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Ech1 enoyl-CoA hydratase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64526, updated on 2-May-2024

Summary

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Official Symbol
Ech1provided by RGD
Official Full Name
enoyl-CoA hydratase 1provided by RGD
Primary source
RGD:69353
See related
Ensembl:ENSRNOG00000020308 AllianceGenome:RGD:69353
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pxel
Summary
Predicted to enable delta3,5-delta2,4-dienoyl-CoA isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Orthologous to human ECH1 (enoyl-CoA hydratase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 3119.7), Muscle (RPKM 1008.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ech1 in Genome Data Viewer
Location:
1q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93241076..93248314)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84114494..84120788)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (87009798..87015996)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene uncharacterized LOC134483092 Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene Ras and Rab interactor-like Neighboring gene galectin 4 Neighboring gene galectin 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis. Modis Y, et al. Structure, 1998 Aug 15. PMID 9739087
  2. Enoyl coenzyme A hydratase 1 combats obesity and related metabolic disorders by promoting adipose tissue browning. Mao X, et al. Am J Physiol Endocrinol Metab, 2020 Mar 1. PMID 31961704
  3. Delta3,5-delta2,4-dienoyl-CoA isomerase from rat liver. Molecular characterization. Filppula SA, et al. J Biol Chem, 1998 Jan 2. PMID 9417087
  4. Isolation and characterization of rat and human cDNAs encoding a novel putative peroxisomal enoyl-CoA hydratase. FitzPatrick DR, et al. Genomics, 1995 Jun 10. PMID 7558027
  5. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. Ghosh D, et al. J Am Chem Soc, 2010 Mar 24. PMID 20178365

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
Names
Peroxisomal enoyl hydratase-like protein
enoyl CoA hydratase 1, peroxisomal
enoyl coenzyme A hydratase 1, peroxisomal
enoyl hydratase-like protein, peroxisomal
NP_072116.1
XP_063128849.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022594.1 → NP_072116.1  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_072116.1

    Status: PROVISIONAL

    Source sequence(s)
    U08976
    UniProtKB/TrEMBL
    A0A8L2QF26
    Related
    ENSRNOP00000085027.1, ENSRNOT00000096349.1
    Conserved Domains (1) summary
    cl23717
    Location:53 → 317
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    93241076..93248314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272779.1 → XP_063128849.1  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q62651
    UniProtKB/TrEMBL
    A6J9L4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62651.2 GenPept UniProtKB/Swiss-Prot:Q62651

Gene LinkOut

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