Fhit fragile histidine triad diadenosine triphosphatase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Fhitprovided by RGD
Full Name: fragile histidine triad diadenosine triphosphataseprovided by RGD
Primary source: RGD:620448
See related: Ensembl:ENSRNOG00000064939 AllianceGenome:RGD:620448
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables bis(5'-adenosyl)-triphosphatase activity and nickel cation binding activity. Involved in diadenosine triphosphate catabolic process. Located in cytosol; nucleus; and plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human FHIT (fragile histidine triad diadenosine triphosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 87.8), Brain (RPKM 51.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p15

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (16365401..17872901)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (13935029..15442620)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (15697292..16862873)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircFhit Modulates GABAergic Synaptic Transmission via Regulating the Parental Gene Fhit Expression in the Spinal Dorsal Horn in a Rat Model of Neuropathic Pain.
Title: CircFhit Modulates GABAergic Synaptic Transmission via Regulating the Parental Gene Fhit Expression in the Spinal Dorsal Horn in a Rat Model of Neuropathic Pain.
Nickel(II) treatment down-regulated Fhit expression.
Title: Differential gene expression in nickel(II)-treated normal rat kidney cells.
Distribution of Fhit protein in rat tissues and its intracellular localization.
Title: Distribution of Fhit protein in rat tissues and its intracellular localization.
These results suggest that Fhit alterations may play important roles in hepatocarcinogenesis due to choline deficiency in rats.
Title: Fhit gene alterations in hepatocarcinogenesis induced by a choline-deficient L-amino acid-defined diet in rats.
examination of alterations in N-nitrosodiethylamine-induced hepatocellular carcinoma
Title: Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats.
There is an overall association of Fhit expression with regulatory region methylation, and hypermethylation patterns did not vary with carcinogen.
Title: Hypermethylation patterns in the Fhit regulatory region are tissue specific.

Submit: New GeneRIF Correction

General gene information

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Markers

BE119151 (e-PCR)
- UniSTS:249105

AU048334 (e-PCR)
- UniSTS:109638

AU047515 (e-PCR)
- UniSTS:110432

AU046643 (e-PCR)
- UniSTS:111258

RH144127 (e-PCR)
- UniSTS:233373

D15Rat168 (e-PCR), detects polymorphism
- UniSTS:226727

AU046903 (e-PCR)
- UniSTS:111027

RH144674 (e-PCR)
- UniSTS:233919

AU047671 (e-PCR)
- UniSTS:110279

d15mit2 (e-PCR)
- UniSTS:121032

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adenosine 5'-monophosphoramidase activity	IEA Inferred from Electronic Annotation more info
enables adenosine 5'-monophosphoramidase activity	ISO Inferred from Sequence Orthology more info
enables adenosine 5'-monophosphoramidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables adenylylsulfatase activity	IEA Inferred from Electronic Annotation more info
enables adenylylsulfatase activity	ISO Inferred from Sequence Orthology more info
enables adenylylsulfatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables adenylylsulfate-ammonia adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables adenylylsulfate-ammonia adenylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables adenylylsulfate-ammonia adenylyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables bis(5'-adenosyl)-triphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-adenosyl)-triphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables bis(5'-adenosyl)-triphosphatase activity	IEA Inferred from Electronic Annotation more info
enables bis(5'-adenosyl)-triphosphatase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nickel cation binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	ISO Inferred from Sequence Orthology more info
involved_in diadenosine triphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diadenosine triphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in diadenosine triphosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in diadenosine triphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in purine nucleotide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in purine nucleotide metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bis(5'-adenosyl)-triphosphatase

Names: AP3A hydrolase; AP3Aase; adenosine 5'-monophosphoramidase FHIT; adenylylsulfatase; adenylylsulfate-ammonia adenylyltransferase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase; dinucleosidetriphosphatase; fragile histidine triad protein

NP_068542.1

EC 2.7.7.51

EC 3.6.1.29

EC 3.6.2.1

XP_038949559.1

EC 2.7.7.51

EC 3.6.1.29

EC 3.6.2.1

XP_038949560.1

EC 2.7.7.51

EC 3.6.1.29

EC 3.6.2.1

XP_063130670.1

EC 2.7.7.51

EC 3.6.1.29

EC 3.6.2.1

XP_063130671.1

EC 2.7.7.51

EC 3.6.1.29

EC 3.6.2.1

XP_063130672.1

EC 2.7.7.51

EC 3.6.1.29

EC 3.6.2.1

XP_063130673.1

EC 2.7.7.51

EC 3.6.1.29

EC 3.6.2.1

XP_063130674.1

EC 2.7.7.51

EC 3.6.1.29

EC 3.6.2.1

XP_063130675.1

EC 2.7.7.51

EC 3.6.1.29

EC 3.6.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021774.1 → NP_068542.1 bis(5'-adenosyl)-triphosphatase

See identical proteins and their annotated locations for NP_068542.1

Status: PROVISIONAL

Source sequence(s)

AF170064

UniProtKB/Swiss-Prot

Q9JIX3

UniProtKB/TrEMBL

A0A8I6A955, A0A8I6AAY9

Related

ENSRNOP00000091108.1, ENSRNOT00000110619.1

Conserved Domains (1) summary

cd01275
Location:4 → 124

FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

16365401..17872901

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274603.1 → XP_063130673.1 bis(5'-adenosyl)-triphosphatase isoform X2

UniProtKB/TrEMBL

A0A8I5ZQ19, A6K0A2
XM_063274602.1 → XP_063130672.1 bis(5'-adenosyl)-triphosphatase isoform X2

UniProtKB/TrEMBL

A0A8I5ZQ19, A6K0A2
XM_039093632.2 → XP_038949560.1 bis(5'-adenosyl)-triphosphatase isoform X2

UniProtKB/TrEMBL

A0A8I5ZQ19, A0A8I6A955, A0A8I6AAY9, A6K0A2

Related

ENSRNOP00000080145.1

Conserved Domains (1) summary

cd01275
Location:5 → 124

FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...
XM_063274601.1 → XP_063130671.1 bis(5'-adenosyl)-triphosphatase isoform X2

UniProtKB/TrEMBL

A0A8I5ZQ19, A6K0A2
XM_063274604.1 → XP_063130674.1 bis(5'-adenosyl)-triphosphatase isoform X3
XM_039093631.2 → XP_038949559.1 bis(5'-adenosyl)-triphosphatase isoform X1

UniProtKB/TrEMBL

A0A8I6A955, A0A8I6AAY9

Conserved Domains (1) summary

cd01275
Location:18 → 137

FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...
XM_063274600.1 → XP_063130670.1 bis(5'-adenosyl)-triphosphatase isoform X2

UniProtKB/TrEMBL

A0A8I5ZQ19, A6K0A2
XM_063274605.1 → XP_063130675.1 bis(5'-adenosyl)-triphosphatase isoform X4