Srpra signal recognition particle receptor alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srpraprovided by MGI
Official Full Name: signal recognition particle receptor alphaprovided by MGI
Primary source: MGI:MGI:1914648
See related: Ensembl:ENSMUSG00000032042 AllianceGenome:MGI:1914648
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Srpr; D11Mgi27; 1300011P19Rik
Summary: Predicted to enable GTPase activity and signal recognition particle binding activity. Predicted to be involved in protein targeting to ER. Predicted to be located in endoplasmic reticulum. Predicted to be part of signal recognition particle receptor complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in cap mesenchyme; female associated reproductive structure; male associated reproductive structure; renal interstitium; and testis. Orthologous to human SRPRA (SRP receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 54.6), placenta adult (RPKM 40.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 20.06 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (35122499..35128299)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (35211203..35217003)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:197863 (e-PCR)
- UniSTS:155977

UniSTS:236630 (e-PCR)
- UniSTS:236630

NoName (e-PCR)
- UniSTS:236631

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables signal recognition particle binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition	NAS Non-traceable Author Statement more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to ER	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
part_of signal recognition particle receptor complex	EXP Inferred from Experiment more info	PubMed
part_of signal recognition particle receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal recognition particle receptor subunit alpha

Names: DP-alpha; SR-alpha; docking protein alpha; signal recognition particle receptor ('docking protein')

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026130.1 → NP_080406.1 signal recognition particle receptor subunit alpha

Status: PROVISIONAL

Source sequence(s)

AK004967

Consensus CDS

CCDS22959.1

UniProtKB/Swiss-Prot

Q8VC45, Q921H1, Q9DBG7

Related

ENSMUSP00000034541.6, ENSMUST00000034541.12

Conserved Domains (4) summary

smart00963
Location:322 → 395

SRP54_N; SRP54-type protein, helical bundle domain

cd03115
Location:417 → 613

SRP; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The ...

TIGR00064
Location:334 → 633

ftsY; signal recognition particle-docking protein FtsY

pfam04086
Location:27 → 296

SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal