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Fxyd5 FXYD domain-containing ion transport regulator 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60338, updated on 2-May-2024

Summary

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Official Symbol
Fxyd5provided by RGD
Official Full Name
FXYD domain-containing ion transport regulator 5provided by RGD
Primary source
RGD:620827
See related
Ensembl:ENSRNOG00000021062 AllianceGenome:RGD:620827
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RIC
Summary
This reference sequence was derived from multiple replicate ESTs and validated by similar mouse cDNA sequence and human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Three transcript variants encoding the same protein have been found for this gene. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]
Expression
Biased expression in Thymus (RPKM 194.2), Spleen (RPKM 183.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fxyd5 in Genome Data Viewer
Location:
1q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95395327..95404722, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86267937..86277329, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89464853..89474450, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 187, member B Neighboring gene uncharacterized LOC134483094 Neighboring gene uncharacterized LOC134483095 Neighboring gene FXYD domain-containing ion transport regulator 7 Neighboring gene FXYD domain-containing ion transport regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Reduced expression of FXYD domain containing ion transport regulator 5 in association with hypertension. Huang X, et al. Int J Mol Med, 2012 Feb. PMID 22085977
  2. Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis. Ino Y, et al. Proc Natl Acad Sci U S A, 2002 Jan 8. PMID 11756660, Free PMC Article
  3. FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway. Ding L, et al. Bioengineered, 2022 Feb. PMID 35042436, Free PMC Article
  4. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Sweadner KJ, et al. Genomics, 2000 Aug 15. PMID 10950925
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway.
    Title: FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway.
  2. FXYD5 may have profound impact on the regulation of blood pressure.
    Title: Reduced expression of FXYD domain containing ion transport regulator 5 in association with hypertension.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
  
enables ion channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables ion channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
FXYD domain-containing ion transport regulator 5
Names
oncoprotein induced transcript 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270688.1 → NP_001257617.1  FXYD domain-containing ion transport regulator 5 precursor

    See identical proteins and their annotated locations for NP_001257617.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    DV726876, FM112735, FM122563, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P59647, Q6P9W0
    UniProtKB/TrEMBL
    A0A8I6A4C9, A6JA47
    Related
    ENSRNOP00000068919.2, ENSRNOT00000089474.2
    Conserved Domains (1) summary
    pfam02038
    Location:130 → 171
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

  2. NM_001270689.1 → NP_001257618.1  FXYD domain-containing ion transport regulator 5 precursor

    See identical proteins and their annotated locations for NP_001257618.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    DV726876, FM122563, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P59647, Q6P9W0
    UniProtKB/TrEMBL
    A0A8I6A4C9, A6JA47
    Conserved Domains (1) summary
    pfam02038
    Location:130 → 171
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

  3. NM_021909.2 → NP_068709.2  FXYD domain-containing ion transport regulator 5 precursor

    See identical proteins and their annotated locations for NP_068709.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    DV726876, FM112735, FM122563, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P59647, Q6P9W0
    UniProtKB/TrEMBL
    A0A8I6A4C9, A6JA47
    Related
    ENSRNOP00000085788.1, ENSRNOT00000117579.1
    Conserved Domains (1) summary
    pfam02038
    Location:130 → 171
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    95395327..95404722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272422.1 → XP_063128492.1  FXYD domain-containing ion transport regulator 5 isoform X1

    UniProtKB/TrEMBL
    A0A8L2R1T4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59647.2 GenPept UniProtKB/Swiss-Prot:P59647

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