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Entpd8 ectonucleoside triphosphate diphosphohydrolase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 613267, updated on 13-Apr-2024

Summary

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Symbol
Entpd8provided by RGD
Full Name
ectonucleoside triphosphate diphosphohydrolase 8provided by RGD
Primary source
RGD:1561793
See related
Ensembl:ENSRNOG00000009239 AllianceGenome:RGD:1561793
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanosine-diphosphatase activity; nucleoside-triphosphatase activity; and uridine-diphosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process. Predicted to act upstream of or within nucleoside diphosphate biosynthetic process and nucleoside monophosphate biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human ENTPD8 (ectonucleoside triphosphate diphosphohydrolase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 70.2), Uterus (RPKM 5.3) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Entpd8 in Genome Data Viewer
Location:
3p13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28283392..28295686)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (7885277..7895517)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2286363..2299720)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene patatin-like phospholipase domain containing 7 Neighboring gene glutathione S-transferase pi 1, pseudogene 3 Neighboring gene NMDA receptor synaptonuclear signaling and neuronal migration factor Neighboring gene NADPH oxidase activator 1 Neighboring gene uncharacterized LOC134486058 Neighboring gene Notch-regulated ankyrin repeat protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of expressed human ecto-nucleoside triphosphate diphosphohydrolase 8 (E-NTPDase 8) and its soluble extracellular domain. Knowles AF, et al. Biochemistry, 2006 Jun 13. PMID 16752921
  2. Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8. Bigonnesse F, et al. Biochemistry, 2004 May 11. PMID 15122917
  3. Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8. Fausther M, et al. Am J Physiol Gastrointest Liver Physiol, 2007 Mar. PMID 17095758, Free PMC Article
  4. Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8. Kukulski F, et al. Purinergic Signal, 2005 Jun. PMID 18404504, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NTPDase8 is the canalicular ecto-ATPase/ATPDase and is responsible for the main hepatic NTPDase activity.
    Title: Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables apyrase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside triphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside triphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in nucleoside diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleoside diphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleoside diphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleoside monophosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ectonucleoside triphosphate diphosphohydrolase 8
Names
E-NTPDase 8
NTPDase 8
NTPDase8
NP_001028737.2
XP_006233701.1
XP_038961703.1
XP_063140549.1
XP_063140550.1
XP_063140551.1
XP_063140552.1
XP_063140553.1
XP_063140554.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033565.2 → NP_001028737.2  ectonucleoside triphosphate diphosphohydrolase 8

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q5DRK1
    Related
    ENSRNOP00000012289.7, ENSRNOT00000012289.8
    Conserved Domains (1) summary
    cl17037
    Location:34 → 454
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    28283392..28295686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284483.1 → XP_063140553.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X3

  2. XM_063284484.1 → XP_063140554.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X4

  3. XM_063284479.1 → XP_063140549.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X1

  4. XM_039105775.2 → XP_038961703.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X1

    UniProtKB/Swiss-Prot
    Q5DRK1
    Conserved Domains (1) summary
    cl17037
    Location:34 → 459
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  5. XM_006233639.4 → XP_006233701.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X1

    See identical proteins and their annotated locations for XP_006233701.1

    UniProtKB/Swiss-Prot
    Q5DRK1
    Conserved Domains (1) summary
    cl17037
    Location:34 → 459
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  6. XM_063284481.1 → XP_063140551.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X2

  7. XM_063284482.1 → XP_063140552.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X2

  8. XM_063284480.1 → XP_063140550.1  ectonucleoside triphosphate diphosphohydrolase 8 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DRK1.1 GenPept UniProtKB/Swiss-Prot:Q5DRK1

Gene LinkOut

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