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Pln phospholamban [ Rattus norvegicus (Norway rat) ]

Gene ID: 64672, updated on 4-Jan-2025

Summary

Official Symbol
Plnprovided by RGD
Official Full Name
phospholambanprovided by RGD
Primary source
RGD:619894
See related
EnsemblRapid:ENSRNOG00000079579 AllianceGenome:RGD:619894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Plm
Summary
Enables ATPase inhibitor activity and identical protein binding activity. Involved in several processes, including response to insulin; response to testosterone; and response to zinc ion. Located in sarcoplasmic reticulum and vesicle. Part of protein-containing complex. Used to study congestive heart failure; heart disease; and myocardial infarction. Biomarker of myocardial infarction and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1P and hypertrophic cardiomyopathy 18. Orthologous to human PLN (phospholamban). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 9042.3) See more
Orthologs
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Genomic context

See Pln in Genome Data Viewer
Location:
20q11
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (33166512..33182241)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (32629537..32639559)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (34633157..34642904)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member F1 Neighboring gene uncharacterized LOC120098878 Neighboring gene uncharacterized LOC134483813 Neighboring gene centrosomal protein 85-like Neighboring gene NADH:ubiquinone oxidoreductase subunit B4, pseudogene 9 Neighboring gene minichromosome maintenance 9 homologous recombination repair factor Neighboring gene anti-silencing function 1A histone chaperone Neighboring gene minichromosome maintenance 9 homologous recombination repair factor like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase inhibitor activity  
enables ATPase inhibitor activity PubMed 
enables ATPase inhibitor activity  
enables identical protein binding PubMed 
enables protein binding PubMed 
enables protein homodimerization activity  
enables protein homodimerization activity  
Items 1 - 25 of 46
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway  
involved_in acrosome assembly  
involved_in acrosome assembly  
acts_upstream_of_or_within adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  
involved_in calcium ion transport PubMed 
involved_in calcium ion transport PubMed 
acts_upstream_of_or_within cardiac muscle tissue development  
involved_in circadian sleep/wake cycle, sleep  
involved_in circadian sleep/wake cycle, sleep  
acts_upstream_of_or_within intracellular calcium ion homeostasis  
involved_in intracellular calcium ion homeostasis  
involved_in intracellular calcium ion homeostasis  
involved_in locomotor rhythm  
involved_in locomotor rhythm  
acts_upstream_of_or_within muscle cell cellular homeostasis  
involved_in negative regulation of ATP-dependent activity  
acts_upstream_of_or_within negative regulation of ATPase-coupled calcium transmembrane transporter activity  
involved_in negative regulation of ATPase-coupled calcium transmembrane transporter activity  
involved_in negative regulation of ATPase-coupled calcium transmembrane transporter activity  
involved_in negative regulation of calcium ion import into sarcoplasmic reticulum  
involved_in negative regulation of calcium ion import into sarcoplasmic reticulum  
involved_in negative regulation of calcium ion import into sarcoplasmic reticulum  
involved_in negative regulation of calcium ion transmembrane transporter activity  
involved_in negative regulation of calcium ion transport  
acts_upstream_of_or_within negative regulation of heart contraction  
involved_in negative regulation of heart rate  
involved_in negative regulation of heart rate  
involved_in regulation of ATPase-coupled calcium transmembrane transporter activity  
acts_upstream_of_or_within regulation of calcium ion import  
involved_in regulation of calcium ion transport  
involved_in regulation of calcium ion transport  
acts_upstream_of_or_within regulation of cardiac muscle cell contraction  
acts_upstream_of_or_within regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  
acts_upstream_of_or_within regulation of heart contraction  
involved_in regulation of heart contraction  
acts_upstream_of_or_within regulation of relaxation of muscle  
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  
acts_upstream_of_or_within regulation of ryanodine-sensitive calcium-release channel activity  
acts_upstream_of_or_within regulation of the force of heart contraction  
acts_upstream_of_or_within regulation of the force of heart contraction by cardiac conduction  
involved_in response to insulin PubMed 
involved_in response to testosterone PubMed 
involved_in response to zinc ion PubMed 
involved_in spermatogenesis  
involved_in visual learning  
involved_in visual learning  
Items 1 - 25 of 46
Component Evidence Code Pubs
part_of calcium ion-transporting ATPase complex  
is_active_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
is_active_in membrane  
located_in membrane  
located_in mitochondrial membrane  
part_of protein-containing complex PubMed 
is_active_in sarcoplasmic reticulum  
located_in sarcoplasmic reticulum PubMed 
located_in sarcoplasmic reticulum  
located_in sarcoplasmic reticulum membrane  
located_in sarcoplasmic reticulum membrane  
located_in vesicle PubMed 

General protein information

Preferred Names
phospholamban; cardiac phospholamban
Names
PLB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022707.2NP_073198.1  phospholamban

    See identical proteins and their annotated locations for NP_073198.1

    Status: VALIDATED

    Source sequence(s)
    CK356371, FM050525, FM055105, FM056997, FM111426
    UniProtKB/Swiss-Prot
    P61016
    UniProtKB/TrEMBL
    A6K492
    Related
    ENSRNOP00000105613.1, ENSRNOT00000122906.1
    Conserved Domains (1) summary
    TIGR01294
    Location:152
    P_lamban; phospholamban

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    33166512..33182241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099053.2XP_038954981.1  cardiac phospholamban isoform X1

    UniProtKB/Swiss-Prot
    P61016
    UniProtKB/TrEMBL
    A6K492
    Conserved Domains (1) summary
    TIGR01294
    Location:152
    P_lamban; phospholamban
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