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Gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [ Rattus norvegicus (Norway rat) ]

Gene ID: 66020, updated on 5-Mar-2024

Summary

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Official Symbol
Gapdhsprovided by RGD
Official Full Name
glyceraldehyde-3-phosphate dehydrogenase, spermatogenicprovided by RGD
Primary source
RGD:620150
See related
Ensembl:ENSRNOG00000021009 AllianceGenome:RGD:620150
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gapds; gapdh-2
Summary
Predicted to enable glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Involved in spermatid development. Located in cytoplasm and motile cilium. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDHS (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 673.0) See more
Orthologs
human mouse all
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Genomic context

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See Gapdhs in Genome Data Viewer
Location:
1q21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95106516..95125918, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85979096..85994153, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89180063..89195347, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ATPase H+/K+ transporting subunit alpha Neighboring gene transmembrane protein 147 Neighboring gene suprabasin Neighboring gene dermokine Neighboring gene keratinocyte differentiation associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Preferential localization of rat GAPDS on the ribs of fibrous sheath of sperm flagellum and its expression during flagellar formation. Tanii I, et al. Acta Histochem Cytochem, 2007 Feb 27. PMID 17375205, Free PMC Article
  2. Fibrous sheath of mammalian spermatozoa. Eddy EM, et al. Microsc Res Tech, 2003 May 1. PMID 12672126
  3. Location and characterization of GAPDS in male reproduction. Liu J, et al. Urol Int, 2013. PMID 23306140
  4. Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis. Welch JE, et al. Mol Reprod Dev, 2006 Aug. PMID 16700075
  5. Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility. Miki K, et al. Proc Natl Acad Sci U S A, 2004 Nov 23. PMID 15546993, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycolytic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycolytic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in spermatid development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle TAS
Traceable Author Statement
more info
 PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in sperm fibrous sheath ISO
Inferred from Sequence Orthology
more info
  
located_in sperm principal piece ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Names
glyceraldehyde-3-phosphate dehydrogenase type 2
spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2
spermatogenic glyceraldehyde-3-phosphate dehydrogenase
NP_076454.1
XP_006228852.1
XP_006228853.1
XP_038946116.1
XP_063129215.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023964.1 → NP_076454.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific

    See identical proteins and their annotated locations for NP_076454.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ297631
    UniProtKB/Swiss-Prot
    Q9ESV6
    Related
    ENSRNOP00000028518.4, ENSRNOT00000028518.7
    Conserved Domains (3) summary
    COG0057
    Location:102 → 432
    GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
    pfam00044
    Location:102 → 248
    Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
    pfam02800
    Location:253 → 410
    Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    95106516..95125918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228791.5 → XP_006228853.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform X2

    Related
    ENSRNOP00000076691.1
    Conserved Domains (3) summary
    COG0057
    Location:94 → 424
    GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
    pfam00044
    Location:94 → 240
    Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
    pfam02800
    Location:245 → 402
    Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

  2. XM_006228790.5 → XP_006228852.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform X1

    See identical proteins and their annotated locations for XP_006228852.1

    UniProtKB/TrEMBL
    B1WBQ8, F7FCA4
    Related
    ENSRNOP00000059802.1
    Conserved Domains (3) summary
    COG0057
    Location:102 → 432
    GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
    pfam00044
    Location:102 → 248
    Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
    pfam02800
    Location:253 → 410
    Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

  3. XM_063273145.1 → XP_063129215.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform X3

  4. XM_039090188.2 → XP_038946116.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform X4

    Conserved Domains (1) summary
    PLN02272
    Location:1 → 287
    PLN02272; glyceraldehyde-3-phosphate dehydrogenase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESV6.1 GenPept UniProtKB/Swiss-Prot:Q9ESV6

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