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Pop1 processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 67724, updated on 30-Apr-2024

Summary

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Official Symbol
Pop1provided by MGI
Official Full Name
processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1914974
See related
Ensembl:ENSMUSG00000022325 AllianceGenome:MGI:1914974
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932434G09Rik
Summary
Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic; tRNA 5'-leader removal; and tRNA catabolic process. Predicted to be located in nucleolus. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Human ortholog(s) of this gene implicated in anauxetic dysplasia 2. Orthologous to human POP1 (POP1 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.5), limb E14.5 (RPKM 3.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Pop1 in Genome Data Viewer
Location:
15 B3.1; 15 14.34 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34495457..34530799)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34495311..34530653)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene glutamate rich 5 Neighboring gene reactive intermediate imine deaminase A homolog Neighboring gene STARR-seq mESC enhancer starr_38330 Neighboring gene predicted gene, 22208 Neighboring gene NIPA-like domain containing 2 Neighboring gene RIKEN cDNA 4930413F20 gene Neighboring gene predicted gene, 53873

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. POP1 inhibits MSU-induced inflammasome activation and ameliorates gout. de Almeida L, et al. Front Immunol, 2022. PMID 36225929, Free PMC Article
  2. The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease. de Almeida L, et al. Immunity, 2015 Aug 18. PMID 26275995, Free PMC Article
  3. Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes. Xiao S, et al. Annu Rev Biochem, 2002. PMID 12045094, Free PMC Article
  4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. POP1 inhibits MSU-induced inflammasome activation and ameliorates gout.
    Title: POP1 inhibits MSU-induced inflammasome activation and ameliorates gout.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36536

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ribonuclease P RNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ribonuclease P activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in tRNA 5'-leader removal ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA decay ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of multimeric ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
  
part_of nucleolar ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleolar ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease MRP complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribonucleases P/MRP protein subunit POP1
Names
processing of precursors 1
ribonucleases P/MRP protein subunit homolog
NP_080616.1
NP_690854.1
XP_006520221.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026340.3 → NP_080616.1  ribonucleases P/MRP protein subunit POP1 isoform 2

    See identical proteins and their annotated locations for NP_080616.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK016547, BM204185, CN722321
    Consensus CDS
    CCDS27419.1
    UniProtKB/TrEMBL
    Q9D4G5
    Related
    ENSMUSP00000078037.6, ENSMUST00000079028.6
    Conserved Domains (2) summary
    pfam06978
    Location:107 → 257
    POP1; Ribonucleases P/MRP protein subunit POP1
    pfam08170
    Location:618 → 707
    POPLD; POPLD (NUC188) domain

  2. NM_152894.2 → NP_690854.1  ribonucleases P/MRP protein subunit POP1 isoform 1

    See identical proteins and their annotated locations for NP_690854.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC126028, AK016547, BM204185, CN722321
    Consensus CDS
    CCDS27420.1
    UniProtKB/TrEMBL
    Q8K205
    Related
    ENSMUSP00000052654.8, ENSMUST00000052290.14
    Conserved Domains (2) summary
    pfam06978
    Location:107 → 257
    POP1; Ribonucleases P/MRP protein subunit POP1
    pfam08170
    Location:648 → 737
    POPLD; POPLD (NUC188) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    34495457..34530799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520158.5 → XP_006520221.1  ribonucleases P/MRP protein subunit POP1 isoform X1

    Conserved Domains (1) summary
    pfam08170
    Location:110 → 201
    POPLD; POPLD (NUC188) domain
Nucleotide Protein Strain
Heading Accession and Version

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