U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

B4galnt1 beta-1,4-N-acetyl-galactosaminyl transferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64828, updated on 2-May-2024

Summary

Go to the top of the page Help
Official Symbol
B4galnt1provided by RGD
Official Full Name
beta-1,4-N-acetyl-galactosaminyl transferase 1provided by RGD
Primary source
RGD:620490
See related
Ensembl:ENSRNOG00000004839 AllianceGenome:RGD:620490
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Galgt1; GalNAc-T
Summary
Enables (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity. Involved in ganglioside biosynthetic process. Located in Golgi membrane and plasma membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 26. Orthologous to human B4GALNT1 (beta-1,4-N-acetyl-galactosaminyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 108.1), Spleen (RPKM 72.7) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64873909..64881512)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (62988429..62996190)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70439273..70459556)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene coenzyme Q4, pseudogene 1 Neighboring gene ribosomal protein S26 like 1 Neighboring gene solute carrier family 26, member 10 Neighboring gene Rho guanine nucleotide exchange factor 25 Neighboring gene uncharacterized LOC134479708 Neighboring gene deltex E3 ubiquitin ligase 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. beta 1-4N-acetylgalactosaminyltransferase can synthesize both asialoglycosphingolipid GM2 and glycosphingolipid GM2 in vitro and in vivo: isolation and characterization of a beta 1-4N-acetylgalactosaminyltransferase cDNA clone from rat ascites hepatoma cell line AH7974F. Hidari JK, et al. Biochem J, 1994 Nov 1. PMID 7980468, Free PMC Article
  2. Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver. Pohlentz G, et al. Proc Natl Acad Sci U S A, 1988 Oct. PMID 3140234, Free PMC Article
  3. Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. Takamiya K, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855236, Free PMC Article
  4. Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells. Yamashiro S, et al. J Biol Chem, 1995 Mar 17. PMID 7890749
  5. Analysis of melanoma cells stably transfected with beta 1,4GalNAc transferase (GM2/GD2 synthase) cDNA: relative glycosyltransferase levels play a dominant role in determining ganglioside expression. Ruan S, et al. Arch Biochem Biophys, 1995 Oct 20. PMID 7487055

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC93424

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
  
involved_in ganglioside biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ganglioside biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ganglioside biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ganglioside biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ganglioside biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ganglioside biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycosphingolipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosphingolipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glycosphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in limb development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within limb development ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid storage IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid storage ISO
Inferred from Sequence Orthology
more info
  
involved_in motor behavior IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within motor behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in nerve development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nerve development ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in vacuole organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vacuole organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
beta-1,4 N-acetylgalactosaminyltransferase 1
Names
(N-acetylneuraminyl)-galactosylglucosylceramide
GA2 synthase
GD2 synthase
GM2 synthase
GM2/GD2 synthase
UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide-beta-1, 4-N-acetylgalactosaminyltransferase
beta-4N-acetylgalactosaminyltransferase
NP_074051.1
XP_006241559.1
XP_038935786.2
XP_063120284.1
XP_063120285.1
XP_063120286.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022860.2 → NP_074051.1  beta-1,4 N-acetylgalactosaminyltransferase 1

    See identical proteins and their annotated locations for NP_074051.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081799
    UniProtKB/Swiss-Prot
    Q10468
    UniProtKB/TrEMBL
    A0A8L2QP76, A6HQS8
    Related
    ENSRNOP00000048586.3, ENSRNOT00000046099.4
    Conserved Domains (1) summary
    pfam00535
    Location:280 → 426
    Glycos_transf_2; Glycosyl transferase family 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    64873909..64881512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264214.1 → XP_063120284.1  beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X2

    UniProtKB/TrEMBL
    A6HQS6

  2. XM_039079858.2 → XP_038935786.2  beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q10468
    UniProtKB/TrEMBL
    A6HQS8

  3. XM_063264215.1 → XP_063120285.1  beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZLQ7

  4. XM_006241497.5 → XP_006241559.1  beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZLQ7, A0A8L2QP76
    Related
    ENSRNOP00000078917.1
    Conserved Domains (2) summary
    COG0463
    Location:299 → 397
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    pfam00535
    Location:301 → 447
    Glycos_transf_2; Glycosyl transferase family 2

  5. XM_063264216.1 → XP_063120286.1  beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q10468
    UniProtKB/TrEMBL
    A6HQS8

RNA

  1. XR_001838716.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10468.1 GenPept UniProtKB/Swiss-Prot:Q10468

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous