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Ergic1 endoplasmic reticulum-golgi intermediate compartment 1 [ Mus musculus (house mouse) ]

Gene ID: 67458, updated on 8-May-2024

Summary

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Official Symbol
Ergic1provided by MGI
Official Full Name
endoplasmic reticulum-golgi intermediate compartment 1provided by MGI
Primary source
MGI:MGI:1914708
See related
Ensembl:ENSMUSG00000001576 AllianceGenome:MGI:1914708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
maa-136; 1200007D18Rik
Summary
Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment and nucleoplasm. Predicted to be active in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and membrane. Predicted to be integral component of Golgi membrane and integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in neurogenic-type arthrogryposis multiplex congenita-2. Orthologous to human ERGIC1 (endoplasmic reticulum-golgi intermediate compartment 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 90.1), subcutaneous fat pad adult (RPKM 78.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ergic1 in Genome Data Viewer
Location:
17 A3.3; 17 13.34 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26779736..26875908)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26560762..26656934)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11632 Neighboring gene RIKEN cDNA 1700049J03 gene Neighboring gene predicted gene, 34606 Neighboring gene STARR-seq mESC enhancer starr_42128 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 41553 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit E Neighboring gene STARR-positive B cell enhancer ABC_E3193 Neighboring gene STARR-positive B cell enhancer ABC_E2474 Neighboring gene CREB3 regulatory factor Neighboring gene STARR-positive B cell enhancer ABC_E8660

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102406

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endoplasmic reticulum-Golgi intermediate compartment protein 1
Names
ER-Golgi intermediate compartment 32 kDa protein
ERGIC-32
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026170.3 → NP_080446.1  endoplasmic reticulum-Golgi intermediate compartment protein 1

    See identical proteins and their annotated locations for NP_080446.1

    Status: PROVISIONAL

    Source sequence(s)
    AC122252, CT025550
    Consensus CDS
    CCDS28553.1
    UniProtKB/Swiss-Prot
    Q9DC16
    UniProtKB/TrEMBL
    Q4FK22, Q69ZP5
    Related
    ENSMUSP00000132922.2, ENSMUST00000167662.8
    Conserved Domains (2) summary
    pfam07970
    Location:114 → 271
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:5 → 98
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26779736..26875908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524823.2 → XP_006524886.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X2

    UniProtKB/TrEMBL
    Q69ZP5
    Conserved Domains (2) summary
    pfam07970
    Location:119 → 286
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:22 → 113
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

  2. XM_036160753.1 → XP_036016646.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X8

    Conserved Domains (1) summary
    pfam07970
    Location:1 → 126
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

  3. XM_030250008.1 → XP_030105868.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A494BAK4, A0A494BAW5
    Related
    ENSMUSP00000158266.2, ENSMUST00000235915.2
    Conserved Domains (1) summary
    pfam07970
    Location:22 → 179
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

  4. XM_030250010.1 → XP_030105870.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X6

    UniProtKB/TrEMBL
    F6SLP4
    Related
    ENSMUSP00000127158.3, ENSMUST00000167070.3
    Conserved Domains (1) summary
    pfam07970
    Location:12 → 162
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

  5. XM_036160752.1 → XP_036016645.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A494BAK4, A0A494BAW5
    Conserved Domains (1) summary
    pfam07970
    Location:22 → 179
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

  6. XM_030250005.2 → XP_030105865.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X4

    Conserved Domains (1) summary
    pfam07970
    Location:12 → 162
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

  7. XM_036160750.1 → XP_036016643.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X1

    Conserved Domains (2) summary
    pfam07970
    Location:114 → 254
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:8 → 98
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

  8. XM_036160751.1 → XP_036016644.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X3

    UniProtKB/TrEMBL
    Q69ZP5
    Conserved Domains (2) summary
    pfam07970
    Location:114 → 271
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:8 → 98
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

  9. XM_006524824.1 → XP_006524887.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X7

    See identical proteins and their annotated locations for XP_006524887.1

    Related
    ENSMUST00000236163.2
    Conserved Domains (1) summary
    pfam07970
    Location:1 → 109
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DC16.1 GenPept UniProtKB/Swiss-Prot:Q9DC16

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