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BNIP3 BCL2 interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 664, updated on 4-Jan-2025

Summary

Official Symbol
BNIP3provided by HGNC
Official Full Name
BCL2 interacting protein 3provided by HGNC
Primary source
HGNC:HGNC:1084
See related
Ensembl:ENSG00000176171 MIM:603293; AllianceGenome:HGNC:1084
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIP3; HABON
Summary
This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in liver (RPKM 54.5), fat (RPKM 52.6) and 24 other tissues See more
Orthologs
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Genomic context

See BNIP3 in Genome Data Viewer
Location:
10q26.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (131967684..131981923, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (132907935..132922186, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (133781188..133795427, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378566 Neighboring gene 60S ribosomal protein L19-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2948 Neighboring gene Sharpr-MPRA regulatory region 4393 Neighboring gene protein phosphatase 2 regulatory subunit Bdelta Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:133747865-133749064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133758459-133759288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133761987-133762488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133785771-133786641 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133794606-133795530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133809534-133810520 Neighboring gene uncharacterized LOC124902525 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133820384-133820908 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:133823019-133823543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133832958-133833629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133842692-133843192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133852590-133853427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133857569-133858086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133858087-133858604 Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133878227-133878974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:133881249-133881749 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11218 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11222 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11225 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133920928-133921428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133933330-133934168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133934169-133935006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133951279-133951800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133955152-133955999 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133956000-133956846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133959409-133959910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133959911-133960410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133960832-133961794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133977007-133977706 Neighboring gene JAKMIP3 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) in human B cells PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed
vpr Overexpression of BNIP3 is induced by HIV-1 Vpr in the transfected 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Items 1 - 25 of 47
Process Evidence Code Pubs
involved_in autophagic cell death  
involved_in autophagy of mitochondrion PubMed 
involved_in brown fat cell differentiation  
involved_in cardiac muscle cell apoptotic process  
involved_in cellular response to cobalt ion PubMed 
involved_in cellular response to hydrogen peroxide  
acts_upstream_of_or_within cellular response to hypoxia PubMed 
involved_in cellular response to hypoxia PubMed 
involved_in cellular response to mechanical stimulus  
involved_in cerebral cortex development  
involved_in defense response to virus PubMed 
involved_in granzyme-mediated programmed cell death signaling pathway PubMed 
involved_in intrinsic apoptotic signaling pathway in response to hypoxia PubMed 
involved_in mitochondrial fragmentation involved in apoptotic process PubMed 
involved_in mitochondrial outer membrane permeabilization  
involved_in mitochondrial outer membrane permeabilization PubMed 
involved_in mitochondrial protein catabolic process PubMed 
involved_in mitophagy PubMed 
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of membrane potential PubMed 
involved_in negative regulation of mitochondrial fusion PubMed 
involved_in negative regulation of mitochondrial membrane permeability involved in apoptotic process  
involved_in negative regulation of mitochondrial membrane potential  
acts_upstream_of_or_within negative regulation of programmed cell death PubMed 
involved_in negative regulation of reactive oxygen species metabolic process  
involved_in neuron apoptotic process  
involved_in oligodendrocyte differentiation  
involved_in positive regulation of apoptotic process PubMed 
involved_in positive regulation of autophagy PubMed 
involved_in positive regulation of autophagy of mitochondrion  
involved_in positive regulation of cardiac muscle cell apoptotic process  
acts_upstream_of_or_within positive regulation of macroautophagy PubMed 
involved_in positive regulation of mitochondrial calcium ion concentration  
involved_in positive regulation of mitochondrial fission PubMed 
involved_in positive regulation of programmed cell death  
involved_in positive regulation of programmed cell death PubMed 
involved_in positive regulation of protein-containing complex disassembly PubMed 
involved_in positive regulation of release of cytochrome c from mitochondria PubMed 
involved_in reactive oxygen species metabolic process PubMed 
involved_in regulation of aerobic respiration  
involved_in regulation of mitochondrial membrane permeability PubMed 
involved_in response to axon injury  
involved_in response to bacterium  
involved_in response to hyperoxia  
involved_in response to hypoxia  
involved_in response to oxygen-glucose deprivation  
involved_in reticulophagy PubMed 
Items 1 - 25 of 47
Component Evidence Code Pubs
located_in cytoplasm  
located_in dendrite  
is_active_in endoplasmic reticulum  
located_in endoplasmic reticulum PubMed 
is_active_in endoplasmic reticulum membrane PubMed 
located_in mitochondrial membrane PubMed 
located_in mitochondrial membrane PubMed 
is_active_in mitochondrial outer membrane  
is_active_in mitochondrial outer membrane PubMed 
located_in mitochondrial outer membrane PubMed 
located_in mitochondrion PubMed 
located_in mitochondrion PubMed 
located_in mitochondrion PubMed 
is_active_in nuclear envelope  
located_in nuclear envelope PubMed 
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus  
located_in postsynaptic density  

General protein information

Preferred Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Names
BCL2/adenovirus E1B 19kDa interacting protein 3
BCL2/adenovirus E1B interacting protein 3
Hypoxia-Activated BNIP3 Overlapping Non-coding RNA
nineteen kD interacting protein-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004052.4NP_004043.4  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

    Status: REVIEWED

    Source sequence(s)
    AL162274, AL732395
    Consensus CDS
    CCDS7663.3
    UniProtKB/Swiss-Prot
    O14620, Q12983, Q96GP0
    UniProtKB/TrEMBL
    Q53HF4
    Related
    ENSP00000357625.6, ENST00000368636.9
    Conserved Domains (1) summary
    pfam06553
    Location:9192
    BNIP3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    131967684..131981923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    132907935..132922186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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