Ppp1r1a protein phosphatase 1, regulatory (inhibitor) subunit 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp1r1aprovided by RGD
Official Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 1Aprovided by RGD
Primary source: RGD:62018
See related: Ensembl:ENSRNOG00000036827 AllianceGenome:RGD:62018
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. Located in cytoplasm and extracellular space. Orthologous to human PPP1R1A (protein phosphatase 1 regulatory inhibitor subunit 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 356.5), Kidney (RPKM 325.1) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (136533031..136540687, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (134654578..134662236, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (145146480..145154131, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein phosphatase inhibitor-1 augments a protein kinase A-dependent increase in the Ca2+ loading of the sarcoplasmic reticulum without changing its Ca2+ release.
Title: Protein phosphatase inhibitor-1 augments a protein kinase A-dependent increase in the Ca2+ loading of the sarcoplasmic reticulum without changing its Ca2+ release.
calcineurin and protein phosphatase-2A act to maintain a low basal level of phosphorylated (active) phosphatase inhibitor-1 in living cardiac myocytes
Title: Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127463 (e-PCR)
- UniSTS:210773

AA997855 (e-PCR)
- UniSTS:248426

RH130620 (e-PCR)
- UniSTS:213904

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycogen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 1A

Names: I-1; IPP-1; PP1 inhibitor 1; protein phosphatase inhibitor 1

NP_073167.1

EC 3.1.3.16

XP_006242499.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022676.3 → NP_073167.1 protein phosphatase 1 regulatory subunit 1A

See identical proteins and their annotated locations for NP_073167.1

Status: PROVISIONAL

Source sequence(s)

AY648296

UniProtKB/Swiss-Prot

P19103, Q6DSU5

UniProtKB/TrEMBL

A6KD15, A6KD17

Related

ENSRNOP00000052146.2, ENSRNOT00000055271.3

Conserved Domains (1) summary

pfam05395
Location:5 → 142

DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

136533031..136540687 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242437.5 → XP_006242499.1 protein phosphatase 1 regulatory subunit 1A isoform X1

UniProtKB/TrEMBL

A6KD15

Conserved Domains (1) summary

pfam05395
Location:5 → 141

DARPP-32; Protein phosphatase inhibitor 1/DARPP-32