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ZNF704 zinc finger protein 704 [ Homo sapiens (human) ]

Gene ID: 619279, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF704provided by HGNC
Official Full Name
zinc finger protein 704provided by HGNC
Primary source
HGNC:HGNC:32291
See related
Ensembl:ENSG00000164684 AllianceGenome:HGNC:32291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Gig1
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 8.6), ovary (RPKM 8.1) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
8q21.13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (80628451..80884419, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (81060029..81315991, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (81540686..81787016, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene SLC25A51 pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 107, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:81552571-81553770 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:81610513-81611014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:81611015-81611514 Neighboring gene RNA, U11 small nuclear 6, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 308, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:81734976-81736175 Neighboring gene high mobility group box 1 pseudogene 41 Neighboring gene MPRA-validated peak7088 silencer Neighboring gene uncharacterized LOC107986894 Neighboring gene HNF4 motif-containing MPRA enhancer 108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27570 Neighboring gene uncharacterized LOC124901967 Neighboring gene phosphoprotein membrane anchor with glycosphingolipid microdomains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis. Yang C, et al. Cancer Res, 2020 Oct 1. PMID 32651256
  2. A four-gene transcript score to predict metastatic-lethal progression in men treated for localized prostate cancer: Development and validation studies. Cheng A, et al. Prostate, 2019 Oct. PMID 31376183, Free PMC Article
  3. DNA Damage Regulates Translation through β-TRCP Targeting of CReP. Loveless TB, et al. PLoS Genet, 2015 Jun. PMID 26091241, Free PMC Article
  4. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Kim TY, et al. Mol Cell Biol, 2015 Jan. PMID 25332235, Free PMC Article
  5. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis.
    Title: Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis.
  2. tumor marker zinc finger protein 704 as part of a four gene transcript score has prognostic value for metastatic-lethal progression in men treated for localized prostate cancer
    Title: A four-gene transcript score to predict metastatic-lethal progression in men treated for localized prostate cancer: Development and validation studies.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16218, MGC10858

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 704

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033723.3 → NP_001028895.1  zinc finger protein 704 isoform 1

    See identical proteins and their annotated locations for NP_001028895.1

    Status: VALIDATED

    Source sequence(s)
    AC022598, AK131274, BC004287, BM683148, BX112159
    Consensus CDS
    CCDS34913.1
    UniProtKB/Swiss-Prot
    B2RNE6, B9EGW6, Q6ZNC4
    Related
    ENSP00000331462.3, ENST00000327835.7
    Conserved Domains (1) summary
    cl25496
    Location:248 → 374
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  2. NM_001367783.1 → NP_001354712.1  zinc finger protein 704 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022598, AC024367
    Consensus CDS
    CCDS94322.1
    UniProtKB/TrEMBL
    E5RGL7
    Related
    ENSP00000427715.2, ENST00000519936.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    80628451..80884419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013725.2 → XP_016869214.1  zinc finger protein 704 isoform X1

RNA

  1. XR_928797.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    81060029..81315991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360961.1 → XP_054216936.1  zinc finger protein 704 isoform X1

RNA

  1. XR_008487869.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032651.1: Suppressed sequence

    Description
    NM_032651.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZNC4.1 GenPept UniProtKB/Swiss-Prot:Q6ZNC4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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