conserved Domains (1) summary
    pfam05640
    Location:10 → 177
    NKAIN; Na,K-Atpase Interacting protein

  2. NM_021426.4 → NP_067401.3  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 1

    See identical proteins and their annotated locations for NP_067401.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
    Source sequence(s)
    BC061107, CK625327
    Consensus CDS
    CCDS17189.1
    UniProtKB/Swiss-Prot
    A2AWN3, A6MHQ2, A6MHQ3, Q5EBQ3, Q9D1V9, Q9D8W0, Q9JMG4
    Related
    ENSMUSP00000099342.4, ENSMUST00000103053.10
    Conserved Domains (1) summary
    pfam05640
    Location:10 → 206
    NKAIN; Na,K-Atpase Interacting protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180576559..180596730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319153.2 → XP_017174642.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

    UniProtKB/TrEMBL
    F7B7M8
    Related
    ENSMUSP00000116965.2, ENSMUST00000139929.8
    Conserved Domains (1) summary
    pfam05640
    Location:19 → 160
    NKAIN; Na,K-Atpase Interacting protein

  2. XM_030251916.2 → XP_030107776.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X6

    Conserved Domains (1) summary
    pfam05640
    Location:8 → 104
    NKAIN; Na,K-Atpase Interacting protein

  3. XM_006500690.5 → XP_006500753.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X4

    UniProtKB/TrEMBL
    F7B7M8
    Conserved Domains (1) summary
    pfam05640
    Location:8 → 133
    NKAIN; Na,K-Atpase Interacting protein

  4. XM_030251915.2 → XP_030107775.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X5

    UniProtKB/TrEMBL
    F7B7M8
    Conserved Domains (1) summary
    pfam05640
    Location:19 → 131
    NKAIN; Na,K-Atpase Interacting protein

  5. XM_030251914.2 → XP_030107774.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X2

    Conserved Domains (1) summary
    pfam05640
    Location:2 → 163
    NKAIN; Na,K-Atpase Interacting protein

  6. XM_006500689.5 → XP_006500752.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X1

    Conserved Domains (1) summary
    pfam05640
    Location:4 → 192
    NKAIN; Na,K-Atpase Interacting protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JMG4.1 GenPept UniProtKB/Swiss-Prot:Q9JMG4

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