Rab3c RAB3C, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab3cprovided by MGI
Official Full Name: RAB3C, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1914545
See related: Ensembl:ENSMUSG00000021700 AllianceGenome:MGI:1914545
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2700062I01Rik; 3110015B08Rik; 3110037E15Rik
Summary: Enables GTP-dependent protein binding activity. Acts upstream of or within regulation of exocytosis. Located in synaptic vesicle. Is expressed in several structures, including adrenal gland; alimentary system; brain; sensory organ; and skeleton. Orthologous to human RAB3C (RAB3C, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 16.0), frontal lobe adult (RPKM 15.2) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.1; 13 61.19 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (110190721..110417530, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (110054187..110280996, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab3b/3c-positive recycling vesicles are involved in and may constitute one of the recycling compartments in exogenous antigen cross-presentation.
Title: The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells.
Zwint-1 is a rab3 specific binding protein that bound preferentially to rab3c.
Title: A unique residue in rab3c determines the interaction with novel binding protein Zwint-1.
Rab3-induced modifications to primed vesicles causes a transient increase in the transduction efficacy of synaptic action potential trains and optimizes the encoding of synaptic information at an intermediate spike frequency range.
Title: Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491273

Rab3c (e-PCR), detects polymorphism
- UniSTS:498513

D13Mit130 (e-PCR), detects polymorphism
- UniSTS:141933

NoName (e-PCR)
- UniSTS:485285

AI850886 (e-PCR)
- UniSTS:164539

RH141229 (e-PCR)
- UniSTS:223225

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables myosin V binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of exocytosis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-3C

Names: small GTP-binding protein Rab3C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360099.1 → NP_001347028.1 ras-related protein Rab-3C isoform 2

Status: VALIDATED

Source sequence(s)

AC124235, AC154470, CT025643

Consensus CDS

CCDS88528.1

UniProtKB/TrEMBL

A0A286YDR2, Q3TU26

Related

ENSMUSP00000153347.2, ENSMUST00000223922.2

Conserved Domains (1) summary

cd01865
Location:28 → 192

Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
NM_023852.5 → NP_076341.1 ras-related protein Rab-3C isoform 1

See identical proteins and their annotated locations for NP_076341.1

Status: VALIDATED

Source sequence(s)

AK164316, CJ123980, CT025643

Consensus CDS

CCDS26764.1

UniProtKB/Swiss-Prot

P62823, Q62858, Q62974, Q63482, Q9CXQ1

UniProtKB/TrEMBL

Q3TU26, Q542T7

Related

ENSMUSP00000132945.2, ENSMUST00000167824.3

Conserved Domains (1) summary

cd01865
Location:30 → 194

Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

110190721..110417530 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517741.4 → XP_006517804.1 ras-related protein Rab-3C isoform X1

UniProtKB/TrEMBL

Q3TU26

Conserved Domains (1) summary

cd01865
Location:22 → 186

Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
XM_006517742.5 → XP_006517805.1 ras-related protein Rab-3C isoform X2

See identical proteins and their annotated locations for XP_006517805.1

UniProtKB/TrEMBL

Q9CXS2

Related

ENSMUSP00000153136.2, ENSMUST00000224180.2

Conserved Domains (1) summary

cl38936
Location:30 → 166

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases