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Mafg MAF bZIP transcription factor G [ Rattus norvegicus (Norway rat) ]

Gene ID: 64188, updated on 2-May-2024

Summary

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Official Symbol
Mafgprovided by RGD
Official Full Name
MAF bZIP transcription factor Gprovided by RGD
Primary source
RGD:619953
See related
Ensembl:ENSRNOG00000036697 AllianceGenome:RGD:619953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in regulation of cellular pH. Predicted to be active in nucleus. Orthologous to human MAFG (MAF bZIP transcription factor G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 74.3), Kidney (RPKM 63.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mafg in Genome Data Viewer
Location:
10q32.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106401633..106410159, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105903307..105911808, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109802877..109811476, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene sirtuin 7 Neighboring gene pyrroline-5-carboxylate reductase 1 Neighboring gene myeloid-associated differentiation marker-like 2 Neighboring gene NOTUM, palmitoleoyl-protein carboxylesterase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MafG-2 is a novel Maf protein that is expressed by stimulation of extracellular H(+). Shimokawa N, et al. Cell Signal, 2001 Nov. PMID 11583919
  2. Cloning of MafG homologue from the rat brain by differential display and its expression after hypercapnic stimulation. Shimokawa N, et al. Mol Cell Biochem, 2000 Jan. PMID 10724342
  3. Extracellular acidification enhances DNA binding activity of MafG-FosB heterodimer. Shimokawa N, et al. J Cell Physiol, 2005 Oct. PMID 15828020
  4. Nrf2 transcriptionally activates the mafG gene through an antioxidant response element. Katsuoka F, et al. J Biol Chem, 2005 Feb 11. PMID 15574414
  5. Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice. Shavit JA, et al. Genes Dev, 1998 Jul 15. PMID 9679061, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the up-regulation of TCF11/MafG binding could be suppressed by overexpression of the TGF-beta inhibitor Smad7, and a small interfering RNA to TCF11 blocked the suppression of iNOS by TGF-beta.
    Title: Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11.
  2. MafG-FBJ osteosarcoma oncogene B complexes are involved in transcriptional regulation in response to extracellular acidification
    Title: Extracellular acidification enhances DNA binding activity of MafG-FosB heterodimer.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adult behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular pH IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of epidermal cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of epidermal cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor MafG
Names
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022386.4 → NP_071781.1  transcription factor MafG

    See identical proteins and their annotated locations for NP_071781.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    106401633..106410159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269808.1 → XP_063125878.1  transcription factor MafG isoform X2

    UniProtKB/Swiss-Prot
    Q76MX4, Q99N83
    UniProtKB/TrEMBL
    A6HLH1

  2. XM_063269811.1 → XP_063125881.1  transcription factor MafG isoform X3

  3. XM_039086788.2 → XP_038942716.1  transcription factor MafG isoform X3

    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

  4. XM_006247921.5 → XP_006247983.1  transcription factor MafG isoform X3

    See identical proteins and their annotated locations for XP_006247983.1

    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

  5. XM_063269810.1 → XP_063125880.1  transcription factor MafG isoform X2

    UniProtKB/Swiss-Prot
    Q76MX4, Q99N83
    UniProtKB/TrEMBL
    A6HLH1

  6. XM_039086787.2 → XP_038942715.1  transcription factor MafG isoform X3

    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

  7. XM_063269809.1 → XP_063125879.1  transcription factor MafG isoform X2

    UniProtKB/Swiss-Prot
    Q76MX4, Q99N83
    UniProtKB/TrEMBL
    A6HLH1

  8. XM_006247922.5 → XP_006247984.1  transcription factor MafG isoform X3

    See identical proteins and their annotated locations for XP_006247984.1

    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

  9. XM_063269807.1 → XP_063125877.1  transcription factor MafG isoform X2

    UniProtKB/Swiss-Prot
    Q76MX4, Q99N83
    UniProtKB/TrEMBL
    A6HLH1

  10. XM_006247913.5 → XP_006247975.1  transcription factor MafG isoform X1

    UniProtKB/TrEMBL
    A0A8L2QQP9
    Related
    ENSRNOP00000051853.2
    Conserved Domains (1) summary
    cd14717
    Location:103 → 172
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

  11. XM_008768482.4 → XP_008766704.1  transcription factor MafG isoform X3

    See identical proteins and their annotated locations for XP_008766704.1

    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q76MX4.2 GenPept UniProtKB/Swiss-Prot:Q76MX4

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