P2ry12 purinergic receptor P2Y12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: P2ry12provided by RGD
Official Full Name: purinergic receptor P2Y12provided by RGD
Primary source: RGD:621681
See related: Ensembl:ENSRNOG00000013902 AllianceGenome:RGD:621681
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P2y12
Summary: Enables G protein-coupled ADP receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; inorganic cation transmembrane transport; and intracellular signal transduction. Located in basal plasma membrane; caveola; and external side of plasma membrane. Colocalizes with mitochondrion. Used to study abdominal aortic aneurysm and thrombosis. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 42.5), Adrenal (RPKM 41.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (145631487..145673194, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (143481468..143523340, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (149440807..149482592, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway.
Title: Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway.
Implication of P2Y12 receptor in uc.48+-mediated abnormal sympathoexcitatory reflex via superior cervical ganglia in myocardial ischemic rats.
Title: Implication of P2Y(12) receptor in uc.48+-mediated abnormal sympathoexcitatory reflex via superior cervical ganglia in myocardial ischemic rats.
P2Y12 inhibition in macrophages reduces ventricular arrhythmias in rats after myocardial ischemia-reperfusion.
Title: P2Y12 inhibition in macrophages reduces ventricular arrhythmias in rats after myocardial ischemia-reperfusion.
gene expression of the metabotropic purinergic receptor P2Y12 and the fractalkine receptor CX3CR1 was downregulated in the Medulla oblongata of Spontaneously Hypertensive Rats compared to Wistar kyoto rats (by 37.3% and 30.9% respectively).
Title: Microglia in the RVLM of SHR have reduced P2Y12R and CX3CR1 expression, shorter processes, and lower cell density.
that P2Y12 receptor in the stellate ganglia may participate in developing diabetic autonomic neuropathy
Title: Involvement of P2Y(12) receptor of stellate ganglion in diabetic cardiovascular autonomic neuropathy.
downregulating the P2Y12 receptor relieved mechanical and thermal hyperalgesia in gp120+ddC-treated rats.
Title: P2Y(12) receptor upregulation in satellite glial cells is involved in neuropathic pain induced by HIV glycoprotein 120 and 2',3'-dideoxycytidine.
Gene expression of the purinergic P2Y12 subtype was detected in rat retina during early postnatal days (P0 to P5), while expression levels of P2Y13 were low.
Title: P2Y(12) but not P2Y(13) Purinergic Receptor Controls Postnatal Rat Retinogenesis In Vivo.
Synergistic inhibition of both P2Y1 and P2Y12 adenosine diphosphate receptors by GLS-409 immediately attenuates platelet-mediated thrombosis and effectively blocks agonist-stimulated platelet aggregation irrespective of concomitant aspirin therapy.
Title: Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.
Establish a reliable antiplatelet profile of SAR216471, and support its potential use in clinical practice as an alternative to currently available P2Y12 receptor antagonists.
Title: SAR216471, an alternative to the use of currently available P2Y₁₂ receptor inhibitors?
Data indicate that endothelium-dependent relaxation as well as contractile vascular responses actions are not mediated by purinergic receptor P2Y G-protein coupled 12 (P2Y12) activation.
Title: Clopidogrel, independent of the vascular P2Y12 receptor, improves arterial function in small mesenteric arteries from AngII-hypertensive rats.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled ADP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled ADP receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled ADP receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled adenosine receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled purinergic nucleotide receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling using extracellular calcium source	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ATP	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ATP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ATP	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex radial glia-guided migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of norepinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within platelet activation	ISO Inferred from Sequence Orthology more info
involved_in platelet aggregation	IEA Inferred from Electronic Annotation more info
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion mediated by integrin	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of integrin activation by cell surface receptor linked signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of microglial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ruffle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microglial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of microglial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to axon injury	IDA Inferred from Direct Assay more info	PubMed
involved_in substrate-dependent cell migration, cell extension	ISO Inferred from Sequence Orthology more info
involved_in substrate-dependent cell migration, cell extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in visual system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cell body membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: P2Y purinoceptor 12

Names: P2Y12 platelet ADP receptor; purinergic receptor P2Y, G-protein coupled, 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022800.1 → NP_073637.1 P2Y purinoceptor 12

See identical proteins and their annotated locations for NP_073637.1

Status: PROVISIONAL

Source sequence(s)

AF313450

UniProtKB/Swiss-Prot

Q9EPX4

UniProtKB/TrEMBL

A6JVK4

Conserved Domains (1) summary

pfam00001
Location:67 → 304

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

145631487..145673194 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232407.5 → XP_006232469.1 P2Y purinoceptor 12 isoform X1

See identical proteins and their annotated locations for XP_006232469.1

UniProtKB/Swiss-Prot

Q9EPX4

UniProtKB/TrEMBL

A6JVK4

Related

ENSRNOP00000018600.2

Conserved Domains (1) summary

pfam00001
Location:67 → 304

7tm_1; 7 transmembrane receptor (rhodopsin family)
XM_063282498.1 → XP_063138568.1 P2Y purinoceptor 12 isoform X1

UniProtKB/Swiss-Prot

Q9EPX4

UniProtKB/TrEMBL

A6JVK4
XM_063282499.1 → XP_063138569.1 P2Y purinoceptor 12 isoform X1

UniProtKB/Swiss-Prot

Q9EPX4

UniProtKB/TrEMBL

A6JVK4
XM_006232408.5 → XP_006232470.1 P2Y purinoceptor 12 isoform X1

See identical proteins and their annotated locations for XP_006232470.1

UniProtKB/Swiss-Prot

Q9EPX4

UniProtKB/TrEMBL

A6JVK4

Conserved Domains (1) summary

pfam00001
Location:67 → 304

7tm_1; 7 transmembrane receptor (rhodopsin family)