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Plin5 perilipin 5 [ Mus musculus (house mouse) ]

Gene ID: 66968, updated on 13-May-2024

Summary

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Official Symbol
Plin5provided by MGI
Official Full Name
perilipin 5provided by MGI
Primary source
MGI:MGI:1914218
See related
Ensembl:ENSMUSG00000011305 AllianceGenome:MGI:1914218
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MLDP; Lsdp5; PAT-1; 2310076L09Rik
Summary
Enables identical protein binding activity and lipase binding activity. Involved in several processes, including negative regulation of peroxisome proliferator activated receptor signaling pathway; positive regulation of sequestering of triglyceride; and regulation of lipid metabolic process. Located in cytosol and lipid droplet. Orthologous to human PLIN5 (perilipin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 44.7), adrenal adult (RPKM 29.0) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 D; 17 29.16 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56418601..56424606, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56111597..56117606, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene HDGF like 2 Neighboring gene nuclear encoded tRNA glutamic acid 4 (anticodon CTC) Neighboring gene perilipin 4 Neighboring gene leucine-rich alpha-2-glycoprotein 1 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility. Cinato M, et al. Life Sci Alliance, 2023 Apr. PMID 36717246, Free PMC Article
  2. Plin5 inhibits proliferation and migration of vascular smooth muscle cell through interacting with PGC-1α following vascular injury. Gan X, et al. Bioengineered, 2022 Apr. PMID 35470759, Free PMC Article
  3. Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway. Huo K, et al. Int Immunopharmacol, 2022 Jul. PMID 35367744
  4. Role of Plin5 Deficiency in Progression of Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice. Ma Y, et al. J Comp Pathol, 2021 Nov. PMID 34886991
  5. Isolated Plin5-deficient cardiomyocytes store less lipid droplets than normal, but without increased sensitivity to hypoxia. Li Y, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2021 Apr. PMID 33373698

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Perilipin 5 regulates hepatic stellate cell activation and high-fat diet-induced non-alcoholic fatty liver disease.
    Title: Perilipin 5 regulates hepatic stellate cell activation and high-fat diet-induced non-alcoholic fatty liver disease.
  2. Perilipin 5 protects the mitochondrial oxidative functions and improves the alcoholic liver injury in mice.
    Title: Perilipin 5 protects the mitochondrial oxidative functions and improves the alcoholic liver injury in mice.
  3. Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice.
    Title: Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice.
  4. PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport.
    Title: PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport.
  5. Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility.
    Title: Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility.
  6. Plin5 inhibits proliferation and migration of vascular smooth muscle cell through interacting with PGC-1alpha following vascular injury.
    Title: Plin5 inhibits proliferation and migration of vascular smooth muscle cell through interacting with PGC-1α following vascular injury.
  7. Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3beta-Nrf2 pathway.
    Title: Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
  8. Perilipin 5 is a novel target of nuclear receptor LRH-1 to regulate hepatic triglycerides metabolism.
    Title: Perilipin 5 is a novel target of nuclear receptor LRH-1 to regulate hepatic triglycerides metabolism.
  9. Perilipin 5 Ameliorates Hepatic Stellate Cell Activation via SMAD2/3 and SNAIL Signaling Pathways and Suppresses STAT3 Activation.
    Title: Perilipin 5 Ameliorates Hepatic Stellate Cell Activation via SMAD2/3 and SNAIL Signaling Pathways and Suppresses STAT3 Activation.
  10. Isolated Plin5-deficient cardiomyocytes store less lipid droplets than normal, but without increased sensitivity to hypoxia.
    Title: Isolated Plin5-deficient cardiomyocytes store less lipid droplets than normal, but without increased sensitivity to hypoxia.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (10)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid droplet organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid storage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of lipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of lipid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of triglyceride catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sequestering of triglyceride IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of sequestering of triglyceride IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
perilipin-5
Names
lipid droplet associated protein
lipid droplet-associated protein PAT-1
lipid storage droplet protein 5
myocardial LD protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077348.1 → NP_001070816.1  perilipin-5

    See identical proteins and their annotated locations for NP_001070816.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and encodes the same protein, compared to variant 1.
    Source sequence(s)
    AY919875, CT009719, DQ473305
    Consensus CDS
    CCDS37662.1
    UniProtKB/Swiss-Prot
    Q78IK8, Q8BVZ1
    Related
    ENSMUSP00000108695.3, ENSMUST00000113072.3
    Conserved Domains (1) summary
    pfam03036
    Location:31 → 383
    Perilipin; Perilipin family

  2. NM_025874.3 → NP_080150.2  perilipin-5

    See identical proteins and their annotated locations for NP_080150.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BY101690, DQ473305
    Consensus CDS
    CCDS37662.1
    UniProtKB/Swiss-Prot
    Q78IK8, Q8BVZ1
    Related
    ENSMUSP00000019808.6, ENSMUST00000019808.12
    Conserved Domains (1) summary
    pfam03036
    Location:31 → 383
    Perilipin; Perilipin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56418601..56424606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524805.2 → XP_006524868.1  perilipin-5 isoform X1

    Conserved Domains (1) summary
    pfam03036
    Location:33 → 381
    Perilipin; Perilipin family

  2. XM_017317614.2 → XP_017173103.1  perilipin-5 isoform X2

    Conserved Domains (1) summary
    pfam03036
    Location:3 → 255
    Perilipin; Perilipin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVZ1.1 GenPept UniProtKB/Swiss-Prot:Q8BVZ1

Gene LinkOut

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