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Zfp639 zinc finger protein 639 [ Mus musculus (house mouse) ]

Gene ID: 67778, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp639provided by MGI
Official Full Name
zinc finger protein 639provided by MGI
Primary source
MGI:MGI:1915028
See related
Ensembl:ENSMUSG00000027667 AllianceGenome:MGI:1915028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZASC1; Znf639; ANC-2H01; 6230400O18Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein self-association. Predicted to be involved in several processes, including negative regulation by host of viral transcription; positive regulation by host of viral transcription; and regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Is expressed in several structures, including brain; early conceptus; genitourinary system; and retina nuclear layer. Orthologous to human ZNF639 (zinc finger protein 639). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 7.7), CNS E14 (RPKM 7.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp639 in Genome Data Viewer
Location:
3 A3; 3 15.75 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (32564355..32574982)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (32510264..32520833)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7906 Neighboring gene predicted gene, 54172 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E6047 Neighboring gene STARR-seq mESC enhancer starr_07337 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6048 Neighboring gene STARR-seq mESC enhancer starr_07340 Neighboring gene STARR-positive B cell enhancer ABC_E2662 Neighboring gene mitofusin 1 Neighboring gene STARR-seq mESC enhancer starr_07342 Neighboring gene guanine nucleotide binding protein (G protein), beta 4 Neighboring gene STARR-seq mESC enhancer starr_07343 Neighboring gene STARR-seq mESC enhancer starr_07344 Neighboring gene STARR-seq mESC enhancer starr_07347 Neighboring gene STARR-seq mESC enhancer starr_07348 Neighboring gene STARR-positive B cell enhancer ABC_E179 Neighboring gene actin-like 6A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZASC1 knockout mice exhibit an early bone marrow-specific defect in murine leukemia virus replication. Seidel S, et al. Virol J, 2013 Apr 24. PMID 23617998, Free PMC Article
  2. Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. Bogaerts S, et al. Exp Cell Res, 2005 Nov 15. PMID 16182284
  3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in symbiont entry into host cell ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 639
Names
zinc finger protein ZASC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161818.1 → NP_001155290.1  zinc finger protein 639 isoform 1

    See identical proteins and their annotated locations for NP_001155290.1

    Status: VALIDATED

    Source sequence(s)
    AK078000, CO042682
    Consensus CDS
    CCDS17295.1
    UniProtKB/Swiss-Prot
    A9X400, Q8BWU9, Q99KZ6
    Related
    ENSMUSP00000141341.2, ENSMUST00000193287.6
    Conserved Domains (2) summary
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:408 → 481
    zf-C2H2_8; C2H2-type zinc ribbon

  2. NM_001356625.2 → NP_001343554.1  zinc finger protein 639 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC130281
    Consensus CDS
    CCDS17295.1
    UniProtKB/Swiss-Prot
    A9X400, Q8BWU9, Q99KZ6
    Conserved Domains (2) summary
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:408 → 481
    zf-C2H2_8; C2H2-type zinc ribbon

  3. NM_001429053.1 → NP_001415982.1  zinc finger protein 639 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC130281

  4. NM_001429054.1 → NP_001415983.1  zinc finger protein 639 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC130281

  5. NM_001429055.1 → NP_001415984.1  zinc finger protein 639 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130281

  6. NM_001429056.1 → NP_001415985.1  zinc finger protein 639 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130281

  7. NM_001429057.1 → NP_001415986.1  zinc finger protein 639 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130281

  8. NM_144519.5 → NP_653102.1  zinc finger protein 639 isoform 1

    See identical proteins and their annotated locations for NP_653102.1

    Status: VALIDATED

    Source sequence(s)
    AC130281
    Consensus CDS
    CCDS17295.1
    UniProtKB/Swiss-Prot
    A9X400, Q8BWU9, Q99KZ6
    Related
    ENSMUSP00000141446.2, ENSMUST00000191783.6
    Conserved Domains (2) summary
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:408 → 481
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    32564355..32574982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163252.1 → XP_036019145.1  zinc finger protein 639 isoform X2

    UniProtKB/TrEMBL
    Q80UZ3
    Conserved Domains (2) summary
    sd00017
    Location:361 → 381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:364 → 437
    zf-C2H2_8; C2H2-type zinc ribbon

  2. XM_030252772.1 → XP_030108632.1  zinc finger protein 639 isoform X2

    UniProtKB/TrEMBL
    Q80UZ3
    Conserved Domains (2) summary
    sd00017
    Location:361 → 381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:364 → 437
    zf-C2H2_8; C2H2-type zinc ribbon

  3. XM_006535527.5 → XP_006535590.1  zinc finger protein 639 isoform X1

    See identical proteins and their annotated locations for XP_006535590.1

    UniProtKB/Swiss-Prot
    A9X400, Q8BWU9, Q99KZ6
    Conserved Domains (2) summary
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:408 → 481
    zf-C2H2_8; C2H2-type zinc ribbon

  4. XM_006535529.5 → XP_006535592.1  zinc finger protein 639 isoform X1

    UniProtKB/Swiss-Prot
    A9X400, Q8BWU9, Q99KZ6
    Related
    ENSMUSP00000029203.8, ENSMUST00000029203.13
    Conserved Domains (2) summary
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:408 → 481
    zf-C2H2_8; C2H2-type zinc ribbon

  5. XM_030252771.2 → XP_030108631.1  zinc finger protein 639 isoform X2

    UniProtKB/TrEMBL
    Q80UZ3
    Conserved Domains (2) summary
    sd00017
    Location:361 → 381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:364 → 437
    zf-C2H2_8; C2H2-type zinc ribbon

  6. XM_036163250.1 → XP_036019143.1  zinc finger protein 639 isoform X1

    UniProtKB/Swiss-Prot
    A9X400, Q8BWU9, Q99KZ6
    Conserved Domains (2) summary
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:408 → 481
    zf-C2H2_8; C2H2-type zinc ribbon

  7. XM_006535530.5 → XP_006535593.1  zinc finger protein 639 isoform X2

    See identical proteins and their annotated locations for XP_006535593.1

    UniProtKB/TrEMBL
    Q80UZ3
    Conserved Domains (2) summary
    sd00017
    Location:361 → 381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:364 → 437
    zf-C2H2_8; C2H2-type zinc ribbon
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KZ6.1 GenPept UniProtKB/Swiss-Prot:Q99KZ6

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