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P2ry12 purinergic receptor P2Y12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64803, updated on 4-Jan-2025

Summary

Official Symbol
P2ry12provided by RGD
Official Full Name
purinergic receptor P2Y12provided by RGD
Primary source
RGD:621681
See related
EnsemblRapid:ENSRNOG00000013902 AllianceGenome:RGD:621681
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P2y12
Summary
Enables G protein-coupled ADP receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; monoatomic cation transmembrane transport; and positive regulation of cellular component biogenesis. Located in basal plasma membrane; caveola; and external side of plasma membrane. Used to study abdominal aortic aneurysm and thrombosis. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 42.5), Adrenal (RPKM 41.2) and 9 other tissues See more
Orthologs
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Genomic context

See P2ry12 in Genome Data Viewer
Location:
2q26
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (145631487..145673194, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (143481468..143523340, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (149440807..149482592, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y13 Neighboring gene immunoglobulin superfamily, member 10 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene arylacetamide deacetylase-like 2 like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 43
Process Evidence Code Pubs
involved_in G protein-coupled adenosine receptor signaling pathway PubMed 
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway PubMed 
involved_in G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway  
involved_in calcium ion transmembrane transport PubMed 
involved_in calcium-mediated signaling PubMed 
involved_in cell projection organization PubMed 
involved_in cellular response to ATP PubMed 
involved_in cellular response to ATP  
involved_in cellular response to ATP  
acts_upstream_of_or_within cellular response to organic cyclic compound  
involved_in cerebral cortex radial glia-guided migration PubMed 
acts_upstream_of establishment of localization in cell  
involved_in glial cell migration PubMed 
involved_in lamellipodium assembly PubMed 
acts_upstream_of monoatomic ion transport  
involved_in negative regulation of cell differentiation PubMed 
involved_in negative regulation of norepinephrine secretion PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
acts_upstream_of_or_within platelet activation  
involved_in platelet aggregation  
involved_in platelet aggregation  
involved_in positive regulation of cell adhesion mediated by integrin PubMed 
involved_in positive regulation of chemotaxis PubMed 
involved_in positive regulation of integrin activation by cell surface receptor linked signal transduction PubMed 
involved_in positive regulation of microglial cell migration PubMed 
acts_upstream_of_or_within positive regulation of monoatomic ion transport  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in positive regulation of ruffle assembly PubMed 
involved_in potassium ion transmembrane transport PubMed 
involved_in regulation of calcium ion transport PubMed 
involved_in regulation of chemotaxis PubMed 
involved_in regulation of microglial cell migration  
involved_in regulation of microglial cell migration  
involved_in response to axon injury PubMed 
involved_in substrate-dependent cell migration, cell extension  
involved_in substrate-dependent cell migration, cell extension  
involved_in visual system development  
Items 1 - 25 of 43
Component Evidence Code Pubs
located_in basal plasma membrane PubMed 
located_in caveola PubMed 
located_in cell body membrane  
located_in cell projection membrane  
located_in external side of plasma membrane PubMed 
located_in membrane  
located_in membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
P2Y purinoceptor 12
Names
P2Y12 platelet ADP receptor
purinergic receptor P2Y, G-protein coupled, 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022800.1NP_073637.1  P2Y purinoceptor 12

    See identical proteins and their annotated locations for NP_073637.1

    Status: PROVISIONAL

    Source sequence(s)
    AF313450
    UniProtKB/Swiss-Prot
    Q9EPX4
    UniProtKB/TrEMBL
    A6JVK4
    Related
    ENSRNOP00000018600.2, ENSRNOT00000018600.6
    Conserved Domains (1) summary
    pfam00001
    Location:67304
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    145631487..145673194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232407.5XP_006232469.1  P2Y purinoceptor 12 isoform X1

    See identical proteins and their annotated locations for XP_006232469.1

    UniProtKB/Swiss-Prot
    Q9EPX4
    UniProtKB/TrEMBL
    A6JVK4
    Related
    ENSRNOP00000089320.2, ENSRNOT00000097839.2
    Conserved Domains (1) summary
    pfam00001
    Location:67304
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_063282498.1XP_063138568.1  P2Y purinoceptor 12 isoform X1

    UniProtKB/Swiss-Prot
    Q9EPX4
    UniProtKB/TrEMBL
    A6JVK4
  3. XM_063282499.1XP_063138569.1  P2Y purinoceptor 12 isoform X1

    UniProtKB/Swiss-Prot
    Q9EPX4
    UniProtKB/TrEMBL
    A6JVK4
  4. XM_006232408.5XP_006232470.1  P2Y purinoceptor 12 isoform X1

    See identical proteins and their annotated locations for XP_006232470.1

    UniProtKB/Swiss-Prot
    Q9EPX4
    UniProtKB/TrEMBL
    A6JVK4
    Conserved Domains (1) summary
    pfam00001
    Location:67304
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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