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Adcy5 adenylate cyclase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64532, updated on 4-Jan-2025

Summary

Official Symbol
Adcy5provided by RGD
Official Full Name
adenylate cyclase 5provided by RGD
Primary source
RGD:71014
See related
EnsemblRapid:ENSRNOG00000002229 AllianceGenome:RGD:71014
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and heart development. Located in endosome and sarcolemma. Biomarker of hypertension and type 2 diabetes mellitus. Orthologous to human ADCY5 (adenylate cyclase 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 212.1), Brain (RPKM 104.2) and 9 other tissues See more
Orthologs
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Genomic context

See Adcy5 in Genome Data Viewer
Location:
11q22
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (78976861..79123343, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (65471612..65618877, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (68695839..68842452, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase family A, member 5 Neighboring gene uncharacterized LOC120095660 Neighboring gene SEC22 homolog A, vesicle trafficking protein Neighboring gene uncharacterized LOC102551038 Neighboring gene uncharacterized LOC134481009 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene uncharacterized LOC134481011 Neighboring gene myosin light chain kinase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables adenylate cyclase activity  
enables adenylate cyclase activity PubMed 
enables adenylate cyclase activity  
enables adenylate cyclase activity  
enables adenylate cyclase binding  
enables adenylate cyclase binding  
enables calcium- and calmodulin-responsive adenylate cyclase activity PubMed 
enables metal ion binding  
enables scaffold protein binding  
enables scaffold protein binding  
Items 1 - 25 of 30
Process Evidence Code Pubs
involved_in G protein-coupled adenosine receptor signaling pathway  
acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating dopamine receptor signaling pathway  
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway  
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway  
acts_upstream_of_or_within adenylate cyclase-inhibiting dopamine receptor signaling pathway  
involved_in cAMP biosynthetic process PubMed 
involved_in cAMP biosynthetic process  
involved_in cAMP biosynthetic process  
involved_in cellular response to forskolin  
involved_in cellular response to forskolin  
involved_in cellular response to forskolin  
involved_in heart development PubMed 
involved_in intracellular signal transduction  
involved_in locomotory behavior  
acts_upstream_of_or_within locomotory behavior  
NOT involved_in negative regulation of neuron projection development PubMed 
involved_in neuromuscular process controlling balance  
acts_upstream_of_or_within neuromuscular process controlling balance  
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus  
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus  
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus  
Items 1 - 25 of 30
Component Evidence Code Pubs
located_in cilium  
located_in cilium  
located_in cilium  
located_in endosome PubMed 
located_in membrane  
located_in membrane  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in sarcolemma PubMed 

General protein information

Preferred Names
adenylate cyclase type 5
Names
ATP pyrophosphate-lyase 5
adenylate cyclase type V
adenylyl cyclase 5
adenylyl cyclase type V
NP_072122.2
XP_017453557.1
XP_038944541.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022600.2NP_072122.2  adenylate cyclase type 5

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    Q04400
    UniProtKB/TrEMBL
    A6IRH3
    Related
    ENSRNOP00000046488.4, ENSRNOT00000049180.4
    Conserved Domains (3) summary
    pfam00211
    Location:10631257
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:1459
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:669761
    DUF1053; Domain of Unknown Function (DUF1053)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    78976861..79123343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088613.2XP_038944541.1  adenylate cyclase type 5 isoform X1

    UniProtKB/Swiss-Prot
    Q04400
    Conserved Domains (3) summary
    pfam00211
    Location:461634
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:1459
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:669761
    DUF1053; Domain of Unknown Function (DUF1053)
  2. XM_017598068.3XP_017453557.1  adenylate cyclase type 5 isoform X2

    UniProtKB/Swiss-Prot
    Q04400
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