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Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64473, updated on 12-May-2024

Summary

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Official Symbol
Bpnt1provided by RGD
Official Full Name
3'(2'), 5'-bisphosphate nucleotidase 1provided by RGD
Primary source
RGD:621833
See related
Ensembl:ENSRNOG00000002378 AllianceGenome:RGD:621833
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sal3; RnPIP
Summary
Enables 3'(2'),5'-bisphosphate nucleotidase activity; inositol-1,4-bisphosphate 1-phosphatase activity; and magnesium ion binding activity. Predicted to be involved in inositol phosphate dephosphorylation and phosphatidylinositol phosphate biosynthetic process. Orthologous to human BPNT1 (3'(2'), 5'-bisphosphate nucleotidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 248.0), Adrenal (RPKM 230.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bpnt1 in Genome Data Viewer
Location:
13q26
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (99397127..99425056)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (96865634..96893506)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (103268045..103292848)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene isoleucyl-tRNA synthetase 2, mitochondrial Neighboring gene microRNA 194-1 Neighboring gene microRNA 215 Neighboring gene uncharacterized LOC134481540 Neighboring gene glutamyl-prolyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC100911719 Neighboring gene solute carrier family 30, member 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel mammalian lithium-sensitive enzyme with a dual enzymatic activity, 3'-phosphoadenosine 5'-phosphate phosphatase and inositol-polyphosphate 1-phosphatase. López-Coronado JM, et al. J Biol Chem, 1999 Jun 4. PMID 10347153
  2. Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy. Patel S, et al. J Mol Biol, 2002 Jan 25. PMID 11812139
  3. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. Spiegelberg BD, et al. J Biol Chem, 1999 May 7. PMID 10224133
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93112

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'(2'),5'-bisphosphate nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'(2'),5'-bisphosphate nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3'(2'),5'-bisphosphate nucleotidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,4-bisphosphate 1-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3'(2'),5'-bisphosphate nucleotidase 1
Names
3'-phosphoadenosine 5'-phosphate phosphatase
BPntase 1
PAP phosphatase
PAP-inositol 1,4-phosphatase
PIP
bisphosphate 3'-nucleotidase 1
inositol-polyphosphate 1-phosphatase
scHAL2 analogous 3
NP_741987.1
XP_006250491.1
XP_006250492.1
XP_006250493.1
XP_038946992.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_171990.2 → NP_741987.1  3'(2'),5'-bisphosphate nucleotidase 1

    See identical proteins and their annotated locations for NP_741987.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085692
    UniProtKB/Swiss-Prot
    Q9Z1N4
    UniProtKB/TrEMBL
    A0A8L2Q072, A6JGQ8
    Conserved Domains (1) summary
    cd01640
    Location:11 → 297
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    99397127..99425056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091064.2 → XP_038946992.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0V3, A0A8L2Q072, A6JGQ7
    Conserved Domains (1) summary
    cd01640
    Location:11 → 312
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

  2. XM_006250429.4 → XP_006250491.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006250491.1

    UniProtKB/TrEMBL
    A0A0G2K0V3, A0A8L2Q072, A6JGQ7
    Related
    ENSRNOP00000071594.1
    Conserved Domains (1) summary
    cd01640
    Location:11 → 312
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

  3. XM_006250431.5 → XP_006250493.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X2

    See identical proteins and their annotated locations for XP_006250493.1

    UniProtKB/Swiss-Prot
    Q9Z1N4
    UniProtKB/TrEMBL
    A0A8L2Q072, A6JGQ8
    Conserved Domains (1) summary
    cd01640
    Location:11 → 297
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

  4. XM_006250430.5 → XP_006250492.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006250492.1

    UniProtKB/TrEMBL
    A0A0G2K0V3, A0A8L2Q072, A6JGQ7
    Conserved Domains (1) summary
    cd01640
    Location:11 → 312
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1N4.1 GenPept UniProtKB/Swiss-Prot:Q9Z1N4

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