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Rbm10 RNA binding motif protein 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64510, updated on 13-Apr-2024

Summary

Official Symbol
Rbm10provided by RGD
Official Full Name
RNA binding motif protein 10provided by RGD
Primary source
RGD:631366
See related
Ensembl:ENSRNOG00000008472 AllianceGenome:RGD:631366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and miRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within negative regulation of RNA metabolic process; negative regulation of cell population proliferation; and positive regulation of smooth muscle cell apoptotic process. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in TARP syndrome. Orthologous to human RBM10 (RNA binding motif protein 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 168.9), Spleen (RPKM 125.3) and 9 other tissues See more
Orthologs
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Genomic context

Location:
Xq11
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (4093914..4126060, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (1540399..1572571, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (1754869..1786973, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 16 Neighboring gene ubiquitin-like modifier activating enzyme 1 Neighboring gene U2 spliceosomal RNA Neighboring gene NADH:ubiquinone oxidoreductase subunit B11

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables miRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle cell myoblast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell growth involved in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ribosomal large subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of vascular associated smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular associated smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of vascular associated smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular associated smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RNA-binding protein 10
Names
RNA-binding protein S1-1
S1-1 protein from liver

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414396.1NP_001401325.1  RNA-binding protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I6ACC8
    Related
    ENSRNOP00000090693.1, ENSRNOT00000111814.1
  2. NM_152861.5NP_690600.1  RNA-binding protein 10 isoform 1

    See identical proteins and their annotated locations for NP_690600.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    P70501
    UniProtKB/TrEMBL
    A0A8I6A0D6, A6JZT5
    Related
    ENSRNOP00000011317.5, ENSRNOT00000011317.7
    Conserved Domains (7) summary
    smart00547
    Location:138162
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:211321
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12754
    Location:221307
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00025
    Location:140159
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam01585
    Location:780824
    G-patch; G-patch domain
    cd16167
    Location:486549
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    cl17169
    Location:67134
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    4093914..4126060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280282.1XP_063136352.1  RNA-binding protein 10 isoform X2

  2. XM_063280281.1XP_063136351.1  RNA-binding protein 10 isoform X1

    UniProtKB/TrEMBL
    A6JZT6
  3. XM_039100026.2XP_038955954.1  RNA-binding protein 10 isoform X4

    Conserved Domains (5) summary
    smart00547
    Location:1236
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:1433
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:360423
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:654698
    G-patch; G-patch domain
    cd12754
    Location:95181
    RRM2_RBM10; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 10 (RBM10)
  4. XM_039100025.2XP_038955953.1  RNA-binding protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A0D6
    Conserved Domains (6) summary
    smart00547
    Location:5478
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:5675
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:402465
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:696740
    G-patch; G-patch domain
    cd12754
    Location:137223
    RRM2_RBM10; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 10 (RBM10)
    cl17169
    Location:150
    RRM_SF; RNA recognition motif (RRM) superfamily