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Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64189, updated on 11-Apr-2024

Summary

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Official Symbol
Pafah1b2provided by RGD
Official Full Name
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2provided by RGD
Primary source
RGD:620332
See related
Ensembl:ENSRNOG00000057102 AllianceGenome:RGD:620332
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity; identical protein binding activity; and platelet-activating factor acetyltransferase activity. Involved in brain development. Located in cytosol. Part of 1-alkyl-2-acetylglycerophosphocholine esterase complex. Human ortholog(s) of this gene implicated in lymphoma. Orthologous to human PAFAH1B2 (platelet activating factor acetylhydrolase 1b catalytic subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 343.2), Adrenal (RPKM 234.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pafah1b2 in Genome Data Viewer
Location:
8q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (55156778..55208800, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46260069..46312073, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50256969..50310043, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094332 Neighboring gene transgelin Neighboring gene SID1 transmembrane family, member 2 Neighboring gene ribosomal protein S26, pseudogene 6 Neighboring gene uncharacterized LOC120094333 Neighboring gene SIK family kinase 3 Neighboring gene POU class 5 homeobox 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MicroRNA-212-5p and its target PAFAH1B2 suppress vascular proliferation and contraction via the downregulation of RhoA. Kim GR, et al. PLoS One, 2021. PMID 33760887, Free PMC Article
  2. Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit. Bonin F, et al. J Biol Chem, 2004 Dec 10. PMID 15456758
  3. Switching of platelet-activating factor acetylhydrolase catalytic subunits in developing rat brain. Manya H, et al. J Biol Chem, 1998 Jul 17. PMID 9660828
  4. Molecular cloning of cDNAs encoding alpha1, alpha2, and beta subunits of rat brain platelet-activating factor acetylhydrolase. Watanabe M, et al. Biochim Biophys Acta, 1998 Jan 2. PMID 9459487
  5. Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE. Kitagawa M, et al. FEBS Lett, 2000 Aug 11. PMID 10940388

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-212-5p and its target PAFAH1B2 suppress vascular proliferation and contraction via the downregulation of RhoA.
    Title: MicroRNA-212-5p and its target PAFAH1B2 suppress vascular proliferation and contraction via the downregulation of RhoA.
  2. the PAF receptor-independent death pathway is regulated by PAF-AH I alpha2
    Title: Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC93124

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables platelet-activating factor acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables platelet-activating factor acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables platelet-activating factor acetyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
platelet-activating factor acetylhydrolase IB subunit alpha2
Names
PAF acetylhydrolase 30 kDa subunit
PAF-AH 30 kDa subunit
PAF-AH alpha 2
PAF-AH subunit beta
PAFAH subunit beta
platelet-activating factor acetylhydrolase IB subunit beta
platelet-activating factor acetylhydrolase alpha 2 subunit (PAF-AH alpha 2)
NP_071782.1
XP_006243020.1
XP_038938009.1
XP_038938010.1
XP_063122144.1
XP_063122145.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022387.3 → NP_071782.1  platelet-activating factor acetylhydrolase IB subunit alpha2

    See identical proteins and their annotated locations for NP_071782.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081714
    UniProtKB/Swiss-Prot
    O35264
    UniProtKB/TrEMBL
    A0A8L2R003, A6J468
    Related
    ENSRNOP00000091075.1, ENSRNOT00000111151.1
    Conserved Domains (1) summary
    cd01820
    Location:8 → 217
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    55156778..55208800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242958.5 → XP_006243020.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

    See identical proteins and their annotated locations for XP_006243020.1

    UniProtKB/Swiss-Prot
    O35264
    UniProtKB/TrEMBL
    A0A8L2R003, A6J468
    Conserved Domains (1) summary
    cd01820
    Location:8 → 217
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

  2. XM_039082082.2 → XP_038938010.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

    UniProtKB/Swiss-Prot
    O35264
    UniProtKB/TrEMBL
    A0A8L2R003, A6J468
    Conserved Domains (1) summary
    cd01820
    Location:8 → 217
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

  3. XM_063266075.1 → XP_063122145.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

    UniProtKB/Swiss-Prot
    O35264
    UniProtKB/TrEMBL
    A6J468

  4. XM_039082081.2 → XP_038938009.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

    UniProtKB/Swiss-Prot
    O35264
    UniProtKB/TrEMBL
    A0A8L2R003, A6J468
    Conserved Domains (1) summary
    cd01820
    Location:8 → 217
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

  5. XM_063266074.1 → XP_063122144.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

    UniProtKB/Swiss-Prot
    O35264
    UniProtKB/TrEMBL
    A6J468
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35264.1 GenPept UniProtKB/Swiss-Prot:O35264

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