Rasd1 ras related dexamethasone induced 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rasd1provided by RGD
Official Full Name: ras related dexamethasone induced 1provided by RGD
Primary source: RGD:619727
See related: Ensembl:ENSRNOG00000003348 AllianceGenome:RGD:619727
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in negative regulation of transcription, DNA-templated and nitric oxide mediated signal transduction. Located in nucleus and perinuclear region of cytoplasm. Orthologous to human RASD1 (ras related dexamethasone induced 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 60.9), Adrenal (RPKM 22.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (45265975..45275279, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (44766451..44775773, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (46330361..46339326, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dexras1 Induces Dysdifferentiation of Oligodendrocytes and Myelin Injury by Inhibiting the cAMP-CREB Pathway after Subarachnoid Hemorrhage.
Title: Dexras1 Induces Dysdifferentiation of Oligodendrocytes and Myelin Injury by Inhibiting the cAMP-CREB Pathway after Subarachnoid Hemorrhage.
Rasd1 is an estrogen-responsive immediate early gene and modulates E2 induction of at least several late genes in anterior pituitary cells.
Title: Rasd1 is an estrogen-responsive immediate early gene and modulates expression of late genes in rat anterior pituitary cells.
The Dexras1 protein is expressed predominantly in the dorsomedial part of thesuprachiasmatic nucleus and the light pulse has only a limited effect on its expression
Title: Circadian Dexras1 in rats: Development, location and responsiveness to light.
two mechanisms of Rasd1 induction in the hypothalamus, were identified.
Title: Rasd1, a small G protein with a big role in the hypothalamic response to neuronal activation.
RASD1 is downregulated by calycosin in cerebral ischemia/reperfusion injury and provides a protective effect.
Title: Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats.
Ras dexamethasone-induced protein 1 is a modulator of hormone secretion in the volume overloaded heart.
Title: Ras dexamethasone-induced protein 1 is a modulator of hormone secretion in the volume overloaded heart.
NOS inhibition prevents retinal ganglion cell apoptosis by decreasing cleaved caspase-3 and Dexras1 expression
Title: Light-induced retinal ganglion cell damage in vivo involves Dexras1.
Data suggest that Dexras 1 is involved in CNS cell death and demyelination in EAE through nitric oxide signaling by binding to nNOS and CAPON.
Title: Spatiotemporal patterns of dexamethasone-induced Ras protein 1 expression in the central nervous system of rats with experimental autoimmune encephalomyelitis.
Dexras1 functions as a suppressor of FE65-APP-mediated transcription, and FE65 tyrosine 547 phosphorylation enhances FE65-APP-mediated transcription, at least in part, by modulating the interaction between FE65 and Dexras1
Title: Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.
Transient high expression of Dexras1 which localized in apoptotic neurons and pathological oligodendrocytes after spinal cord transection.
Title: Spatiotemporal expression of Dexras1 after spinal cord transection in rats.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

RH128385 (e-PCR)
- UniSTS:211693

RH132250 (e-PCR)
- UniSTS:215533

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitric oxide mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dexamethasone-induced Ras-related protein 1

Names: DEXRAS1 (Dexras1); RAS, dexamethasone-induced 1

NP_001257883.1

EC 3.6.5.2

XP_008766093.1

EC 3.6.5.2

XP_038942720.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270954.1 → NP_001257883.1 dexamethasone-induced Ras-related protein 1

See identical proteins and their annotated locations for NP_001257883.1

Status: PROVISIONAL

Source sequence(s)

BC099136

UniProtKB/Swiss-Prot

Q4KLL2, Q9JKF8

UniProtKB/TrEMBL

A6HF22

Related

ENSRNOP00000004475.4, ENSRNOT00000004475.7

Conserved Domains (1) summary

cd04143
Location:25 → 280

Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

45265975..45275279 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086792.2 → XP_038942720.1 dexamethasone-induced Ras-related protein 1 isoform X1

UniProtKB/Swiss-Prot

Q4KLL2, Q9JKF8

UniProtKB/TrEMBL

A6HF22

Conserved Domains (1) summary

cd04143
Location:25 → 280

Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)
XM_008767871.4 → XP_008766093.1 dexamethasone-induced Ras-related protein 1 isoform X1

See identical proteins and their annotated locations for XP_008766093.1

UniProtKB/Swiss-Prot

Q4KLL2, Q9JKF8

UniProtKB/TrEMBL

A6HF22

Conserved Domains (1) summary

cd04143
Location:25 → 280

Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)