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Insrr insulin receptor-related receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 60663, updated on 4-Jan-2025

Summary

Official Symbol
Insrrprovided by RGD
Official Full Name
insulin receptor-related receptorprovided by RGD
Primary source
RGD:67399
See related
EnsemblRapid:ENSRNOG00000057702 AllianceGenome:RGD:67399
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sirr
Summary
Predicted to enable insulin receptor activity and insulin receptor substrate binding activity. Involved in protein autophosphorylation. Predicted to be part of insulin receptor complex. Predicted to be active in axon and plasma membrane. Orthologous to human INSRR (insulin receptor related receptor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 46.6), Thymus (RPKM 10.0) and 2 other tissues See more
Orthologs
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Genomic context

See Insrr in Genome Data Viewer
Location:
2q34
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175553244..175572676)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173255335..173274800)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187161817..187181400)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene uncharacterized LOC134485635 Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene SH2 domain containing 2A Neighboring gene proline rich mitotic checkpoint control factor

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables GPI-linked ephrin receptor activity  
enables boss receptor activity  
enables brain-derived neurotrophic factor receptor activity  
enables epidermal growth factor receptor activity  
enables fibroblast growth factor receptor activity  
enables hepatocyte growth factor receptor activity  
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables insulin receptor activity  
enables insulin receptor substrate binding  
enables insulin-like growth factor receptor activity  
enables macrophage colony-stimulating factor receptor activity  
enables phosphatidylinositol 3-kinase binding  
enables placental growth factor receptor activity  
enables platelet-derived growth factor alpha-receptor activity  
enables platelet-derived growth factor beta-receptor activity  
enables protein tyrosine kinase collagen receptor activity  
enables stem cell factor receptor activity  
enables transmembrane receptor protein tyrosine kinase activity  
enables transmembrane receptor protein tyrosine kinase activity  
enables transmembrane-ephrin receptor activity  
enables vascular endothelial growth factor receptor activity  
Process Evidence Code Pubs
involved_in Kit signaling pathway  
involved_in actin cytoskeleton organization  
involved_in actin cytoskeleton organization  
involved_in brain-derived neurotrophic factor receptor signaling pathway  
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
involved_in cellular response to alkaline pH  
involved_in chromatin remodeling  
involved_in collagen-activated tyrosine kinase receptor signaling pathway  
involved_in ephrin receptor signaling pathway  
involved_in epidermal growth factor receptor signaling pathway  
involved_in fibroblast growth factor receptor signaling pathway  
involved_in hepatocyte growth factor receptor signaling pathway  
involved_in insulin receptor signaling pathway  
involved_in insulin-like growth factor receptor signaling pathway  
involved_in macrophage colony-stimulating factor signaling pathway  
acts_upstream_of_or_within male sex determination  
involved_in multicellular organism development  
involved_in platelet-derived growth factor receptor-alpha signaling pathway  
involved_in platelet-derived growth factor receptor-beta signaling pathway  
involved_in protein autophosphorylation PubMed 
involved_in protein autophosphorylation  
involved_in vascular endothelial growth factor receptor-1 signaling pathway  
involved_in vascular endothelial growth factor signaling pathway  
Component Evidence Code Pubs
is_active_in axon  
part_of insulin receptor complex  
is_active_in plasma membrane  
part_of receptor complex  

General protein information

Preferred Names
insulin receptor-related protein
Names
IR-related receptor
IRR
NP_071548.2
XP_063138512.1
XP_063138513.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022212.2NP_071548.2  insulin receptor-related protein precursor

    See identical proteins and their annotated locations for NP_071548.2

    Status: PROVISIONAL

    Source sequence(s)
    CH473976
    UniProtKB/Swiss-Prot
    Q63146, Q64716
    UniProtKB/TrEMBL
    A6J619
    Related
    ENSRNOP00000073224.1, ENSRNOT00000080693.4
    Conserved Domains (6) summary
    cd05032
    Location:9721248
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:819908
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:228275
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:173326
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:346460
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:9791246
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    175553244..175572676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282442.1XP_063138512.1  insulin receptor-related protein isoform X1

  2. XM_063282443.1XP_063138513.1  insulin receptor-related protein isoform X2

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