U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SAA@ serum amyloid A1 cluster [ Homo sapiens (human) ]

Gene ID: 6287, discontinued on 11-Oct-2019
  • This record was withdrawn by the HUGO Gene Nomenclature Committee (HGNC).

Summary

Go to the top of the page Help
Official Symbol
SAA@provided by HGNC
Official Full Name
serum amyloid A1 clusterprovided by HGNC
Primary source
HGNC:HGNC:10512
Gene type
other
RefSeq status
WITHDRAWN
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAA; SAA4
Summary
DISCONTINUED: This record was withdrawn by the HUGO Gene Nomenclature Committee (HGNC).
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11p

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High serum SAA levels are associated with squamous cell cervical cancer.
    Title: Twelve serum proteins progressively increase with disease stage in squamous cell cervical cancer patients.
  2. High Serum amyloid A is associated with renal cell carcinoma.
    Title: Serum amyloid a as an independent prognostic factor for renal cell carcinoma--a hospital based study from the Western region of Nepal.
  3. SAA is a significant inducer of IL-23 and IL-1beta in rheumatoid arthritis (RA) synoviocytes and potentially activates the IL-23/IL-17 pathway in the RA synovium.
    Title: Induction of interleukin-23 p19 by serum amyloid A (SAA) in rheumatoid synoviocytes.
  4. Our results point to SAA as an important link of innate to adaptive immunity, once it might act on the recruitment of mononuclear cells.
    Title: Serum amyloid A induces CCL20 secretion in mononuclear cells through MAPK (p38 and ERK1/2) signaling pathways.
  5. serum Amyloid A concentration is increased in obese children and adolescents
    Title: Serum Amyloid A concentration is increased in obese children and adolescents.
  6. SAA is a significant inducer of IL-6, which is critically involved in rheumatoid arthritis pathogenesis.
    Title: Serum amyloid A-induced IL-6 production by rheumatoid synoviocytes.
  7. Together, the data indicate that SAA enhances plasminogen activation and suggest its possible role in plasmin(ogen)-mediated colon cancer progression.
    Title: Serum amyloid A enhances plasminogen activation: implication for a role in colon cancer.
  8. Serum amyloid A appears to be important mediator of inflammatory process, possibly contributing to pool of IL-8 produced in chronic diseases, which may play a role in degenerative diseases
    Title: mRNA expression and release of interleukin-8 induced by serum amyloid A in neutrophils and monocytes.
  9. SAA is an endogenous ligand that potentially activates IL-12p40 synthesis and secretion, and differentially regulates expression of IL-12 and IL-23 through preferential induction of IL-23p19.
    Title: Serum amyloid A is an endogenous ligand that differentially induces IL-12 and IL-23.
  10. human serum amyloid A (SAA) gene is induced by IL-6
    Title: IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Other Names

  • serum amyloid A cluster

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.