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Krtdap keratinocyte differentiation associated protein [ Mus musculus (house mouse) ]

Gene ID: 64661, updated on 8-May-2024

Summary

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Official Symbol
Krtdapprovided by MGI
Official Full Name
keratinocyte differentiation associated proteinprovided by MGI
Primary source
MGI:MGI:1928282
See related
Ensembl:ENSMUSG00000074199 AllianceGenome:MGI:1928282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kdap; sk221
Summary
Predicted to be involved in epidermis development. Predicted to act upstream of or within cell differentiation. Predicted to be located in lamellar body. Predicted to be active in extracellular space. Is expressed in nose and skin. Orthologous to human KRTDAP (keratinocyte differentiation associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 128.1), limb E14.5 (RPKM 47.2) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 19.24 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30487330..30490514)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30787905..30791089)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene suprabasin Neighboring gene dermokine Neighboring gene STARR-seq mESC enhancer starr_18532 Neighboring gene STARR-seq mESC enhancer starr_18534 Neighboring gene predicted gene, 32236 Neighboring gene free fatty acid receptor 2 Neighboring gene STARR-seq mESC enhancer starr_18536 Neighboring gene STARR-positive B cell enhancer ABC_E8162 Neighboring gene free fatty acid receptor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kdap, a novel gene associated with the stratification of the epithelium. Oomizu S, et al. Gene, 2000 Oct 3. PMID 11054531
  2. Identification of a conserved cluster of skin-specific genes encoding secreted proteins. Moffatt P, et al. Gene, 2004 Jun 9. PMID 15256262
  3. Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression. Bazzi H, et al. Dev Dyn, 2007 Apr. PMID 17330888
  4. Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ. Saito K, et al. iScience, 2020 Jul 24. PMID 32674056, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drmkn and Krtdap are the highest differentially expressed genes in epidermis embryonic development in mice.
    Title: Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in epidermis development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epidermis development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in lamellar body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
keratinocyte differentiation-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033131.4 → NP_001028303.1  keratinocyte differentiation-associated protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001028303.1

    Status: VALIDATED

    Source sequence(s)
    AC165340
    Consensus CDS
    CCDS21110.1
    UniProtKB/Swiss-Prot
    B7ZNU7, Q3V2T1, Q3V2T4
    Related
    ENSMUSP00000096159.2, ENSMUST00000098559.3
    Conserved Domains (1) summary
    pfam15200
    Location:24 → 102
    KRTDAP; Keratinocyte differentiation-associated

  2. NM_001364009.1 → NP_001350938.1  keratinocyte differentiation-associated protein isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC165340
    Consensus CDS
    CCDS90206.1
    UniProtKB/TrEMBL
    B7ZNU6
    Related
    ENSMUSP00000139443.2, ENSMUST00000189673.7
    Conserved Domains (1) summary
    pfam15200
    Location:24 → 76
    KRTDAP; Keratinocyte differentiation-associated

  3. NM_001364010.1 → NP_001350939.1  keratinocyte differentiation-associated protein isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    BC145437, BY703727, EH109090
    Consensus CDS
    CCDS90204.1
    Related
    ENSMUSP00000139461.2, ENSMUST00000190990.7
    Conserved Domains (1) summary
    pfam15200
    Location:24 → 90
    KRTDAP; Keratinocyte differentiation-associated

  4. NM_001364011.1 → NP_001350940.1  keratinocyte differentiation-associated protein isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    EH106855, EH109090
    Consensus CDS
    CCDS90205.1
    UniProtKB/TrEMBL
    A0A087WRR2
    Related
    ENSMUSP00000140737.2, ENSMUST00000187493.7
    Conserved Domains (1) summary
    pfam15200
    Location:24 → 88
    KRTDAP; Keratinocyte differentiation-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30487330..30490514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V2T4.1 GenPept UniProtKB/Swiss-Prot:Q3V2T4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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