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Nsmce1 NSE1 homolog, SMC5-SMC6 complex component [ Mus musculus (house mouse) ]

Gene ID: 67711, updated on 21-May-2024

Summary

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Official Symbol
Nsmce1provided by MGI
Official Full Name
NSE1 homolog, SMC5-SMC6 complex componentprovided by MGI
Primary source
MGI:MGI:1914961
See related
Ensembl:ENSMUSG00000030750 AllianceGenome:MGI:1914961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2510027N19Rik
Summary
Predicted to enable protein dimerization activity and ubiquitin protein ligase activity. Predicted to be involved in double-strand break repair via homologous recombination; positive regulation of response to DNA damage stimulus; and postreplication repair. Predicted to act upstream of or within DNA recombination and DNA repair. Located in chromosome, centromeric region; mitotic spindle pole; and nucleus. Part of Smc5-Smc6 complex. Is expressed in pancreas epithelium. Orthologous to human NSMCE1 (NSE1 homolog, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 62.5), placenta adult (RPKM 30.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nsmce1 in Genome Data Viewer
Location:
7 F3; 7 68.87 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125066816..125090615, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (125467644..125491443, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20121 Neighboring gene predicted gene, 30717 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:132587967-132588150 Neighboring gene lysine (K)-specific demethylase 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:132615846-132616029 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:132635019-132635206 Neighboring gene STARR-positive B cell enhancer ABC_E3749 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:132700351-132700626 Neighboring gene guanosine diphosphate (GDP) dissociation inhibitor 2 pseudogene Neighboring gene interleukin 4 receptor, alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A transcriptomic analysis of Nsmce1 overexpression in mouse hippocampal neuronal cell by RNA sequencing. Gong M, et al. Funct Integr Genomics, 2020 May. PMID 31792732
  2. Nse1 and Nse4, subunits of the Smc5-Smc6 complex, are involved in Dictyostelium development upon starvation. Taniura H, et al. Dev Growth Differ, 2015 Aug. PMID 26036668
  3. Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression. Pryzhkova MV, et al. J Cell Sci, 2016 Apr 15. PMID 26919979, Free PMC Article
  4. SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Hwang G, et al. Development, 2017 May 1. PMID 28302748, Free PMC Article
  5. Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase. Gur I, et al. PLoS One, 2014. PMID 24911587, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A transcriptomic analysis of Nsmce1 overexpression in mouse hippocampal neuronal cell by RNA sequencing.
    Title: A transcriptomic analysis of Nsmce1 overexpression in mouse hippocampal neuronal cell by RNA sequencing.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Smc5-Smc6 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Smc5-Smc6 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Smc5-Smc6 complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
non-structural maintenance of chromosomes element 1 homolog
Names
non-SMC element 1 homolog
NP_001347588.2
NP_001363939.1
NP_001363940.1
NP_001363941.1
NP_001410382.1
NP_001410383.1
NP_001410384.1
NP_001410386.1
NP_001410387.1
NP_001410388.1
NP_080606.3
XP_036009279.1
XP_036009282.1
XP_036009283.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360659.2 → NP_001347588.2  non-structural maintenance of chromosomes element 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK011011, BC049558, W80039
    Conserved Domains (2) summary
    cd16493
    Location:177 → 221
    RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    pfam07574
    Location:16 → 162
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

  2. NM_001377010.1 → NP_001363939.1  non-structural maintenance of chromosomes element 1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125187
    UniProtKB/Swiss-Prot
    Q3TLN4, Q8K2B4, Q9CY20, Q9D720
    Conserved Domains (2) summary
    cd16493
    Location:190 → 234
    RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    pfam07574
    Location:16 → 175
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

  3. NM_001377011.1 → NP_001363940.1  non-structural maintenance of chromosomes element 1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125187
    UniProtKB/Swiss-Prot
    Q3TLN4, Q8K2B4, Q9CY20, Q9D720
    Conserved Domains (2) summary
    cd16493
    Location:190 → 234
    RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    pfam07574
    Location:16 → 175
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

  4. NM_001377012.2 → NP_001363941.1  non-structural maintenance of chromosomes element 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125187
    Conserved Domains (2) summary
    cd16493
    Location:177 → 221
    RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    pfam07574
    Location:16 → 162
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

  5. NM_001423453.1 → NP_001410382.1  non-structural maintenance of chromosomes element 1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125187
    UniProtKB/Swiss-Prot
    Q3TLN4, Q8K2B4, Q9CY20, Q9D720

  6. NM_001423454.1 → NP_001410383.1  non-structural maintenance of chromosomes element 1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125187
    UniProtKB/Swiss-Prot
    Q3TLN4, Q8K2B4, Q9CY20, Q9D720

  7. NM_001423455.1 → NP_001410384.1  non-structural maintenance of chromosomes element 1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125187
    UniProtKB/Swiss-Prot
    Q3TLN4, Q8K2B4, Q9CY20, Q9D720

  8. NM_001423457.1 → NP_001410386.1  non-structural maintenance of chromosomes element 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125187

  9. NM_001423458.1 → NP_001410387.1  non-structural maintenance of chromosomes element 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125187

  10. NM_001423459.1 → NP_001410388.1  non-structural maintenance of chromosomes element 1 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125187

  11. NM_026330.4 → NP_080606.3  non-structural maintenance of chromosomes element 1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK011011, BC049558
    UniProtKB/Swiss-Prot
    Q3TLN4, Q8K2B4, Q9CY20, Q9D720
    Related
    ENSMUSP00000033006.9, ENSMUST00000033006.15
    Conserved Domains (2) summary
    cd16493
    Location:190 → 234
    RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    pfam07574
    Location:16 → 175
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    125066816..125090615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153386.1 → XP_036009279.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q3TLN4, Q8K2B4, Q9CY20, Q9D720
    Conserved Domains (2) summary
    cd16493
    Location:190 → 234
    RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    pfam07574
    Location:16 → 175
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

  2. XM_036153390.1 → XP_036009283.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q3TLN4, Q8K2B4, Q9CY20, Q9D720
    Conserved Domains (2) summary
    cd16493
    Location:190 → 234
    RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    pfam07574
    Location:16 → 175
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

  3. XM_036153389.1 → XP_036009282.1  non-structural maintenance of chromosomes element 1 homolog isoform X3

    Conserved Domains (2) summary
    cd16493
    Location:94 → 138
    RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    pfam07574
    Location:1 → 79
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D720.1 GenPept UniProtKB/Swiss-Prot:Q9D720

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