Slc33a1 solute carrier family 33 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc33a1provided by RGD
Official Full Name: solute carrier family 33 member 1provided by RGD
Primary source: RGD:620653
See related: Ensembl:ENSRNOG00000010023 AllianceGenome:RGD:620653
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Acatn
Summary: Predicted to enable solute:proton symporter activity. Predicted to be involved in BMP signaling pathway and SMAD protein signal transduction. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 42. Orthologous to human SLC33A1 (solute carrier family 33 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 245.5), Kidney (RPKM 221.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (150565327..150587700, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (148415660..148438182, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (154520170..154542981, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH128989 (e-PCR)
- UniSTS:212297

AI315656 (e-PCR)
- UniSTS:159123

AI788741 (e-PCR)
- UniSTS:178840

BF389636 (e-PCR)
- UniSTS:245501

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetyl-CoA transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables acetyl-CoA transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables acetyl-CoA transmembrane transporter activity	NAS Non-traceable Author Statement more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in acetyl-CoA transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: acetyl-coenzyme A transporter 1

Names: AT-1; acetyl-CoA transporter 1; acetyl-coenzyme A transporter 1-like; solute carrier family 33 (acetyl-CoA transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022252.2 → NP_071588.2 acetyl-coenzyme A transporter 1

See identical proteins and their annotated locations for NP_071588.2

Status: PROVISIONAL

Source sequence(s)

BC078832

UniProtKB/Swiss-Prot

Q6AYY8, Q9JM68

UniProtKB/TrEMBL

A6JVP5

Related

ENSRNOP00000013392.3, ENSRNOT00000013392.6

Conserved Domains (1) summary

TIGR00901
Location:86 → 459

2A0125; AmpG-like permease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

150565327..150587700 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761058.2 → XP_008759280.1 acetyl-coenzyme A transporter 1 isoform X1

See identical proteins and their annotated locations for XP_008759280.1

UniProtKB/Swiss-Prot

Q6AYY8, Q9JM68

UniProtKB/TrEMBL

A6JVP5

Conserved Domains (1) summary

TIGR00901
Location:86 → 459

2A0125; AmpG-like permease
XM_039103030.2 → XP_038958958.1 acetyl-coenzyme A transporter 1 isoform X3

Conserved Domains (1) summary

cl28910
Location:48 → 270

MFS; Major Facilitator Superfamily
XM_063282448.1 → XP_063138518.1 acetyl-coenzyme A transporter 1 isoform X2
XM_039103029.2 → XP_038958957.1 acetyl-coenzyme A transporter 1 isoform X2

Conserved Domains (1) summary

cl28910
Location:14 → 236

MFS; Major Facilitator Superfamily