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Myh15 myosin, heavy chain 15 [ Mus musculus (house mouse) ]

Gene ID: 667772, updated on 5-Mar-2024

Summary

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Official Symbol
Myh15provided by MGI
Official Full Name
myosin, heavy chain 15provided by MGI
Primary source
MGI:MGI:3643515
See related
Ensembl:ENSMUSG00000092009 AllianceGenome:MGI:3643515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG667772
Summary
Predicted to be located in cytosol and intracellular membrane-bounded organelle. Is expressed in extrinsic ocular muscle. Orthologous to human MYH15 (myosin heavy chain 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.0), frontal lobe adult (RPKM 0.2) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B5; 16 30.75 cM
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (48877763..49019926)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (49057400..49199563)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DAZ interacting protein 3, zinc finger Neighboring gene predicted gene, 22576 Neighboring gene STARR-seq mESC enhancer starr_40963 Neighboring gene STARR-seq mESC enhancer starr_40964 Neighboring gene cell proliferation regulating inhibitor of protein phosphatase 2A Neighboring gene STARR-positive B cell enhancer mm9_chr16:49164447-49164748 Neighboring gene RIKEN cDNA 1700026J12 gene Neighboring gene predicted gene 5407

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles. Rossi AC, et al. J Physiol, 2010 Jan 15. PMID 19948655, Free PMC Article
  2. Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Sambasivan R, et al. Dev Cell, 2009 Jun. PMID 19531352
  3. Diversification of stem cell molecular repertoire by alternative splicing. Pritsker M, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16183747, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166210.2 → NP_001159682.1  myosin-15

    Status: VALIDATED

    Source sequence(s)
    AC116470, AC122233, AC154447
    Consensus CDS
    CCDS49868.1
    UniProtKB/TrEMBL
    E9Q264
    Related
    ENSMUSP00000127539.2, ENSMUST00000168680.2
    Conserved Domains (5) summary
    cd14929
    Location:96 → 757
    MYSc_Myh15_mammals; class II myosin heavy chain 15, motor domain
    pfam00063
    Location:84 → 757
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:838 → 1914
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:31 → 69
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam08537
    Location:1004 → 1136
    NBP1; Fungal Nap binding protein NBP1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    48877763..49019926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249245.2 → XP_030105105.2  myosin-15 isoform X1

    Conserved Domains (2) summary
    pfam01576
    Location:709 → 1785
    Myosin_tail_1; Myosin tail
    cl22853
    Location:1 → 628
    Motor_domain; Myosin and Kinesin motor domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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