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Cap2 cyclase associated actin cytoskeleton regulatory protein 2 [ Mus musculus (house mouse) ]

Gene ID: 67252, updated on 12-May-2024

Summary

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Official Symbol
Cap2provided by MGI
Official Full Name
cyclase associated actin cytoskeleton regulatory protein 2provided by MGI
Primary source
MGI:MGI:1914502
See related
Ensembl:ENSMUSG00000021373 AllianceGenome:MGI:1914502
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810452G09Rik
Summary
Predicted to enable actin binding activity; adenylate cyclase binding activity; and identical protein binding activity. Predicted to be involved in cAMP-mediated signaling; cell morphogenesis; and regulation of adenylate cyclase activity. Located in postsynaptic density. Is expressed in several structures, including cerebral cortex marginal layer; diaphragm; head mesenchyme; heart; and vertebral axis musculature. Used to study dilated cardiomyopathy. Orthologous to human CAP2 (cyclase associated actin cytoskeleton regulatory protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 35.6), bladder adult (RPKM 29.6) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Cap2 in Genome Data Viewer
Location:
13 A5; 13 23.83 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (46655379..46803757)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (46501903..46650281)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34408 Neighboring gene stathmin domain containing 1 Neighboring gene RNA binding motif protein 24 Neighboring gene STARR-seq mESC enhancer starr_34412 Neighboring gene predicted gene, 35110 Neighboring gene STARR-seq mESC enhancer starr_34413 Neighboring gene STARR-seq mESC enhancer starr_34414 Neighboring gene VISTA enhancer mm132 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:46712127-46712352 Neighboring gene STARR-seq mESC enhancer starr_34416 Neighboring gene family with sequence similarity 8, member A1 Neighboring gene STARR-seq mESC enhancer starr_34420 Neighboring gene nucleoporin 153 Neighboring gene STARR-positive B cell enhancer ABC_E9876 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:46831628-46831815 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:46831840-46832060 Neighboring gene predicted gene, 46412

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle. Colpan M, et al. Commun Biol, 2021 Mar 19. PMID 33742108, Free PMC Article
  2. Neuronal Actin Dynamics, Spine Density and Neuronal Dendritic Complexity Are Regulated by CAP2. Kumar A, et al. Front Cell Neurosci, 2016. PMID 27507934, Free PMC Article
  3. Deficiency of cyclase-associated protein 2 promotes arrhythmias associated with connexin43 maldistribution and fibrosis. Stöckigt F, et al. Arch Med Sci, 2016 Feb 1. PMID 26925136, Free PMC Article
  4. CAP2 in cardiac conduction, sudden cardiac death and eye development. Field J, et al. Sci Rep, 2015 Nov 30. PMID 26616005, Free PMC Article
  5. CAP2 is a regulator of the actin cytoskeleton and its absence changes infiltration of inflammatory cells and contraction of wounds. Kosmas K, et al. Eur J Cell Biol, 2015 Jan. PMID 25464902

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyclase-associated protein interacts with actin filament barbed ends to promote depolymerization and formin displacement.
    Title: Cyclase-associated protein interacts with actin filament barbed ends to promote depolymerization and formin displacement.
  2. Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts.
    Title: Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts.
  3. Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons.
    Title: Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons.
  4. CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle.
    Title: CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle.
  5. Investigated CAP adenylate cyclase-associated protein 2 (CAP2) functon in regulating the alpha-actin exchange during myofibril differentiation and skeletal muscle development.
    Title: CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function.
  6. These studies establish a direct role for CAP2 and actin dynamics in sudden cardiac death and cardiac conduction disease.
    Title: CAP2 in cardiac conduction, sudden cardiac death and eye development.
  7. Taken together, our studies reveal a role for CAP2 in wound healing which may be based on its function as a regulator of the actin cytoskeleton.
    Title: CAP2 is a regulator of the actin cytoskeleton and its absence changes infiltration of inflammatory cells and contraction of wounds.
  8. CAP2 is an essential component of the myocardial sarcomere and is essential for physiological functioning of the cardiac system, and a deficiency leads to DCM and various cardiac defects.
    Title: Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy.
  9. CAP2 is significantly expressed only in brain, heart and skeletal muscle, and skin, a C-terminal fragment of CAP2 interacts with actin, indicating that CAP2 has the capacity to bind to actin
    Title: CAP2, cyclase-associated protein 2, is a dual compartment protein.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in presynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic actin cytoskeleton organization IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in presynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenylyl cyclase-associated protein 2
Names
CAP, adenylate cyclase-associated protein, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026056.4 → NP_080332.1  adenylyl cyclase-associated protein 2

    See identical proteins and their annotated locations for NP_080332.1

    Status: VALIDATED

    Source sequence(s)
    AK013331, AK033071, AK035556, BM899250
    Consensus CDS
    CCDS26484.1
    UniProtKB/Swiss-Prot
    Q80YU7, Q9CYT6, Q9D6L0
    UniProtKB/TrEMBL
    A0A286YCS6
    Related
    ENSMUSP00000021802.9, ENSMUST00000021802.16
    Conserved Domains (2) summary
    pfam01213
    Location:5 → 296
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:322 → 474
    CAP_C; Adenylate cyclase associated (CAP) C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    46655379..46803757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516946.3 → XP_006517009.1  adenylyl cyclase-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A286YCS6
    Conserved Domains (2) summary
    pfam01213
    Location:35 → 326
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:352 → 504
    CAP_C; Adenylate cyclase associated (CAP) C terminal

  2. XM_030247379.1 → XP_030103239.1  adenylyl cyclase-associated protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q80YU7, Q9CYT6, Q9D6L0
    UniProtKB/TrEMBL
    A0A286YCS6
    Related
    ENSMUSP00000153125.2, ENSMUST00000225824.2
    Conserved Domains (2) summary
    pfam01213
    Location:5 → 296
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:322 → 474
    CAP_C; Adenylate cyclase associated (CAP) C terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CYT6.1 GenPept UniProtKB/Swiss-Prot:Q9CYT6

Gene LinkOut

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