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SNAP25 synaptosome associated protein 25 [ Homo sapiens (human) ]

Gene ID: 6616, updated on 4-Jan-2025

Summary

Official Symbol
SNAP25provided by HGNC
Official Full Name
synaptosome associated protein 25provided by HGNC
Primary source
HGNC:HGNC:11132
See related
Ensembl:ENSG00000132639 MIM:600322; AllianceGenome:HGNC:11132
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUP; RIC4; SEC9; SNAP; CMS18; RIC-4; SNAP-25; bA416N4.2; dJ1068F16.2
Summary
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 418.5) See more
Orthologs
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Genomic context

See SNAP25 in Genome Data Viewer
Location:
20p12.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (10218830..10307418)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (10261695..10350292)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (10199478..10288066)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene SNAP25 antisense RNA 1 Neighboring gene uncharacterized LOC105372524 Neighboring gene uncharacterized LOC124904959 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:10221152-10221653 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:10221654-10222154 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:10281144-10282061 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:10322076-10322299 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 15 Neighboring gene ribosomal protein L23a pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the pre-synaptic protein SNAP25 expression via neuronal mir-128 in primary cortical neurons PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ23079

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNAP receptor activity  
enables calcium-dependent protein binding  
enables lipid binding PubMed 
enables myosin binding  
enables protein binding PubMed 
enables protein domain specific binding  
enables syntaxin-1 binding  
enables syntaxin-1 binding PubMed 
enables transmembrane transporter binding  
enables voltage-gated potassium channel activity  
Process Evidence Code Pubs
involved_in SNARE complex assembly  
involved_in associative learning  
involved_in axonogenesis  
involved_in chemical synaptic transmission PubMed 
involved_in endosomal transport  
involved_in exocytosis  
involved_in locomotory behavior  
involved_in long-term memory  
involved_in long-term synaptic potentiation  
involved_in neurotransmitter uptake PubMed 
involved_in positive regulation of insulin secretion  
involved_in potassium ion transmembrane transport  
involved_in presynaptic dense core vesicle exocytosis  
involved_in regulation of insulin secretion PubMed 
involved_in regulation of neuron projection development  
involved_in regulation of synapse assembly  
involved_in synaptic vesicle docking PubMed 
involved_in synaptic vesicle exocytosis PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane  
involved_in synaptic vesicle priming  
Items 1 - 20 of 35
Component Evidence Code Pubs
part_of BLOC-1 complex PubMed 
part_of SNARE complex PubMed 
part_of SNARE complex  
part_of SNARE complex PubMed 
located_in actin cytoskeleton  
located_in axonal growth cone  
located_in cell cortex  
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytoskeleton PubMed 
located_in cytosol  
located_in endosome  
located_in extrinsic component of presynaptic membrane  
located_in filopodium  
located_in glutamatergic synapse  
located_in growth cone  
located_in lamellipodium  
located_in membrane  
located_in neuron projection  
located_in neuronal cell body  
located_in perinuclear region of cytoplasm  
located_in photoreceptor inner segment  
is_active_in plasma membrane  
located_in plasma membrane  
located_in presynaptic membrane PubMed 
located_in ribbon synapse  
located_in specific granule membrane  
located_in synaptic vesicle  
part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex  
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex  
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex  
located_in tertiary granule membrane  
located_in trans-Golgi network  
colocalizes_with vesicle PubMed 
part_of voltage-gated potassium channel complex  
Items 1 - 20 of 35

General protein information

Preferred Names
synaptosomal-associated protein 25
Names
resistance to inhibitors of cholinesterase 4 homolog
synaptosomal-associated protein, 25kDa
synaptosome associated protein 25kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029626.1 RefSeqGene

    Range
    5002..93590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322902.2NP_001309831.1  synaptosomal-associated protein 25 isoform SNAP25A

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13109.1
    UniProtKB/Swiss-Prot
    P60880
    Related
    ENSP00000516314.1, ENST00000706269.1
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  2. NM_001322903.2NP_001309832.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000508541.1, ENST00000691665.1
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  3. NM_001322904.2NP_001309833.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000510558.1, ENST00000693325.1
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  4. NM_001322905.2NP_001309834.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000510663.1, ENST00000689858.1
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  5. NM_001322906.2NP_001309835.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000508837.1, ENST00000685131.1
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  6. NM_001322907.2NP_001309836.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000510109.1, ENST00000691161.1
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  7. NM_001322908.2NP_001309837.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000510219.1, ENST00000687785.1
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  8. NM_001322909.2NP_001309838.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  9. NM_001322910.2NP_001309839.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  10. NM_001424415.1NP_001411344.1  synaptosomal-associated protein 25 isoform SNAP25A

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
  11. NM_001424416.1NP_001411345.1  synaptosomal-associated protein 25 isoform SNAP25B

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000509759.1, ENST00000691353.1
  12. NM_003081.5NP_003072.2  synaptosomal-associated protein 25 isoform SNAP25A

    See identical proteins and their annotated locations for NP_003072.2

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13109.1
    UniProtKB/Swiss-Prot
    P60880
    Related
    ENSP00000307341.2, ENST00000304886.6
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  13. NM_130811.4NP_570824.1  synaptosomal-associated protein 25 isoform SNAP25B

    See identical proteins and their annotated locations for NP_570824.1

    Status: REVIEWED

    Source sequence(s)
    AL023913, AL354824
    Consensus CDS
    CCDS13110.1
    UniProtKB/Swiss-Prot
    B2RAU4, D3DW16, D3DW17, P13795, P36974, P60880, P70557, P70558, Q53EM2, Q5U0B5, Q8IXK3, Q96FM2, Q9BR45
    Related
    ENSP00000254976.3, ENST00000254976.7
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    10218830..10307418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028022.2XP_016883511.1  synaptosomal-associated protein 25 isoform X2

    UniProtKB/Swiss-Prot
    P60880
    Conserved Domains (3) summary
    cd15885
    Location:143201
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15894
    Location:1082
    SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
    pfam00835
    Location:91141
    SNAP-25; SNAP-25 family
  2. XM_047440391.1XP_047296347.1  synaptosomal-associated protein 25 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    10261695..10350292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323888.1XP_054179863.1  synaptosomal-associated protein 25 isoform X2

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