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Ip6k2 inositol hexakisphosphate kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59268, updated on 2-May-2024

Summary

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Official Symbol
Ip6k2provided by RGD
Official Full Name
inositol hexakisphosphate kinase 2provided by RGD
Primary source
RGD:620529
See related
Ensembl:ENSRNOG00000020361 AllianceGenome:RGD:620529
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pius; Ihpk2
Summary
Predicted to enable flavonoid binding activity and inositol hexakisphosphate 5-kinase activity. Involved in phosphate ion transport. Predicted to be located in cell junction; fibrillar center; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human IP6K2 (inositol hexakisphosphate kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 179.7), Thymus (RPKM 158.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ip6k2 in Genome Data Viewer
Location:
8q32
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118362154..118388668)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109483843..109510172)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117574136..117599849)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094262 Neighboring gene solute carrier family 25 member 20 Neighboring gene uncharacterized LOC134480235 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit alpha Neighboring gene uncharacterized LOC134480236 Neighboring gene small nucleolar RNA SNORA28 Neighboring gene NCK interacting protein with SH3 domain Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 3 Neighboring gene solute carrier family 26 member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of intestinal Na+-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3. Katai K, et al. Biochem J, 1999 Nov 1. PMID 10527952, Free PMC Article
  2. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. Gu C, et al. J Med Chem, 2019 Feb 14. PMID 30624931, Free PMC Article
  3. Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells. Morrison BH, et al. J Biol Chem, 2001 Jul 6. PMID 11337497, Free PMC Article
  4. Identification and characterization of a novel inositol hexakisphosphate kinase. Saiardi A, et al. J Biol Chem, 2001 Oct 19. PMID 11502751
  5. Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Saiardi A, et al. Curr Biol, 1999 Nov 18. PMID 10574768

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavonoid binding IEA
Inferred from Electronic Annotation
more info
  
enables flavonoid binding ISO
Inferred from Sequence Orthology
more info
  
enables flavonoid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol hexakisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol hexakisphosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol hexakisphosphate 5-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol hexakisphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to flavonoid IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to flavonoid ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to flavonoid ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in inositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in inositol phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in inositol phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphate ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein stabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inositol hexakisphosphate kinase 2
Names
InsP6 kinase 2
P(i)-uptake stimulator
inositol hexaphosphate kinase 2
NP_067692.2
XP_008764786.1
XP_038937971.1
XP_038937972.1
XP_038937973.1
XP_063122126.1
XP_063122127.1
XP_063122128.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021660.2 → NP_067692.2  inositol hexakisphosphate kinase 2

    See identical proteins and their annotated locations for NP_067692.2

    Status: PROVISIONAL

    Source sequence(s)
    BC083574
    UniProtKB/Swiss-Prot
    Q5XIU6, Q9R0U1
    UniProtKB/TrEMBL
    A0A8L2UKG6, A6I382
    Conserved Domains (1) summary
    pfam03770
    Location:202 → 417
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    118362154..118388668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082045.2 → XP_038937973.1  inositol hexakisphosphate kinase 2 isoform X4

    UniProtKB/TrEMBL
    A6I383

  2. XM_039082044.2 → XP_038937972.1  inositol hexakisphosphate kinase 2 isoform X2

  3. XM_008766564.4 → XP_008764786.1  inositol hexakisphosphate kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_008764786.1

    UniProtKB/Swiss-Prot
    Q5XIU6, Q9R0U1
    UniProtKB/TrEMBL
    A0A8L2UKG6, A6I382
    Related
    ENSRNOP00000071056.1
    Conserved Domains (1) summary
    pfam03770
    Location:202 → 417
    IPK; Inositol polyphosphate kinase

  4. XM_063266057.1 → XP_063122127.1  inositol hexakisphosphate kinase 2 isoform X3

  5. XM_063266056.1 → XP_063122126.1  inositol hexakisphosphate kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIU6, Q9R0U1
    UniProtKB/TrEMBL
    A6I382

  6. XM_039082043.2 → XP_038937971.1  inositol hexakisphosphate kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIU6, Q9R0U1
    UniProtKB/TrEMBL
    A0A8L2UKG6, A6I382
    Conserved Domains (1) summary
    pfam03770
    Location:202 → 417
    IPK; Inositol polyphosphate kinase

  7. XM_063266058.1 → XP_063122128.1  inositol hexakisphosphate kinase 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0U1.2 GenPept UniProtKB/Swiss-Prot:Q9R0U1

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