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Grm8 glutamate metabotropic receptor 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60590, updated on 4-Jan-2025

Summary

Official Symbol
Grm8provided by RGD
Official Full Name
glutamate metabotropic receptor 8provided by RGD
Primary source
RGD:619858
See related
EnsemblRapid:ENSRNOG00000021468 AllianceGenome:RGD:619858
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Glur8; mGlur; Gprc1h; Mglur8; mGluR8b
Summary
Enables group III metabotropic glutamate receptor activity. Involved in detection of mechanical stimulus involved in sensory perception of pain; glutamatergic synaptic transmission; and modulation of chemical synaptic transmission. Located in neuronal cell body and presynaptic membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone membrane. Used to study Parkinsonism; epilepsy; and visual epilepsy. Human ortholog(s) of this gene implicated in alcohol dependence; attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 78.5) and Muscle (RPKM 6.3) See more
Orthologs
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Genomic context

See Grm8 in Genome Data Viewer
Location:
4q22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (56771247..57696951, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (55805762..56731690, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (54474344..55409526, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102158 Neighboring gene U2 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene U2 spliceosomal RNA Neighboring gene microRNA 592 Neighboring gene uncharacterized LOC120102248 Neighboring gene zinc finger protein 800 Neighboring gene H3 histone, family 3C like 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity  
enables G protein-coupled receptor activity  
enables G protein-coupled receptor activity  
enables glutamate receptor activity  
enables glutamate receptor activity  
enables glutamate receptor activity  
enables group III metabotropic glutamate receptor activity  
enables group III metabotropic glutamate receptor activity PubMed 
enables group III metabotropic glutamate receptor activity  
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway  
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway  
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway  
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway  
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
involved_in chemical synaptic transmission PubMed 
involved_in chemical synaptic transmission PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of pain PubMed 
involved_in presynaptic modulation of chemical synaptic transmission PubMed 
involved_in presynaptic modulation of chemical synaptic transmission PubMed 
involved_in regulation of neurotransmitter secretion PubMed 
involved_in regulation of synaptic transmission, glutamatergic  
involved_in sensory perception of pain PubMed 
involved_in synaptic transmission, glutamatergic PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse PubMed 
is_active_in GABA-ergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
located_in neuronal cell body PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in postsynaptic membrane PubMed 
is_active_in presynaptic active zone membrane PubMed 
located_in presynaptic membrane PubMed 

General protein information

Preferred Names
metabotropic glutamate receptor 8
Names
G protein-coupled receptor, family C, group 1, member H
glutamate receptor, metabotropic 8
metabotropic glutamate receptor subtype 8b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022202.1NP_071538.1  metabotropic glutamate receptor 8 precursor

    See identical proteins and their annotated locations for NP_071538.1

    Status: PROVISIONAL

    Source sequence(s)
    U63288
    UniProtKB/Swiss-Prot
    P70579
    Related
    ENSRNOP00000035953.5, ENSRNOT00000031714.6
    Conserved Domains (4) summary
    cd06376
    Location:44504
    PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
    pfam00003
    Location:595840
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:74478
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:514560
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    56771247..57696951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592855.3XP_017448344.1  metabotropic glutamate receptor 8 isoform X1

    UniProtKB/TrEMBL
    A6IEA3, F1LRA6
    Conserved Domains (3) summary
    cd15454
    Location:582892
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06376
    Location:40504
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
    pfam07562
    Location:512562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  2. XM_017592857.3XP_017448346.1  metabotropic glutamate receptor 8 isoform X2

    UniProtKB/TrEMBL
    F1LRA6
  3. XM_017592856.3XP_017448345.1  metabotropic glutamate receptor 8 isoform X1

    UniProtKB/TrEMBL
    A6IEA3, F1LRA6
    Conserved Domains (3) summary
    cd15454
    Location:582892
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06376
    Location:40504
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
    pfam07562
    Location:512562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  4. XM_017592859.3XP_017448348.1  metabotropic glutamate receptor 8 isoform X1

    UniProtKB/TrEMBL
    A6IEA3, F1LRA6
    Conserved Domains (3) summary
    cd15454
    Location:582892
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06376
    Location:40504
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
    pfam07562
    Location:512562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
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