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Tgm1 transglutaminase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60335, updated on 5-Mar-2024

Summary

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Official Symbol
Tgm1provided by RGD
Official Full Name
transglutaminase 1provided by RGD
Primary source
RGD:61838
See related
Ensembl:ENSRNOG00000020136 AllianceGenome:RGD:61838
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in several processes, including keratinocyte differentiation; peptide cross-linking; and positive regulation of keratinocyte proliferation. Predicted to act upstream of or within animal organ morphogenesis. Predicted to be located in adherens junction and membrane. Predicted to be intrinsic component of membrane. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1. Orthologous to human TGM1 (transglutaminase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 44.1), Lung (RPKM 20.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tgm1 in Genome Data Viewer
Location:
15p13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33160985..33175632, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29191039..29206000, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34378136..34393150, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene guanosine monophosphate reductase 2 Neighboring gene TERF1 interacting nuclear factor 2 Neighboring gene Rab geranylgeranyltransferase subunit alpha Neighboring gene tRNA methyltransferase activator subunit 11-2, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney disease. Johnson TS, et al. J Am Soc Nephrol, 2007 Dec. PMID 18003782
  2. Identification and functional characterization of a novel transglutaminase 1 gene mutation associated with autosomal recessive congenital ichthyosis. Zhang SQ, et al. Int J Dermatol, 2016 Feb. PMID 26220141
  3. Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls. Petersen-Jones HG, et al. Am J Physiol Heart Circ Physiol, 2015 Mar 15. PMID 25599570, Free PMC Article
  4. Upregulation of retinal transglutaminase during the axonal elongation stage of goldfish optic nerve regeneration. Sugitani K, et al. Neuroscience, 2006 Nov 3. PMID 16997488
  5. Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions in simple epithelial cells. Hiiragi T, et al. J Biol Chem, 1999 Nov 26. PMID 10567386

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression, activity, and functionality of TG1 and TG2 are decreased in the aorta, but not in the vena cava, from hypertensive rats.
    Title: Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls.
  2. Forced expression of TG1 or TG2 proteins is sufficient to induce neuronal death in Rattus norvegicus cortical neurons in vitro.
    Title: Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.
  3. Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney disease
    Title: Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney disease.
  4. These molecular and cellular data strongly suggest that TG(R) promotes axonal elongation at the surface of injured RGCs after optic nerve injury.
    Title: Upregulation of retinal transglutaminase during the axonal elongation stage of goldfish optic nerve regeneration.
  5. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
    Title: Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-glutamine gamma-glutamyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glutamine gamma-glutamyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-glutamine gamma-glutamyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-glutamine gamma-glutamyltransferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
  
involved_in keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide cross-linking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of keratinocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein-glutamine gamma-glutamyltransferase K
Names
TG(K)
TGK
TGase K
TGase-1
epidermal TGase
glutamine gamma-glutamyltransferase K
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
transglutaminase 1, K polypeptide
transglutaminase K
NP_113847.1
XP_006252076.1
XP_008768913.1
XP_038949552.1
XP_063130669.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031659.1 → NP_113847.1  protein-glutamine gamma-glutamyltransferase K

    See identical proteins and their annotated locations for NP_113847.1

    Status: PROVISIONAL

    Source sequence(s)
    M57263
    UniProtKB/Swiss-Prot
    P23606, Q4QRA6
    UniProtKB/TrEMBL
    A0A8I5ZX14, A6KH40
    Related
    ENSRNOP00000084357.1, ENSRNOT00000119383.1
    Conserved Domains (3) summary
    smart00460
    Location:379 → 470
    TGc; Transglutaminase/protease-like homologues
    pfam00868
    Location:119 → 234
    Transglut_N; Transglutaminase family
    pfam00927
    Location:699 → 796
    Transglut_C; Transglutaminase family, C-terminal ig like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    33160985..33175632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093624.2 → XP_038949552.1  protein-glutamine gamma-glutamyltransferase K isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZX14
    Conserved Domains (3) summary
    smart00460
    Location:343 → 434
    TGc; Transglutaminase/protease-like homologues
    pfam00868
    Location:118 → 234
    Transglut_N; Transglutaminase family
    pfam00927
    Location:663 → 760
    Transglut_C; Transglutaminase family, C-terminal ig like domain

  2. XM_006252014.5 → XP_006252076.1  protein-glutamine gamma-glutamyltransferase K isoform X1

    See identical proteins and their annotated locations for XP_006252076.1

    UniProtKB/Swiss-Prot
    P23606, Q4QRA6
    UniProtKB/TrEMBL
    A0A8I5ZX14, A6KH40
    Related
    ENSRNOP00000027315.2
    Conserved Domains (3) summary
    smart00460
    Location:379 → 470
    TGc; Transglutaminase/protease-like homologues
    pfam00868
    Location:119 → 234
    Transglut_N; Transglutaminase family
    pfam00927
    Location:699 → 796
    Transglut_C; Transglutaminase family, C-terminal ig like domain

  3. XM_008770691.4 → XP_008768913.1  protein-glutamine gamma-glutamyltransferase K isoform X1

    See identical proteins and their annotated locations for XP_008768913.1

    UniProtKB/Swiss-Prot
    P23606, Q4QRA6
    UniProtKB/TrEMBL
    A0A8I5ZX14, A6KH40
    Conserved Domains (3) summary
    smart00460
    Location:379 → 470
    TGc; Transglutaminase/protease-like homologues
    pfam00868
    Location:119 → 234
    Transglut_N; Transglutaminase family
    pfam00927
    Location:699 → 796
    Transglut_C; Transglutaminase family, C-terminal ig like domain

  4. XM_063274599.1 → XP_063130669.1  protein-glutamine gamma-glutamyltransferase K isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23606.1 GenPept UniProtKB/Swiss-Prot:P23606

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